The Prevalence of Coal Workers’ Pneumoconiosis in US Coal Miners

Morgan, William J.; Burgess, Dean B.; Jacobson, George; O'Brien, R.; Pendergrass, Eugene P.; Reger, R. B.; Shoub, E P

doi:10.1080/00039896.1973.10666356

Cited by 64 publications

(56 citation statements)

References 5 publications

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“…Included in coal mine dust are polynuclear aromatics and aerosol particulate (2). Exposure to coal mine dust is measured in this study through years of underground mining, a useful measure of coal mine dust exposure (8). Miners having less than 25 years underground have been defined as having low coal mine dust ex--posure and miners with 25 years or more underground have been defined as having high coal mine dust exposure.…”

Section: Methodsmentioning

confidence: 99%

Lung cancer, stomach cancer, and smoking status among coal miners. A preliminary test of a hypothesis.

Ames¹,

Gamble²

1983

Scand J Work Environ Health

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Section: Methodsmentioning

confidence: 99%

Lung cancer, stomach cancer, and smoking status among coal miners. A preliminary test of a hypothesis.

Ames¹,

Gamble²

1983

Scand J Work Environ Health

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“…Levels of LMW iron in A549 cells correlated with the levels of bioavailable iron in the coals. Interestingly, prevalence of pneumoconiosis also paralleled with the levels of LMW iron in the A549 cells (Morgan et al 1973).…”

Section: Determination Of Lmw Iron In Sera Of Healthy Individuals At mentioning

confidence: 79%

Bio-Available Iron in Breast Cancer of Older Women

Huang¹,

Akhmedkhanov²,

Zeleniuch-Jaquotte³

et al. 2002

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“…For example, in the U.S., the disease is more common in Pennsylvania than in the rest of Appalachia. It occurs less frequently in the Mid-West and much less so in the West (52). In France, coal miners of Provence did not display CWP (0%) whereas the prevalence of CWP in coal miners of Nord Pas de Calais was 24% (53).…”

Section: Other Risk Predictors Of Cwpmentioning

confidence: 99%

Iron, Oxidative Stress, and Cell Signaling in the Pathogeneses of Coal Workers' Pneumoconiosis, Silicosis, and Asbestosis

Huang¹

2011

Am. J. Biomed. Sci.

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Coal workers' pneumoconiosis (CWP), silicosis, and asbestosis were the most common occupational diseases in the 20 th Century. The passage of the Mine Health and Safety Act in 1968 resulted in reduction of occupational exposures to coal, silica, and asbestos fibers and, thus, decreased incidence of the diseases. However, the most recent data showed that, from the beginning of the 21 st Century, a significant increase in the occurrence and severity of CWP took place in the U.S. This occurrence necessitates a comprehensive review of this issue. Among many factors, cumulative dust exposure (CDE), a product of dust concentration and working tenure, is the most important cause of the disease. The molecular mechanisms mostly center on iron-mediated oxidative stress and cell signaling, leading to inflammation, possibly epithelial mesenchymal transition (EMT) to fibroblasts, and ultimately fibrotic changes. In order to combat the recent increase in CWP, reducing coal dust levels and decreasing the toxicity of the coal at the work setting are the first practical measures to take. Exposure biomarkers, which are based on iron, and early disease biomarkers in inflammation and EMT can be developed for early detection before the conventional chest x-ray diagnosis is possible. In summary, through dust reduction, delay of mining highly toxic coal, and identification of susceptible workers, CWP is preventable.

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The Prevalence of Coal Workers’ Pneumoconiosis in US Coal Miners

Cited by 64 publications

References 5 publications

Lung cancer, stomach cancer, and smoking status among coal miners. A preliminary test of a hypothesis.

Lung cancer, stomach cancer, and smoking status among coal miners. A preliminary test of a hypothesis.

Bio-Available Iron in Breast Cancer of Older Women

Iron, Oxidative Stress, and Cell Signaling in the Pathogeneses of Coal Workers' Pneumoconiosis, Silicosis, and Asbestosis

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