The prevalence of Brucella spp. in dairy products in the Middle East region: A systematic review and meta-analysis

Abedi, Abdol‐Samad; Hashempour‐Baltork, Fataneh; Alizadeh, Adel Mirza; Beikzadeh, Samira; Hosseini, Hedayat; Bashiry, Moin; Taslikh, Musarreza; Javanmardi, Fardin; Sheidaee, Zhaleh; Sarlak, Zahra; Mofid, Vahid; Fakhri, Yadolah; Khaneghah, Amin Mousavi

doi:10.1016/j.actatropica.2019.105241

Cited by 40 publications

(15 citation statements)

References 44 publications

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“…Bovine brucellosis is highly contagious and is transmitted via direct contact with infected animals or indirectly via contaminated fomites. Humans usually get infection via contact with abortive (and birth) fluids, mucous membranes (e.g., mouth, eyes) and consumption of contaminated raw milk or milk products from infected animals [9,10]. This disease is characterized by abortion in the last trimester followed by retention of fetal membranes in animals.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and Associated Risk Factors of Bovine Brucellosis in District Gujranwala, Punjab, Pakistan

Khan

Rehman

Khalid

et al. 2021

Animals

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Bovine brucellosis is a contagious zoonotic disease that causes economic losses through abortion and infertility. A cross-sectional study was designed to determine the seroprevalence and associated risk factors of bovine brucellosis in district Gujranwala of Punjab, Pakistan. A total of 220 bovine sera (112 from buffaloes, 108 from cattle) from 46 unvaccinated herds were collected. Parallel testing by the Rose Bengal Plate Test (RBPT) and Indirect Enzyme-linked Immunosorbent Assay (I-ELISA) showed a 58.7% (27/46) herd-level and 22.7% (50/220) animal-level seroprevalence. Seroprevalence was higher (p < 0.001, OR = 7.62) in adult animals (37.2%) compared to younger animals (4.9%). A herd size of >10 animals (p = 0.021, OR = 7.83), less housing space (p = 0.037, OR = 6.39) and history of abortion at the farm (p = 0.023, OR = 5.6) were found as risk factors associated with the seropositivity of brucellosis. There was a substantial agreement between the RBPT and I-ELISA results (Cohen’s kappa coefficient (κ) = 64.16, percent agreement = 89.5%). In conclusion, a relatively higher seroprevalence was found compared to the previous reports from the country. Standardization and validation of the advanced diagnostic tests would be needed. Biosecurity, personal protection, quarantine measures and routine screening of animals at the farm level and disease awareness programs and consumption of pasteurized milk in the human population will be helpful in preventing the transmission/zoonosis of the disease.

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Section: Introductionmentioning

confidence: 99%

Seroprevalence and Associated Risk Factors of Bovine Brucellosis in District Gujranwala, Punjab, Pakistan

Khan

Rehman

Khalid

et al. 2021

Animals

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“…Even if Coxiella Burnetii and Bartonella represent the most common cause of fastidious germ related Blood culture negative endocarditis (BNCE) [ 14 ], brucella should be considered in the differential diagnosis of this entity, especially in a young patient with prosthetic valve and living in endemic area such as middle east where the prevalence of brucella in dairy product is 29 % [ 15 ]; because earlier diagnosis and treatment lead to decreasing morbidity and mortality related to this infection.…”

Section: Discussionmentioning

confidence: 99%

Brucella prosthetic valve endocarditis with septic and cardiogenic shock

Hamieh

2020

IDCases

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A young man with aortic prosthetic valve replacement, presented with prolonged fever and diagnosed with brucella endocarditis based on positive transthoracic echo findings with high titer positive brucellacapt serology. He was started on medical treatment with doxycycline and rifampin to which gentamicin and ceftriaxone were added and he was planned for surgical intervention. Unfortunately, the patient developed cardiogenic with septic shock before performing surgery and died within 24 h soon after admission.

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“…Kuwait shares extensive, however, loose borders with neighboring Iraq and Saudi Arabia. Both countries are endemic for brucellosis and control of sheep brucellosis in Iraq and Saudi Arabia is very challenging due to the nomadic animal production system of those countries [ 5 , 7 , 16 ]. Illegal transboundary transportation of diseased animals is unlikely to occur because of effective border control.…”

Section: Discussionmentioning

confidence: 99%

“…Brucella melitensis is also the member of the genus Brucella with the highest zoonotic risk, and most human cases are caused by B. melitensis worldwide. Although many developing countries in the Middle East have implemented highly restrictive control programs, the disease is still endemic, resulting in significant public health problems in most of the Middle Eastern countries [ 5 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Sheep Brucellosis in Kuwait: A Large-Scale Serosurvey, Identification of Brucella Species and Zoonotic Significance

Al-Sherida

El-Gohary

Mohamed

et al. 2020

Veterinary Sciences

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Brucellosis is a common zoonotic disease of major concern in humans of Kuwait, and B. melitensis causes most human cases. The disease is endemic in small ruminants, cattle, and camels for decades, causing substantial economic losses in livestock production. However, a nationwide large-scale investigation of brucellosis in the small ruminant population has not been done in the past two decades. A serosurvey of sheep brucellosis in the five districts of Kuwait with most animal production farms was done between 2016 and 2019. In total, 67,054 serum samples from 233 sheep herds were collected and tested. Additionally, milk and tissue samples were collected from 46 seropositive cases for bacteriology. Thirty persons from seven seropositive farms were tested by serology. The incidence of seropositive cases was 7% in districts devoid of vaccination, while it was 4.7% in farms with history of vaccination. The serosurvey revealed that 89% of non-vaccinated herds (n = 181) were seropositive by Rose Bengal test (RBT), buffered acidified plate antigen test (BAPAT), and complement fixation test (CFT). Prevalence of 100% was reported for non-vaccinated sheep herds from Al-Wafrah and Al-Jahra districts, followed by those from Al-Salmi (88.24%), Al-Abdali (86.7%) and Kabd (75.6%). Implementation of vaccination with B. melitensis Rev.1 vaccine and test-and-slaughters in 20 herds reduced the seroprevalence to 33.3% and 25% in herds from Al-Jahra and AL-Wafrah, respectively. B. melitensis was isolated from 20 samples (43.5%). More than half of the examined animal owners (56.6%) tested positive for Brucella using RBT, BAPAT and CFT. The high numbers of infected herds and high prevalence in herdsmen are alarming. Thus, control measures have to be ensured immediately. The epidemiological situation in Kuwait is similar to those of the neighboring countries and the combined action of these states is needed. The understanding of the economic and public health impact of brucellosis in Kuwait needs to grow.

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The prevalence of Brucella spp. in dairy products in the Middle East region: A systematic review and meta-analysis

Cited by 40 publications

References 44 publications

Seroprevalence and Associated Risk Factors of Bovine Brucellosis in District Gujranwala, Punjab, Pakistan

Seroprevalence and Associated Risk Factors of Bovine Brucellosis in District Gujranwala, Punjab, Pakistan

Brucella prosthetic valve endocarditis with septic and cardiogenic shock

Sheep Brucellosis in Kuwait: A Large-Scale Serosurvey, Identification of Brucella Species and Zoonotic Significance

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