The prevalence of diabetes mellitus in population of hypertensive patients according to ESSE RF study results

Zhernakova, Yu V; Валерьевна, Жернакова Юлия; Чазова, И Е; Евгеньевна, Чазова Ирина; Ощепкова, Е. В.; Владимировна, Ощепкова Елена; Шальнова, С. А.; Анатольевна, Шальнова Светлана; Konradi, Alexandra; Олеговна, Конради Александра; Rotar, O.; Петровна, Ротарь Оксана; Yarovaya, Elena; Борисовна, Яровая Елена; Shlyahto, E.V.; Владимирович, Шляхто Евгений; Бойцов, С. А.; Анатольевич, Бойцов Сергей

doi:10.26442/2075-082x_15.1.56-62

Cited by 14 publications

(8 citation statements)

References 8 publications

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“…8 The ESSE-RF study (10 regions of the Russian Federation, 2012-2014) estimated the prevalence of diabetes mellitus based on self-report and fasting glucose: 9.4% of men and 7.4% of women aged 45-54 years old and 13.6% of men and 16.5% of women aged 55-64 years old had diabetes mellitus. 9 Similarly to our study, other studies conducted in Russia report that a high proportion of diabetes is undiagnosed: 54% in NATION study, 8 43% in HAPIEE, 10 and 27% in UEMS. 11 Differences between these estimates and estimates from our study can be explained by the different age structures of the studied populations, different access to healthcare services in Russian regions, and different methods for diabetes prevalence estimates.…”

Section: Discussionsupporting

confidence: 89%

“…5 Data on type 2 diabetes prevalence in Russia have been reported in a few population-based studies based either on glycated hemoglobin [6][7][8] or fasting glucose. [9][10][11] These studies report relatively high prevalence of type 2 diabetes in Russia ranging from 7% to 16%, with the highest burden being in women compared with men at older ages.…”

Section: Introductionmentioning

confidence: 99%

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What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity

Iakunchykova

Averina

Wilsgaard

et al. 2021

BMJ Open Diab Res Care

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IntroductionCompared with many other countries Russia has a high prevalence of diabetes in men and women. However, contrary to what is found in most other populations, the risk is greater among women than men. The reasons for this are unclear.Research design and methodsPrevalence and risk factors for diabetes at ages 40–69 years were compared in two population-based studies: Know Your Heart (KYH) (Russia, 2015–2018, n=4121) and the seventh wave of the Tromsø Study (Tromsø 7) (Norway, 2015–2016, n=17 649). Diabetes was defined by the level of glycated hemoglobin and/or self-reported diabetes and/or diabetes medication use. Marginal structural models were used to estimate the role of key risk factors for diabetes in differences between the studies.ResultsAge-standardized prevalence of diabetes was higher in KYH compared with Tromsø 7 in men (11.6% vs 6.2%) and in women (13.2% vs 4.3%). Age-adjusted ORs for diabetes in KYH compared with Tromsø 7 were 2.01 (95% CI 1.68 to 2.40) for men and 3.66 (95% CI 3.13 to 4.26) for women. Adiposity (body mass index and waist circumference) explained none of this effect for men but explained 46.0% (39.6, 53.8) for women. Addition of smoking and C reactive protein, as further mediators, slightly increased the percentage explained of the difference between studies to 55.5% (46.5, 66.0) for women but only to 9.9% (−0.6, 20.8) for men.ConclusionsAdiposity is a key modifiable risk factor that appears to explain half of the almost threefold higher female prevalence of diabetes in Russia compared with Norway, but none of the twofold male difference.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity

Iakunchykova

Averina

Wilsgaard

et al. 2021

BMJ Open Diab Res Care

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“…Распространенность АО в РФ составила 55%, тогда как доля лиц с ожирением, определяемым по индексу массы тела, была значительно ниже (33,4%). Была выявлена обратная связь между АО и курением (р<0,0001) [26].…”

Section: взаимосвязь нарушений дыхания во сне с ссрunclassified

“…Специалистами НМИЦ кардиологии впервые проведен анализ коагулогических ФР ССЗ (фибриногена, D-димера и глобального показателя, характеризующего антикоагулянтную функцию системы протеина С -ТромбоПас) в популяции взрослого населения г. Томска и их взаимосвязи с основными демографическими и клиническими характеристиками [26]. Показано, что наличие хотя бы одного из маркеров гиперкоагуляции, к которым относили уровень фибриногена >3,7 г/л, D-димера -500 нг/мл, а индекс ингибирования образования тромбина в тесте ТромбоПас (PICI%) ≤84%, выявлено у 55,4% обследованных.…”

Section: распространенность протромботических состояний с использованием традиционных и новых маркеров (тромбопас)unclassified

Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study. Ten years later

Бойцов

Драпкина²,

Шляхто

et al. 2021

Cardiovasc Ther Prev

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The growing weight of noncommunicable diseases, primarily cardiovascular diseases (CVDs), is a great threat to the health of population worldwide, worsening the quality of life and reducing life expectancy. Realization of this threat led to initiation of epidemiological study by the Russian Ministry of Health to investigate the prevalence of CVDs and their risk factors, since it is CVDs that specify the high allcause mortality in Russia. In the modern history of epidemiology of non-infectious disease, the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study occupies a special place. This is the largest epidemiological study, which is considered as a continuation of preventive activity in order to obtain unbiased information on epidemiological characteristics of population in Russian regions. To conduct the study, the Research Organizing Committee of ESSE-RF study was created and a protocol was developed. All interested scientists and experts from following three centers took part in the work: National Medical Research Center for Therapy and Preventive Medicine, Almazov National Medical Research Center, National Medical Research Center of Cardiology. The Russian regions were justified and selected for participation. In 2012-2014 ESSE-RF study, 13 following Russian regions took part: Volgograd, Vologda, Voronezh, Ivanovo, Kemerovo, Tyumen Oblasts; Krasnoyarsk and Primorsky Krai; the Republic of North Ossetia (Alania); cities of Orenburg, Samara, St. Petersburg and Tomsk. All participated regions used a single study protocol, while biochemical parameters were determined in Federal centers using the same equipment and reagent kits. The paper presents some of the most interesting results that indicate a change in Russian epidemiological situation over the past few years. After the end of cross-sectional study, a field of priority research areas was formed in each center.Conclusion. Epidemiological studies are the most important scientific tool for assessing the prevalence of diseases, their risk factors, as well as predicting adverse events. Based on the results obtained, healthcare system and medical community determine priorities and develop related strategies (population-based and high-risk strategies). For their implementation, a regulatory and legal framework is being created.

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“…Так, курение встречалось у 25,7% [4], повышенное артериальное давление (АД)у 43,5% обследованных лиц. Среди пациентов с АГ более чем у 70% выявлен повышенный уровень холестерина (ХС) ЛПНП, у 8,6% -СД [5].…”

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Gender-age peculiarities of smoking and diabetes mellitus role in the development of myocardial infarction in patients with arterial hypertension

et al. 2021

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Arterial hypertension (AH), smoking and type 2 diabetes mellitus (T2DM) are the risk factors for the development of myocardial infarction (MI). Their age and gender peculiarities of AH have been studied only in a small number of epidemiological studies. Aim. To study the effect of smoking status and type 2 diabetes on the incidence of MI in men and women with hypertension. Materials and methods. The frequency of MI in men and women with hypertension confirmed by ECG criteria was analyzed depending on age, smoking status and type 2 diabetes. 28 899 hypertensive patients of primary health care in 20102016 were included in the registry of hypertension. Results. In the age of 2544 the number of visits of men and women with hypertension in primary health care was the same, thereafter the ratio of men progressively had been decreasing with the age. The incidence of MI in men with hypertension is significantly higher at all ages than in women (it is 18.3 times higher at the age of 2544). 37.4% of men and 94.8% of women with hypertension have never smoked. The maximum incidence of MI is in middle-aged men (33.0%) and in old-aged women (14.1%) groups, who stopped smoking. MI developed in 3.7 times more often in hypertensive young-age men group who are smoking than in nonsmokers, in those who stopped smoking 13 times more often. The maxima of the curves of the incidence of MI in women with hypertension, based on the smoking status, shifted towards an older age in comparison with men. Percutaneous coronary intervention / Coronary artery bypass graft surgery was performed 2 times more often in hypertensive patients with MI who stopped smoking, compared to nonsmokers. The incidence of MI in hypertensive patients with diabetes in middle-aged men increased by 1.6 times, in women 2.5 times. The higher influence of diabetes mellitus on escalation of MI incidence in women with hypertension than in men persisted until old age. The incidence of MI was 9.8% in never-smoked, 17.7% for smokers and 28.3% for stopped smoking hypertensive patients with diabetes. In the group of patients who never smoked, the risk of MI increased by 1.8 times in the men group and 2.8 in women with AH and DM. However, the odds of MI development in nonsmoking men and women groups with hypertension and diabetes did not significant. Conclusion. Gender-age characteristics of the influence of smoking and type 2 diabetes on the risk of MI in patients with hypertension in primary health care were disclosed. Such risk factors for MI as male gender and smoking are most significant at a young age. In old age, smoking status no longer affects the risk of MI, while the male gender remains important at all ages. The higher incidence of MI in men with hypertension (18.3 times at a young age) compared to women is explained by both the influence of gender and the higher frequency of smoking (12 times). T2DM increases the risk of developing MI in middle age and older. In hypertensive patients with type 2 diabetes, the incidence of MI is maximally increased in middle age in women by 2.5 times; in men 1.6 times. Smoking in patients with AH and type 2 diabetes leads to an additional increase of MI risk (up to 2.8 times).

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The prevalence of diabetes mellitus in population of hypertensive patients according to ESSE RF study results

Cited by 14 publications

References 8 publications

What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity

What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity

Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study. Ten years later

Gender-age peculiarities of smoking and diabetes mellitus role in the development of myocardial infarction in patients with arterial hypertension

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