The Prevalence of Aspirin Hypersensitivity in Patients with Nasal Polyposis and Contributing Factors

Bavbek, Sevim; Dursun, Berna; Dursun, Engin; Korkmaz, Hakan; Karasoy, Durdu

doi:10.2500/ajra.2011.25.3660

Cited by 19 publications

(16 citation statements)

References 37 publications

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“…Respiratory symptoms are less likely to be associated with other types of NSAID hypersensitivity. Our study confirmed that NSAID‐induced respiratory reactions are more prevalent among patients with asthma and/or chronic rhinosinusitis suggesting that NERD type of hypersensitivity could be most likely diagnosed in these patients. Although respiratory symptoms of NSAID hypersensitivity are usually considered to be a component of the ‘aspirin triad’, in our study only 15% of the patients complaining of breathing difficulties after NSAIDs had coexisting asthma and rhinosinusitis and more than half have not reported neither upper nor lower respiratory tract disorders.…”

Section: Discussionsupporting

confidence: 79%

“…Most studies published earlier assessed the prevalence of aspirin/NSAID‐induced respiratory symptoms in selected populations of asthmatics and/or patients with chronic rhinosinusitis (CRS), which is compatible with the diagnosis of type I hypersensitivity (NERD), previously called ‘aspirin triad’ . The prevalence of respiratory type of hypersensitivity to NSAIDs depended on the population sampled was higher among patients with asthma , patients with rhinosinusitis and nasal polyposis and seemed to be more prevalent among more severe asthmatics . Only few studies analyzed the prevalence of NSAID‐induced hypersensitivity in the general population, and these recruited patients only in single countries .…”

mentioning

confidence: 99%

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Respiratory hypersensitivity reactions to NSAIDs in Europe: the global allergy and asthma network (GA²LEN) survey

Makowska

Burney

Jarvis

et al. 2016

Allergy

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Section: Discussionsupporting

confidence: 79%

mentioning

confidence: 99%

Respiratory hypersensitivity reactions to NSAIDs in Europe: the global allergy and asthma network (GA²LEN) survey

Makowska

Burney

Jarvis

et al. 2016

Allergy

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“…This is in contrast to other definitions where AERD was used to refer to patients with asthma and intolerance to COX-1 inhibitors but not necessarily chronic sinus disease or nasal polyps, 13, 15, 32–35 or to patients who had nasal polyps and COX-1 inhibitor intolerances but not necessarily asthma 36 . Given the lack of universally accepted terminology and definitions, it is common for the same diagnosis ( i.e.…”

Section: Discussionmentioning

confidence: 93%

Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease

Stevens

Peters

Hirsch

et al. 2017

The Journal of Allergy and Clinical Immunology: In Practice

191

184

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Background Aspirin exacerbated respiratory disease (AERD) comprises the triad of chronic rhinosinusitis with nasal polyps (CRSwNP), asthma, and intolerance to inhibitors of the cyclooxygenase-1 (COX-1) enzyme. The prevalence of AERD remains unclear and few studies have compared the clinical characteristics of patients with AERD to those with CRSwNP alone, asthma alone, or both CRSwNP and asthma. Objective To determine the prevalence of AERD within a tertiary care setting, and to identify unique clinical features that could distinguish these patients from those with CRSwNP+Asthma or CRSwNP. Methods Electronic medical records of patients at Northwestern in Chicago, Illinois were searched by computer algorithm and then manual chart review to identify 459 patients with CRSwNP alone, 412 with CRSwNP+Asthma, 171 with AERD, and 300 with asthma only. Demographic and clinical features including sex, atopy, and sinus disease severity were characterized. Results The prevalence of AERD among CRSwNP patients was 16%. AERD patients had undergone two-fold more sinus surgeries (p<0.001) and were significantly younger at the time of their first surgery (40±13 years) than CRSwNP patients (43±14 years, p<0.05). Atopy was significantly more prevalent in patients with AERD (84%) or asthma (85%) than in CRSwNP (66%, p<0.05). More patients with AERD (13%) had corticosteroid-dependent disease than CRSwNP+Asthma (4%, p<0.01) or asthma (1%, p<0.001). Conclusions AERD is common among CRSwNP patients; even though AERD patients have CRSwNP and asthma, the clinical course of their disease is not the same as of patients who have CRSwNP and asthma but are tolerant to COX-1 inhibitors.

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“…ECRS has significantly higher association with asthma and higher incidence of aspirin sensitivity 13,14 . In our study, bronchial asthma and aspirin sensitivity were found to be more common in patients with eosinophilic polyps; the association of bronchial asthma and eosinophilic polyps was weak; and no significant statistical association between eosinophilic polyps and aspirin sensitivity.…”

Section: Sakuma Et Al Concluded That Blood Eosinophilia Asthma Complmentioning

confidence: 94%

Chronic Eosinophilic Rhinosinusitis Clinical Implications

Abdulla¹,

Darwish²,

Bella³

2017

BMB

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Background: Eosinophilic Chronic Rhinosinusitis (ECRS) is clinically characterized by extensive disease and poor prognosis.Objectives: To evaluate eosinophilic mucin in Chronic Rhinosinusitis (CRS). Design: A Retrospective Study.Setting: Bahrain Defence Force Royal Medical Services, Bahrain.Methods: Fifty-nine patients with chronic rhinosinusitis with nasal polyps were included in the study. Clinical data, CT findings and histopathology were documented.Results: Twenty-six (44.1%) patients were diagnosed with eosinophilic chronic rhinosinusitis (ECRS) with nasal polyps. Headache, bilateral nasal polyps, total sinus opacification and occluded ostiomeatal complex were more common in patients with ECRS compared to patients with noneosinophilic CRS. P-value less than 0.05 was considered statistically significant. Bull 2017; 39(2): 92 -95 Conclusion: Patients with ECRS are likely to have severe disease presentation compared to patients with non-eosinophilic CRS. Clinical findings could differentiate ECRS from noneosinophilic CRS. Bahrain Med

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The Prevalence of Aspirin Hypersensitivity in Patients with Nasal Polyposis and Contributing Factors

Abstract: ASA hypersensitivity is quite common in patients with NP. Patients with extensive and long-term NP with multiple polyp operations require evaluation for the presence of ASA hypersensitivity in terms of chronic management and future risks of the disease.

Cited by 19 publications

References 37 publications

Respiratory hypersensitivity reactions to NSAIDs in Europe: the global allergy and asthma network (GA²LEN) survey

Respiratory hypersensitivity reactions to NSAIDs in Europe: the global allergy and asthma network (GA²LEN) survey

Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease

Chronic Eosinophilic Rhinosinusitis Clinical Implications

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The Prevalence of Aspirin Hypersensitivity in Patients with Nasal Polyposis and Contributing Factors

Abstract: ASA hypersensitivity is quite common in patients with NP. Patients with extensive and long-term NP with multiple polyp operations require evaluation for the presence of ASA hypersensitivity in terms of chronic management and future risks of the disease.

Cited by 19 publications

References 37 publications

Respiratory hypersensitivity reactions to NSAIDs in Europe: the global allergy and asthma network (GA2LEN) survey

Respiratory hypersensitivity reactions to NSAIDs in Europe: the global allergy and asthma network (GA2LEN) survey

Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease

Chronic Eosinophilic Rhinosinusitis Clinical Implications

Contact Info

Product

Resources

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Respiratory hypersensitivity reactions to NSAIDs in Europe: the global allergy and asthma network (GA²LEN) survey

Respiratory hypersensitivity reactions to NSAIDs in Europe: the global allergy and asthma network (GA²LEN) survey