The prevalence of autoantibodies among right and left handed schizophrenic patients and control subjects

Chengappa, K. N. Roy; Ganguli, Rohan; Ulrich, Richard F.; Rabin, Bruce S.; Cochran, Joyce C.; Brar, Jaspreet S.; Yang, Zhenlin; DeLeo, M.

doi:10.1016/0006-3223(92)90083-c

Cited by 11 publications

(8 citation statements)

References 23 publications

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“…Studies characterizing systemic antibodies detected in patients with schizophrenia are listed in Table 1. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] An abundance of evidence regarding schizophrenia comes from studies that examined antinuclear antibodies. Eight investigations found higher concentrations of antinuclear antibodies in patients with schizophrenia than in controls; however, the populations in these studies varied.…”

Section: Systemic Antibody Studiesmentioning

confidence: 99%

“…Eight investigations found higher concentrations of antinuclear antibodies in patients with schizophrenia than in controls; however, the populations in these studies varied. [17][18][19][20][21][22][23][24] For example, one large study involved 225 patients (125 men, 100 women) with schizophrenia or schizoaffective disorder and 327 controls (141 men, 186 women) who had no psychiatric or autoimmune disorders and did not abuse drugs or alcohol at the time of the study. 20 The researchers examined the prevalence of a panel of systemic autoantibodies in study patients and controls.…”

Section: Systemic Antibody Studiesmentioning

confidence: 99%

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The Case for Autoimmunity in the Etiology of Schizophrenia

Goldsmith

Rogers

2008

Pharmacotherapy

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The treatment of schizophrenia has frustrated clinicians for over 50 years. Despite advances in neurotransmitter identification and the development of drugs targeting these transmitters, total remission of the disease is not always achieved. Potential etiologies other than neurotransmitter dysfunction merit consideration. One intriguing concept is the possible contribution of autoimmunity in patients with the disease. This breakdown of self-tolerance has been implicated in patients with other chronic diseases, such as type 1 diabetes mellitus and myasthenia gravis. The literature on autoimmunity as a possible mechanism in the pathogenesis of schizophrenia can be conflicting, but there is a substantial amount of circumstantial, although not conclusive, evidence of immune dysfunction in patients with schizophrenia.

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Section: Systemic Antibody Studiesmentioning

confidence: 99%

Section: Systemic Antibody Studiesmentioning

confidence: 99%

The Case for Autoimmunity in the Etiology of Schizophrenia

Goldsmith

Rogers

2008

Pharmacotherapy

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“…On the biological level, both conditions share presence of immune cells in the target organs (Nikkila et al, 2001), association with a particular MHC haplotypes (Shi et al, 2009;Wright et al, 1996a), deposition of antigen-antibody complexes in the affected organ (Rudin, 1980), cytokine system dysfunction (Chang et al, 2011;Zhang et al, 2002), improvement of the disease symptoms with immunosuppression (Shi et al, 2009;Valbonesi and Garelli, 1983) and high serum levels of autoantibodies (AAb) (Chengappa et al, 1992;Heath and Krupp, 1967;Hornig et al, 1999;Laske et al, 2008;Padmos et al, 2004;Schulz et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

Spectrum of Autoantibodies in Tunisian Psychiatric Inpatients

Sidhom

Laadhar

Zitouni

et al. 2012

Immunological Investigations

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One hundred and three psychiatric inpatients (74 men) were assessed for a wide spectrum of autoantibodies including antinuclear, antismooth muscle, antimitochondrial, antiDNA, anti-phospholipid, anti-cardiolipin IgG and IgM, antikeratin, rheumatoid factor, antithyroperoxydase, antigliadin IgA and IgG, antitransgutaminase, and antiendomysium antibodies. Four groups of patients were considered separately, including 47 with schizophrenia, 23 with schizoaffective disorder, 16 with bipolar disorder and 17 patients with other different psychiatric diagnosis. Forty one healthy, age- and sex-matched blood donors were used as a control group. There were no significant difference in the prevalence of the different autoantibodies between patients (N = 103) and controls except for antigliadin IgG (30.1 vs 9.8 respectively, p = 0.01). Presence of autoantibodies was influenced by age but not by sex or treatment. As for diagnosis categories, patients with bipolar disorder presented significantly more autoantibodies than the three other categories and controls. These results point out a possible autoimmune activation in at least a subgroup of psychiatric patients especially amongst those suffering from bipolar disorder.

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“…Some small immunological studies have supported this theory by finding different T cell subsets,19 cytokines,20 and autoantibodies21 between left and right handers. However, the aetiological processes involved in IBD and other immune mediated diseases reported in association with left handedness are poorly understood and the model has received much criticism 8…”

Section: Discussionmentioning

confidence: 93%