The prevalence of endocrinopathic laminitis among horses presented for laminitis at a first-opinion/referral equine hospital

Karikoski, Ninja; Horn, Isabella; McGowan, T. W.; McGowan, Cathy

doi:10.1016/j.domaniend.2011.05.004

Cited by 136 publications

(122 citation statements)

References 28 publications

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“…1 Laminitis has typically been considered to develop secondary to systemic inflammation or gastrointestinal tract disease [2][3][4] or uneven weight distribution in limbs. 5 More recently, results of other studies 6,7 have indicated that endocrine disturbances (ie, endocrinopathic laminitis) account for most cases of laminitis evaluated at firstopinion practices in Europe and the United States. 6,7 Such endocrinopathies include pituitary pars intermedia dysfunction and hyperinsulinemia attributable to equine metabolic syndrome.…”

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confidence: 99%

“…5 More recently, results of other studies 6,7 have indicated that endocrine disturbances (ie, endocrinopathic laminitis) account for most cases of laminitis evaluated at firstopinion practices in Europe and the United States. 6,7 Such endocrinopathies include pituitary pars intermedia dysfunction and hyperinsulinemia attributable to equine metabolic syndrome. Recently, laminitis has been induced in horses and ponies with a pEHC technique.…”

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confidence: 99%

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Morphological and cellular changes in secondary epidermal laminae of horses with insulin-induced laminitis

Karikoski¹,

Patterson-Kane²,

Asplin³

et al. 2014

ajvr

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Results indicated SEL elongation, narrowing, and alteration in orientation developed in all feet of ponies with insulin-induced laminitis. This was primarily attributable to cell stretching that developed at the same time as an accelerated cell death-proliferation cycle; differences in cell cycle responses among laminar regions between forefeet and hind feet may have been attributable to differences in load bearing.

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confidence: 99%

mentioning

confidence: 99%

Morphological and cellular changes in secondary epidermal laminae of horses with insulin-induced laminitis

Karikoski¹,

Patterson-Kane²,

Asplin³

et al. 2014

ajvr

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“…Since laminitis associated with hormonal changes usually occurs in the chronic phase (Donaldson et al, 2004), it is assumed that its development phase in naturally occurring cases leads to a subtle and progressive remodeling of the laminar tissue of the hoof, which can manifest clinically in the chronic phase of laminitis (Johnson et al, 2004). This assumption is supported by the studies of Polzer and Slater (1996), who observed a high incidence of chronic laminitis in older horses, which can be associated with the development of PPID (Karikoski et al, 2011). In the studies of associations between laminitis and age no significant associations were found between acute and chronic phase and no increase in hoof disease was observed in older horses (Wylie et al, 2011).…”

Section: Discussionmentioning

confidence: 98%

“…Donaldson et al (2004) showed that 7% of horses suffering from laminitis treated at a clinic in the United States (USA) were diagnosed with PPID. Karikoski et al (2011) observed that 89% of 36 horses presented for laminitis at an equine hospital showed endocrine disorders, and one third of the animals were diagnosed with pituitary pars intermedia dysfunction. The early association of laminitis to a primary cause enables the treatment of the underlying disease, thereby obtaining better results for laminitis.…”

Section: Discussionmentioning

confidence: 99%

Histopathological hoof laminar changes in horses with Pituitary Pars Intermedia Adenoma: cases report

Laskoski

Dittrich

Valadão

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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Laminitis in horses is often associated with endocrine disorders, especially the pituitary pars intermedia dysfunction (PPID) in older animals. Morphologic exams of the laminar tissue of the hoof were performed in two horses with suspected PPID, with no clinical signs of laminitis. Changes compatible with laminitis of endocrine origin were observed, such as rounding of the nuclei of the basal cells, thinning and stretching of the secondary epidermal laminae and tissue proliferation. PPID horses with no clinical signs of laminitis may be affected by lesions of the laminar tissue of the hoof that compromise the integrity of the dermal-epidermal junction and may develop clinical symptoms of the disease. It has been suggested that the development stage of endocrine laminitis is longer, but further studies should be conducted to confirm it.Keywords: laminitis, metabolic syndrome, Cushing's syndrome, endocrine disorders, pituitary adenoma RESUMO A laminite em cavalos está frequentemente associada a distúrbios endócrinos, como a disfunção da pars intermedia da pituitária (PPID) em animais mais velhos. Exames morfológicos do tecido laminar do

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“…Em estudo realizado por Karikoski et al (2011), pouco mais de 89% dos cavalos apresentando laminite como sinal primário a desenvolveram em consequência de enfermidades metabólicas.…”

Section: Resistência à Insulinaunclassified

<b>Avaliação da frutosamina em cavalos com e sem resistência à insulina</b>

Fernandes¹

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AGRADECIMENTOSA minha namorada Leticia Signori de Castro pelo companheirismo, "auxilio" no processamento das análises estatísticas e paciência que foram determinantes no cumprimento desta empreitada.A minha amada mestra e orientadora professora Dr. Carla Bargi Belli pela paciência, dedicação e eficiência na contenção de surtos do seu orientado.Aos funcionários do hospital veterinário Rosendo José Pires Neto, Gervásio Garcia da Silva, Felipe dos Santos Belau, José Antônio Lopes, Cícero Antônio da Silva e Marcos Roberto Rodrigues Alves, pelas piadas ruins, café das 7h e café das "aproximadamente" 14h que tornaram os dois últimos anos muito mais alegres.

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The prevalence of endocrinopathic laminitis among horses presented for laminitis at a first-opinion/referral equine hospital

Cited by 136 publications

References 28 publications

Morphological and cellular changes in secondary epidermal laminae of horses with insulin-induced laminitis

Morphological and cellular changes in secondary epidermal laminae of horses with insulin-induced laminitis

Histopathological hoof laminar changes in horses with Pituitary Pars Intermedia Adenoma: cases report

<b>Avaliação da frutosamina em cavalos com e sem resistência à insulina</b>

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