The prevalence, awareness, treatment, and control of dyslipidemia in northeast China: a population-based cross-sectional survey

Zhang, Fu-Liang; Xing, Yingqi; Wu, Yanhua; Liu, Hao-Yuan; Luo, Yun; Sun, Ming-Shuo; Guo, Zhen‐Ni; Yang, Yi

doi:10.1186/s12944-017-0453-2

Cited by 66 publications

(64 citation statements)

References 37 publications

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“…A nationwide investigation showed that the prevalence of dyslipidemia was 34.7% among Chinese adults over age 35 years [17] , which was higher than the results of the current study. However, compared with several regional studies [18][19][20] , the prevalence of decreased HDL-C and elevated TG in our study were at higher levels. The epidemiological data showed that HDL-C levels were negatively correlated with the risk of atherosclerotic cardiovascular disease (ASCVD) [21] , and elevated TG was commonly associated with increased CVD risk [22] .…”

Section: Discussioncontrasting

confidence: 83%

Prevalence of dyslipidemia and associated risk factors among adults aged ≥ 35 years in northern China: a cross-sectional study

Xi¹,

Niu

Cao

et al. 2020

Preprint

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Background: Cardiovascular disease (CVD) prevalence has increased continuously over the last 30 years in China. Dyslipidemia is an important modifiable risk factor in CVD. We aimed to collect current data on the prevalence of dyslipidemia in northern China and explore potential influencing factors.Methods: In this cross-sectional study, we selected a representative sample of 65,128 participants aged ≥35 years in Inner Mongolia during 2015–2017. All participants completed a questionnaire and were examined for risk factors. Dyslipidemia was defined according to 2016 Chinese guidelines for adults. The associated factors for dyslipidemia were estimated by multivariate logistic regression analysis.Results: The age-standardized prevalence of dyslipidemia was 31.2% overall, with 4.3%, 2.4%, 14.7%, and 17.4% for high total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and low high-density lipoprotein cholesterol (HDL-C), respectively. The dyslipidemia prevalence was significantly higher in men than women (37.9% vs. 27.5%, P<0.001), but postmenopausal women had a higher prevalence of dyslipidemia components (except low HDL-C). Compared with Han participants, Mongol participants had a lower prevalence of dyslipidemia (29.1% vs. 31.4%, P<0.001). Male sex, living in urban areas, Han ethnicity, smoking, obesity, central obesity, hypertension, and diabetes were significantly associated with higher risk of dyslipidemia; alcohol consumption was linked to lower risk of dyslipidemia.Conclusions: Our study revealed that dyslipidemia is a health problem in northern China. Greater efforts to prevent and manage dyslipidemia, especially in men under age 55 years, postmenopausal women, and people with unhealthy lifestyles or chronic diseases.

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Section: Discussioncontrasting

confidence: 83%

Prevalence of dyslipidemia and associated risk factors among adults aged ≥ 35 years in northern China: a cross-sectional study

Xi¹,

Niu

Cao

et al. 2020

Preprint

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“…Dyslipidemia, one of the pathophysiological characteristics in obese patients, includes high levels of plasma TC and TG, low levels of HDL, and is key in the development of CVD in obese patients (12). For example, in a large series of 26,000 overweight children, 14.1% of patients had abnormal TC levels, 15.8% of patients had abnormal LDL-C, 11.1% of patients had abnormal HDL-C and 14.3% of patients had abnormal TG levels (13).…”

Section: Discussionmentioning

confidence: 99%

Exercise improves high fat diet-impaired vascular function

Fang

Tang

2017

Biomedical Reports

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Abstract. The prevalence of metabolic syndrome and cardiovascular disease is increasing due to increases in the consumption of high fat diets (HFDs) and the epidemic of obesity. In the present study, it was hypothesized that swimming exercise may prevent HFD-induced impairment of aortic function and that these changes are associated with reduction of oxidative stress, proinflammatory adipokines/cytokines. Male, 6-week-old C57BL/6J mice were fed a 60% lipid composition HFD with or without swimming exercise (90 min/swim and 2 swims/day) for 16 weeks. Exercise training prevented HFD-induced increases in visceral fat weight, total cholesterol and triglycerides. Furthermore, exercise training improved HFD-impaired aortic endothelium-dependent dilation that was associated with reduction of oxidative stress, leptin, resistin, monocyte chemoattractant protein 1, interleukin (IL)6 and IL8. In addition, exercise inhibited HFD-induced vascular endothelial growth factor expression in gastrocnemius skeletal muscle. These data demonstrate that swimming exercise prevents aortic tissue oxidative stress, inflammation and vascular dysfunction in HFD-induced obesity.

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“…In addition, the prevalence rate of dyslipidemia varies by region due to different climatic environments, diets, and lifestyles. In an epidemiology study, a high prevalence of dyslipidemia was found among adults in Northeast China, especially in urban areas [15]. The study results also indicated that high TG was the most prevalent type of dyslipidemia in Northeast China, followed by high TC [15].…”

Section: Discussionmentioning

confidence: 82%

“…However, the associations between other serum vitamins and lipid profiles have not been investigated. In addition, high TG levels were suggested in a previous study as the most prevalent type of dyslipidemia in Northeast China, followed by high TC levels [15]. Thus, the present study was designed to explore the associations between various serum vitamin concentrations and serum lipid profiles, including serum TC, TG, HDL-C, and LDL-C levels in a healthy Northeast China population.…”

Section: Introductionmentioning

confidence: 92%

Associations between serum vitamins and serum lipids in healthy Northeast China adults

Li¹,

Xia

et al. 2019

Preprint

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Objective In previous studies, serum vitamins were shown associated with lipid levels. However, evidence regarding the associations between various serum vitamins and serum lipids is limited. Therefore, the associations between serum vitamins and serum lipids were investigated in this cross-sectional study.Methods The study population included 131 adults (42 males and 89 females) ≥ 18 years of age who lived more than three years in Shenyang, Liaoning province, China. Serum lipids included total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Analysis of covariance was used to explore the associations between serum vitamins and serum lipids.Results After multiple adjustments, vitamin A and vitamin C concentrations were positively associated with LDL-C level ( P for trend < 0.05). Vitamin A, vitamin B5, and vitamin C concentrations were positively associated with TG level ( P for trend < 0.05). However, vitamin B1 concentration was negatively associated with TG level ( P for trend = 0.04). Vitamin E concentration was positively associated with HDL-C level ( P for trend = 0.02). No association was observed between vitamin concentrations and TC level.Conclusion The results in the present study indicate that serum vitamin concentrations are associated with serum lipid levels. Vitamin B1 and vitamin E concentrations were associated with a better status of lipid profiles. However, vitamin A, vitamin C, and vitamin B5 concentrations were associated with a worse status of lipid profiles.

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The prevalence, awareness, treatment, and control of dyslipidemia in northeast China: a population-based cross-sectional survey

Cited by 66 publications

References 37 publications

Prevalence of dyslipidemia and associated risk factors among adults aged ≥ 35 years in northern China: a cross-sectional study

Prevalence of dyslipidemia and associated risk factors among adults aged ≥ 35 years in northern China: a cross-sectional study

Exercise improves high fat diet-impaired vascular function

Associations between serum vitamins and serum lipids in healthy Northeast China adults

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