The prevalence, immunogenicity, and evanescence of alloantibodies to MUT and Mur antigens of GP.Mur red blood cells in a Southeast Asian patient cohort

Abstract

Antibodies to MUT and Mur develop following multiple RBC exposures. Immunogenicity of MUT/Mur and evanescence rates of the corresponding antibodies is higher compared to anti-E. Appropriate selection of antibody screening cells is needed in view of the high prevalence, immunogenicity, and evanescence of the antibodies.

Fetal inheritance of GP*Mur causing severe HDFN in an unrecognized case of maternal alloimmunization

“…The antigens in the MNS blood group system expressed from hybrid glycophorins A and B (formerly known as the Miltenberger series) are such an example, many of which are prevalent among Southeast Asians. 6 We found anti-Mi a in a patient with a pregnancy ABBREVIATIONS: DAT = direct antiglobulin test; GA = gestational age; HDFN = hemolytic disease of the fetus and newborn; MCA = middle cerebral artery; PSV = peak systolic velocity. history that included spontaneous losses and a stillborn from her eighth pregnancy that, in retrospect, had physical features of hemolytic disease of the fetus and newborn (HDFN).…”

“…Alloimmunization to hybrid A/B glycophorin antigens is reported to be approximately 0.3% in Southeast Asia . The morbidity and mortality risk to the newborn and subsequent pregnancies are significant, as is the management and postnatal options as outlined to this patient.…”

“…11,13,16 Alloimmunization to hybrid A/B glycophorin antigens is reported to be approximately 0.3% in Southeast Asia. 6,11,13 The morbidity and mortality risk to the newborn and subsequent pregnancies are significant, as is the management and postnatal options as outlined to this patient. In North America, the antibody is not detected routinely because screening cells used in the laboratory are not Mi(a+).…”

“…The inheritance of some blood group antigens is restricted to certain ethnicities, some of which occur with relatively common frequency. The antigens in the MNS blood group system expressed from hybrid glycophorins A and B (formerly known as the Miltenberger series) are such an example, many of which are prevalent among Southeast Asians . We found anti‐Mi a in a patient with a pregnancy history that included spontaneous losses and a stillborn from her eighth pregnancy that, in retrospect, had physical features of hemolytic disease of the fetus and newborn (HDFN).…”

Prevalence of GP. Mur variant phenotype among Malaysian blood donors

“…Mur are typically associated with hemolytic transfusion reaction and hemolytic disease of the fetus and newborn,[ 7 8 9 10 33 ] and these antibodies are commonly found in East and Southeast Asian populations. [ 10 34 35 36 37 ] In Malaysia, a retrospective study showed that the antibodies to MNS variants (Mi a , MUT, and Mur antigens) increased from 0.94% (2004–2008 years) to 5.82% (2009–2010 years). [ 38 ] In another study, anti-MUT and anti-Mur were detected in alloimmunized patients with a prevalence of 5.0% and 0.7%, respectively.…”