The prevalence of congenital fetal anomalies for the past 5 years (2013-2017)

Nagorneva, Stanislava V.; Владимировна, Нагорнева Станислава; Prokhorova, Victoria S.; Сергеевна, Прохорова Виктория; Shelaeva, Elizaveta V.; Валерьевна, Шелаева Елизавета; Khudovecova, Alexandra M.; Михайловна, Худовекова Александра

doi:10.17816/jowd67344-48

Cited by 10 publications

(4 citation statements)

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“…Congenital malformations today occupy a leading place among genetic pathologies, reaching 2.7 % in some European countries (https://eu-rd-platform.jrc.ec.europa. eu/eurocat/eurocat-data/prevalence_en), in Russiafrom 1.9 to 7 % (Baranov, Vakharlovskiĭ and Aĭlamazian, 1994;Nagorneva, Prokhorova, Shelaeva, and Khudovecova, 2018). To reduce the risk of reproductive loss, various genetic technologies are used at all stages of human reproduction.…”

Section: Genetics In the System Of Human Reproductionmentioning

confidence: 99%

Prospects for biobanking in reproductive health: genetic aspects

Glotov

Nasykhova²,

Dvoynova³

et al. 2022

BioComm

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Currently, one of the most promising areas of medicine is the development and implementation of new biomedical technologies in the field of human reproduction with the involvement of resources of biobanks and biocollections as well as modern genetic technologies. In this review, we considered the key dimensions of personalized medicine, such as biobanking and genomic medicine. We illustrated crucial aspects in the organization of human bioresource collections and the difficulties arising in the interaction of specialists in the field of biobanking. Problems in obtaining informed consent and collecting personal data are described. Furthermore, the need for creating and developing complex information systems for storing, processing, and analyzing data, creating genetic databases is emphasized. Foreign experience in consolidation of biobank data and the results of genomic studies is summarized. We also describe D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology’s experience in creating collections of human biomaterials (today it contains more than 60,000 samples, including samples of blood and its derivatives (plasma, serum, whole blood), urine samples, placental tissue, cell cultures, DNA, RNA, and others) and in quality management. The main results of genetic research are provided. Experience in these studies served as the basis for the creation of Biobank “Genofond” and the unique scientific facility “Human Reproductive Health”. The principle of creation of the collection, its purpose, and objectives for future research in the genetics of reproduction are described.

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Section: Genetics In the System Of Human Reproductionmentioning

confidence: 99%

Prospects for biobanking in reproductive health: genetic aspects

Glotov

Nasykhova²,

Dvoynova³

et al. 2022

BioComm

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“…Высокий уровень рождения детей с врожденными пороками сердца (ВПС) и существенный вклад этой патологии в формирование перинатальной, младенческой и детской смертности, а также уровень инвалидизации детей, в том числе после радикального хирургического лечения [1,2], определяют значимость поиска методов прогнозирования и профилактики риска формирования ВПС на этапе планирования беременности.…”

Section: Introductionunclassified

“…Необходимо отметить, что более 80% ВПС не имеют семейной истории, ведущего генетического дефекта и не являются синдромом хро-мосомного заболевания [2]. Эти спорадические несиндромальные ВПС являются по своим этиологии и патогенезу мультифакториальными заболеваниями.…”

Section: Introductionunclassified

Features of blocking HLA-DR and HLA-G BY the human IgG fraction from the plasma of multiparous women

Шабалдин

Deeva

Сухих

et al. 2020

Fundamentalʹnaâ i kliničeskaâ medicina

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Aim. To obtain a purified IgG preparation from the plasma of multiparous women and to evaluate its functional activity towards HLA-DR and HLA-G molecules.Materials and Methods. IgG preparation was prepared by means of affinity chromatography using the DEAE Affi-Gel Blue system. The purity of the isolated preparation was assessed by immunoelectrophoresis. Functional activity of the IgG preparation against HLA-DR and HLA-G molecules was assessed in peripheral blood lymphocytes isolated from 14 apparently healthy men of reproductive age by flow cytometry.Results. A 30 mL IgG fraction was obtained with a protein concentration of 4.3 g/l and a residual albumin less than 0.1 g/l. The protein concentration in the obtained fraction corresponded to the lower limit of IgG concentration in human serum. Immunoelectrophoresis showed that the IgG was the only antibody fraction in the chromatographic washout. Purified IgG fraction suppressed the expression of HLA-DR and HLA-G in donor lymphocytes.Conclusion. The purified IgG fraction from multiparous women can have a significant preventive and therapeutic effect against immune disorders in the mother-embryo system and therefore might halt the development of congenital heart defects by blocking HLA-DR and HLA-G in the lymphocytes.

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“…Врожденные пороки развития являются всемирной проблемой, вызывая перинатальную и младенческую смертность [5,10]. Среди новорожденных частота врожденных пороков, выявляемых в течение первого года жизни, значительно варьирует в разных странах и в среднем составляет 4-6%, а вклад данной патологии в структуру младенческой смертности может достигать 35-40% [10].…”

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The Prevalence of Congenital Malformations and Anomalies of the Chest Organs and Systems among Adult Population of the Kabardino-Balkarian Republic

Samorodov

Соколович

Сабанчиева

et al. 2022

Tuberk. bolezni lëgk.

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The objective: to assess the prevalence and structure of congenital malformations and anomalies of the chest organs and systems among adult population of the Kabardino-Balkarian Republic.Subjects. 1,729 patients with suspected respiratory tuberculosis examined from 2016 to 2021 inclusive in Differential Diagnostic Department of TB Dispensary by the Ministry of Health of the Kabardino-Balkarian Republic.Results. In 89 (5.1%) patients, congenital anomalies and malformations of the chest organs and systems were detected, 42/89 (47.2%) had one more concurrent respiratory pathology; oncological diseases (42.9%) and respiratory tuberculosis (23.8%) prevailed. In patients with malformations of the musculoskeletal system of the chest organs, tuberculosis was more often detected, oncological diseases were equally frequent in patients with malformations of the musculoskeletal system and mediastinum.

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The prevalence of congenital fetal anomalies for the past 5 years (2013-2017)

Cited by 10 publications

References 0 publications

Prospects for biobanking in reproductive health: genetic aspects

Prospects for biobanking in reproductive health: genetic aspects

Features of blocking HLA-DR and HLA-G BY the human IgG fraction from the plasma of multiparous women

The Prevalence of Congenital Malformations and Anomalies of the Chest Organs and Systems among Adult Population of the Kabardino-Balkarian Republic

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