The prevalence of anti-latex IgE antibodies in 1000 volunteer blood donors

Ownby, Dennis R.; Ownby, Helen E.; McCullough, Judith; Shafer, A. William

doi:10.1016/s0091-6749(96)70183-5

Cited by 168 publications

(80 citation statements)

References 15 publications

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“…Higher prevalences, determined by some authors (13,14), seems to be related with the diagnostic method used (SPT and/or serum specific IgE determination) and the existence of occupational exposure in the studied populations.…”

Section: Introductionmentioning

confidence: 71%

Risk factors for latex sensitization in children with spina bifida

Pires

Morais‐Almeida

Gáspár

et al. 2002

Allergologia et Immunopathologia

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SUMMARYBackground: Children with spina bifida represent the major risk group for latex sensitization.Purpose: To determine the prevalence of latex sensitization in these children and to identify risk factors.Material and methods: We studied 57 patients with spina bifida. The mean age was 5.6 years and the male/female ratio was 0.8/1. In all patients a questionnaire, skin prick test (SPT) with latex (UCBStallergènes, Lofarma and ALK-Abelló), common aeroallergens and fruits (UCB-Stallergènes) and serum determination of total IgE (AlaSTAT) were performed.Results: The prevalence of latex sensitization was 30 %; only two sensitized children (12 %) had symptoms after exposure. Risk factors for latex sensitization were age Ն 5 years (p = 0.008; OR = 6.0; 95 % CI = 1.7-22.1), having at least four previous surgical interventions (p < 0.0001; OR = 18.5; 95 % CI = 3.6-94.8), having undergone surgery in the first 3 months of life (p = 0.008; OR = 5.4; 95 % CI = 0.7-29.2) and total serum IgE Ն 44 IU/ml (p = 0.03; OR = 3.8; 95 %CI = 1.1-13.1). Multiple logistic regression analysis showed that only a history of four or more surgical interventions (p < 0.0001; OR = 26.3; 95 %CI = 2.9-234.2) and total serum IgE Ն 44 IU/ml (p = 0.02; OR = 8.6; 95 % CI = 1.4-53.4) were independently associated with latex sensitization. Sex, family and personal allergic history, hydrocephalus with ventriculoperitoneal shunt, cystourethrograms, intermittent bladder catheterization and atopy were not related to latex sensitization. Conclusions:In children with spina bifida, significant and independent risk factors identified for latex sensitization were multiple interventions and higher levels of total serum IgE. A prospective study will clarify the clinical evolution of assymptomatic children sensitized to latex.

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Section: Introductionmentioning

confidence: 71%

Risk factors for latex sensitization in children with spina bifida

Pires

Morais‐Almeida

Gáspár

et al. 2002

Allergologia et Immunopathologia

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“…Results showed a 6.4 percent positive response, which suggests a much higher prevalence in the general population than first presumed. 4 These results were basically replicated in another study, where the prevalence of latex sensitization in persons attending health screening was 6.6 percent. 5 …”

Section: General Populationmentioning

confidence: 74%

Review of Latex Allergy

Cheng¹,

Lee²

1999

The Journal of the American Board of Family Medicine

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“…The lower limit annual average ambient latex allergen concentration of 0.028 ng/m3 estimated above at community air monitoring sites is definitely lower than expected near freeways, on days with higher than average pollutant concentrations, or during the morning traffic peak. Peak ambient exposures are at least a factor of 10 higher, in the vicinity of FDA latex allergen equivalent 0.3 ng/m3.…”

Section: Resultsmentioning

confidence: 98%

“…Health-care workers exposed frequently to latex gloves show a high incidence (9-15%) (6)(7)(8) as do patients exposed to numerous surgeries such as those suffering from spina bifida (30-65%) (9). A recent survey of blood bank sera from the general adult population in Detroit, Michigan revealed the presence of anti-latex IgE antibody in 6.5% of the volunteers, thus indicating the potential for latex allergy in roughly 17 million individuals in this country (10). Tire production is now the largest application for natural rubber and accounts for 75% of the global consumption (11).…”

mentioning

confidence: 99%