The prevalence of depression in adult onset idiopathic dystonia: Systematic review and metaanalysis

Escobar, Alex Medina; Pringsheim, Tamara; Goodarzi, Zahra; Martino, Davide

doi:10.1016/j.neubiorev.2021.02.036

Cited by 19 publications

(17 citation statements)

References 84 publications

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“…To our knowledge, this is the first systematic review to provide an overview of the evidence regarding potential cognitive functions that are affected, or not, in pwCD. Psychological difficulties such as anxiety and depression are highly prevalent in CD (and have recently been reviewed elsewhere, see Girach et al, 2019;Medina Escobar et al, 2021). Given the known impact of psychological difficulties on cognition (Strauss et al, 2006;Zuckerman et al, 2018), the interaction between distress and cognitive outcomes where reported, will also be briefly discussed.…”

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confidence: 99%

A Systematic Review of Cognition in Cervical Dystonia

et al. 2023

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Growing evidence points to a spectrum of non-motor symptoms, including cognitive difficulties that have a greater impact on functional outcomes and quality of life than motor symptoms in cervical dystonia (CD). Some cognitive impairments have been reported; however, findings are inconsistent, and described across mixed groups of dystonia. The current review aimed to examine the evidence for cognitive impairments in CD. MEDLINE, EMBASE, PsychINFO and Web of Science databases were searched. Studies were included if they met the following criteria (i) cross-sectional or longitudinal studies of adults with CD, (ii) where the results of standardised measures of cognitive or neuropsychological function in any form were assessed and reported, (iii) results compared to a control group or normative data, and (iv) were published in English. Results are presented in a narrative synthesis. Twenty studies were included. Subtle difficulties with general intellectual functioning, processing speed, verbal memory, visual memory, visuospatial function, executive function, and social cognition were identified while language, and attention and working memory appear to be relatively spared. Several methodological limitations were identified that should be considered when interpreting the evidence to describe a specific profile of cognitive impairment in CD. Clinical and research implications are discussed.

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confidence: 99%

A Systematic Review of Cognition in Cervical Dystonia

et al. 2023

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“…Unlike previous reports, our models included depression as a relevant predictor of the presence of spread. Depression is a well‐established non‐motor feature in adult‐onset isolated dystonia, as confirmed by large service‐based [41] and population‐based [29] investigations, as well as by study meta‐analyses [42]. Given the uncertainty around the relative timing of depression onset and spread in the Dystonia Coalition cohort, its effect as a predictor of spread could be explained by reverse causality, that is, patients with spread are more likely to develop depression.…”

Section: Discussionmentioning

confidence: 95%

Predictive modeling of spread in adult‐onset isolated dystonia: Key properties and effect of tremor inclusion

Wang

Sajobi

Morgante

et al. 2021

Euro J of Neurology

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Background and purpose Several clinical and demographic factors relate to anatomic spread of adult‐onset isolated dystonia, but a predictive model is still lacking. The aims of this study were: (i) to develop and validate a predictive model of anatomic spread of adult‐onset isolated dystonia; and (ii) to evaluate whether presence of tremor associated with dystonia influences model predictions of spread. Methods Adult‐onset isolated dystonia participants with focal onset from the Dystonia Coalition Natural History Project database were included. We developed two prediction models, one with dystonia as sole disease manifestation (“dystonia‐only”) and one accepting dystonia OR tremor in any body part as disease manifestations (“dystonia OR tremor”). Demographic and clinical predictors were selected based on previous evidence, clinical plausibility of association with spread, or both. We used logistic regressions and evaluated model discrimination and calibration. Internal validation was carried out based on bootstrapping. Results Both predictive models showed an area under the curve of 0.65 (95% confidence intervals 0.62–0.70 and 0.62–0.69, respectively) and good calibration after internal validation. In both models, onset of dystonia in body regions other than the neck, older age, depression and history of neck trauma were predictors of spread. Conclusions This predictive modeling of spread in adult‐onset isolated dystonia based on accessible predictors (demographic and clinical) can be easily implemented to inform individuals’ risk of spread. Because tremor did not influence prediction of spread, our results support the argument that tremor is a part of the dystonia syndrome, and not an independent or coincidental disorder.

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“…Depression is common in patients with CD. A recent meta-analysis has yielded depression prevalence of 31.5% in patients with CD ( 30 ). In the current study, anxiety/depression was reported by 68.2% of the patients with CD, indicating that the rate of psychiatric comorbidities in CD might be underestimated.…”

Section: Discussionmentioning

confidence: 99%

Health-Related Quality of Life in Cervical Dystonia Using EQ-5D-5L: A Large Cross-Sectional Study in China

et al. 2022

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PurposeThe study aimed to evaluate the health-related quality of life (HRQoL) measured by the five-level EuroQol-5 dimensions (EQ-5D-5L) in patients with cervical dystonia, and to explore the determinants of HRQoL in patients with cervical dystonia.MethodsEQ-5D-5L health state profiles were converted into a single aggregated “health utility” score. A calibrated visual analog scale (EQ VAS) was used for self-rating of current health status. Multiple linear regression analysis was used to explore the factors associated with HRQoL in cervical dystonia.ResultsA total of 333 patients with cervical dystonia were enrolled in the analysis, with an average age of 44.3 years old. The most common impaired dimension of health was anxiety/depression (73.6%), followed by pain/discomfort (68.2%) and usual activities (48%). The median health utility score was 0.80, and the median EQ VAS score was 70.2. Multivariate linear regression analysis indicated that disease duration and the scores of the Hamilton Depression Rating Scale (HDRS), Pittsburgh sleep quality index (PSQI), Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) Part I, and TWSTRS Part III were associated with the health utility scores. After adjusting other parameters, the TWSTRS Part III score and the HDRS score were significantly associated with the EQ VAS scores (p < 0.05).ConclusionThis study evaluated HRQoL in patients with cervical dystonia using the Chinese version of the EQ-5D-5L scale. We found that, besides motor symptoms, non-motor symptoms, including depression, pain, and sleep quality, could be greater determinants of HRQoL in patients with cervical dystonia. Management of non-motor symptoms, therefore, may help improve HRQoL in patients with cervical dystonia.

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The prevalence of depression in adult onset idiopathic dystonia: Systematic review and metaanalysis

Cited by 19 publications

References 84 publications

A Systematic Review of Cognition in Cervical Dystonia

A Systematic Review of Cognition in Cervical Dystonia

Predictive modeling of spread in adult‐onset isolated dystonia: Key properties and effect of tremor inclusion

Health-Related Quality of Life in Cervical Dystonia Using EQ-5D-5L: A Large Cross-Sectional Study in China

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