Latex allergens in tire dust and airborne particles.

Miguel, Antonio H.; Cass, Glen R.; Weiss, Jay M.; Glovsky, M. Michael

doi:10.1289/ehp.961041180

Cited by 65 publications

(16 citation statements)

References 42 publications

(37 reference statements)

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“…[29][30][31] Heavy vehicles, as a major source of tyre debris in the sediment and of tyre dust in suspended particulate, could be directly responsible of latex allergy. 32 Stronger associations were found for children reporting severe asthmatic and bronchitic symptoms in the year before interview (table 4). This finding may simply reflect a better clinical specificity of the groups (less false positive subjects included), but also could be interpreted as confirmation of an increased susceptibility of the sicker children to environmental pollution.…”

Section: Interpretation Of Resultsmentioning

confidence: 94%

Road traffic and adverse respiratory effects in children. SIDRIA Collaborative Group.

et al. 1998

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Objectives-To investigate the relation between traYc indicators in the area of residence and the occurrence of chronic respiratory disorders in children. Methods-A population based survey was conducted in 10 areas of northern and central Italy (autumn 1994 to winter 1995) in two age groups (6-7 and 13-14 years). Information on several respiratory disorders and on traYc near residences was collected with a questionnaire given to children and to their parents. The sample analysed included 39 275 subjects (response rate 94.4%). Outcomes were: (a) early (first 2 years of life) respiratory diseases, and (b) current respiratory disorders (asthma, wheeze, cough, or phlegm in the past year). Odds ratios (ORs) and 95% confidence intervals (95% CIs), adjusted for several potential confounders, were estimated from logistic regression models. Main results were stratified by level of urbanisation (metropolitan areas, other centres). Results-In the metropolitan areas, high frequency of lorry traYc in the street of residence was associated with significantly increased risks for many adverse respiratory outcomes. Among early respiratory diseases, the strongest associations were found for recurrent bronchitis (OR 1.69, 95% CI 1.24 to 2.30), bronchiolitis (1.74, 1.09 to 2.77) and pneumonia (1.84, 1.27 to 2.65), although no association was detected for episodes of wheezing bronchitis. All the current respiratory disorders were positively and consistently associated with frequency of lorry traYc, particularly the most severe bronchitic and wheezing symptoms: persistent phlegm for >2 months (1.68; 1.14 to 2.48), and severe wheeze limiting speech (1.86; 1.26 to 2.73). No or weaker associations with heavy vehicular traYc were detected in urban and rural areas and no increased risks were found in the whole sample with the reported traYc density in the zone of residence. After extensive evaluations, the potential of reporting bias seems unlikely. Conclusion-Exposure to exhausts from heavy vehicular traYc may have several adverse eVects on respiratory health of children living in metropolitan areas, increasing the occurrence of lower respiratory tract infections early in life and of wheezing and bronchitic symptoms at school age. (Occup Environ Med 1998;55:771-778)

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Section: Interpretation Of Resultsmentioning

confidence: 94%

Road traffic and adverse respiratory effects in children. SIDRIA Collaborative Group.

et al. 1998

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“…11 Another more subtle effect of tire wear on human health may be the presence of latex allergens. 12 A recent epidemiological study revealed contemporaneous linear correlations between asthma mortality rates and radial-tire use, rather than with other traffic-related factors. 13 More recently, evidence that organic extracts from tire rubber can cause localized damage to the plasma membrane of human lung epithelial cells has been reported.…”

Section: ' Introductionmentioning

confidence: 99%

“…The samples, except for the pine-smoke, were extracted three times under ultrasonic agitation, 30 min each with 40 mL of a 2:1 mixture of dichloromethane (DCM) and methanol (MeOH). Smoke from the combustion of pine-needles and branches retained on a glass thimble was Soxhlet extracted with DCM/MeOH (95:5) for 24 h. Before extraction, the samples were spiked with a mixture of deuterated surrogates (i.e., octadecanoic acid-d 35 for the resin acids, and naphthalene-d 8 , anthracene-d 10 , p-terphenyl-d 14 , and benz[a]anthracene-d 12 for PAHs) to correct for losses during sample preparation.…”

Section: ' Introductionmentioning

confidence: 99%

Evaluation of Hydrogenated Resin Acids as Molecular Markers for Tire-wear Debris in Urban Environments

Kumata

Mori

Takahashi

et al. 2011

Environ. Sci. Technol.

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To propose new molecular markers for tire-wear emissions, four dihydroresin acids, that is, 8-isopimaren-18-oic acid (I), 8-pimaren-18-oic acid (II), 13β(H)-abieten-18-oic acid (III), and 13α(H)-abiet-8-en-18-oic acid (IV), were identified and investigated for source specificities, distributions, and environmental stabilities. The absence of I-IV in natural sources and the linear correlations between dihydroresin acids with different skeletons in tires and in environmental samples demonstrated that I-IV are specific markers for synthetic rubbers. The ratio of III + IV to the sum of III + IV plus abietic acid showed the resin acids distribution between different environmental compartments receiving contributions from traffic and natural sources. The physicochemical properties and results of photolysis experiments suggested that I-IV can set lower limits for tire-wear contributions to environmental loads of particulate matter (PM) and polycyclic aromatic hydrocarbons with molecular weight ≥202. By comparing III + IV concentrations or (III+IV)/pyrene or (III+IV)/benzo[a]pyrene ratios in tires and those in environmental matrices, the contributions of tire-wear emissions to PM, pyrene, and benzo[a]pyrene were estimated to be 0.68 ± 0.54%, 6.9 ± 4.8%, and 0.37 ± 0.18% in roadside PM and 0.83 ± 0.21%, 0.88 ± 0.52%, and 0.08 ± 0.06% in rooftop PM.

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“…In fact, several reports [23,54,55,60] refer to the presence of organic components that can be leached. The TD organic fraction, obtained by extraction in soxhlet apparatus and analysed with FTIR, contained isoprene as the principal chemical compound.…”

Section: Discussionmentioning

confidence: 99%

“…PM 10 [12,13], diesel exhaust particles (DEP) [14-17] and ultrafine particles [18,19] have received attention and been extensively analysed for their cytotoxicity, while the particulate deriving by tire abrasion on the road received a consideration limited to its impact on the soil, since it releases a large amount of zinc [20], and on the ambient air for its metal composition [21,22]. Previously, the presence of latex allergens in tire dust was suggested by Miguel et al [23], who outlined that this component could be an important factor in producing latex allergies and asthma symptoms.…”

Section: Introductionmentioning

confidence: 99%

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et al. 2005

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Background: It is estimated that over 80% of respirable particulate matter (PM 10 ) in cities comes from road transport and that tire and brake wear are responsible for the 3-7% emission of it. Data on the indicators of environmental impact of tire debris (TD), originated from the tire abrasion on roads, are extremely scarce, even though TD contains chemicals (zinc and organic compounds) which can be released in the environment.

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Latex allergens in tire dust and airborne particles.

Abstract: The prevalence and Severity of l ailergy has increased matically in the last 15

Cited by 65 publications

References 42 publications

Road traffic and adverse respiratory effects in children. SIDRIA Collaborative Group.

Road traffic and adverse respiratory effects in children. SIDRIA Collaborative Group.

Evaluation of Hydrogenated Resin Acids as Molecular Markers for Tire-wear Debris in Urban Environments

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