Inflammatory bowel disease and laterality: is left handedness a risk?

Morris, Danielle; Montgomery, Scott; Galloway, M.; Pounder, R. E.; Wakefield, Andrew J.

doi:10.1136/gut.49.2.199

Cited by 17 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The association between left-handedness and increased risk of inflammatory bowel diseases (Crohn's disease and ulcerative colitis) has been confirmed in probably the largest study of the problem (a sample of 17,197 subjects living in Great Britain), carried out by Morris et al [52].…”

Section: Handedness-related Differencesmentioning

confidence: 83%

Brain asymmetry, immunity, handedness

et al. 2011

View full text Add to dashboard Cite

AbstractThe principle of symmetry-asymmetry is widely presented in the structural and functional organization of the nonliving and living nature. One of the most complex manifestations of this principle is the left-right asymmetry of the human brain. The present review summarizes previous and contemporary literary data regarding the role of brain asymmetry in neuroimmunomodulation. Some handedness-related peculiarities are outlined additionally. Brain asymmetry is considered to be imprinted in the formation and regulation of the individual’s responses and relationships at an immunological level with the external and internal environment. The assumptions that the hemispheres modulate immune response in an asymmetric manner have been confirmed in experiments on animals. Some authors assume that the right hemisphere plays an indirect role in neuroimmunomodulation, controlling and suppressing the left hemispheric inductive signals.

show abstract

Section: Handedness-related Differencesmentioning

confidence: 83%

Brain asymmetry, immunity, handedness

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Indeed, a signifi cant negative association has been observed between left -handedness and early satiation (Fujiwara et al 2011) and a positive one with infl ammatory bowel diseases (Morris et al 2001), in which Ang II is also involved (Fandriks 2011). …”

Section: Th E Gut In the Neuroendocrine Integration For The Cardiovasmentioning

confidence: 99%

Bidirectional asymmetry in the neurovisceral communication for the cardiovascular control: New insights

Prieto

Segarra

Martı́nez-Cañamero

et al. 2017

Endocrine Regulations

View full text Add to dashboard Cite

Th e cardiovascular control involves a bidirectional functional connection between the brain and heart. We hypothesize that this connection could be extended to other organs using endocrine and autonomic nervous systems (ANS) as communication pathways. Th is implies a neuroendocrine interaction controlling particularly the cardiovascular function where the enzymatic cascade of the renin-angiotensin system (RAS) plays an essential role. It acts not only through its classic endocrine connection but also the ANS. In addition, the brain is functionally, anatomically, and neurochemically asymmetric. Moreover, this asymmetry goes even beyond the brain and it includes both sides of the peripheral nervous and neuroendocrine systems. We revised the available information and analyze the asymmetrical neuroendocrine bidirectional interaction for the cardiovascular control. Negative and positive correlations involving the RAS have been observed between brain, heart, kidney, gut, and plasma in physiologic and pathologic conditions. Th e central role of the peptides and enzymes of the RAS within this neurovisceral communication, as well as the importance of the asymmetrical distribution of the various RAS components in the pathologies involving this connection, are particularly discussed. In conclusion, there are numerous evidences supporting the existence of a neurovisceral connection with multiorgan involvement that controls, among others, the cardiovascular function. Th is connection is asymmetrically organized.

show abstract

“…Further studies into the clinical and biological features of AAU associated with HLA-B27 or axial spondyloarthritis could include studying handedness as a factor in laterality as originally proposed by Geschwind and Behan 16 17. Sex hormones, like testosterone and oestrogen, and proteins whose expression is influenced by sex hormones, could affect the immune system and could also influence the manifestations of and susceptibility to AAU, altering the recurrence rates.…”

Section: Discussionmentioning

confidence: 99%