The prevalence and characteristics of congenital pigmented lesions in newborn babies in Oxford

Goss, B.D.; Forman, David; Ansell, Pat; Bennett, Vernon; Swerdlow, Anthony; Burge, Susan; Ryan, T.J.

doi:10.1111/j.1365-3016.1990.tb00672.x

Cited by 29 publications

(8 citation statements)

References 22 publications

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“…Studies on birthmarks in newborn babies have been previously performed in the USA [6,7,8], Brazil [9] and some European countries [10,11,12,13,14,15]. The frequency of CMN ranged between 0.2 and 6% in these works.…”

Section: Discussionmentioning

confidence: 99%

Congenital Melanocytic Nevus: An Epidemiologic Study in Italy

Ingordo¹,

Gentile²,

Iannazzone³

et al. 2007

Dermatology

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Background: The prevalence of congenital melanocytic nevi (CMN) among newborns ranges between 0.2 and 6% in the worldwide literature. In the only available study from Italy the rate was 1% at birth and 1.4% at 2 years of age. Some surveys performed among samples of children and adolescents in other countries showed a prevalence which ranged from 1.4 to 4.4%. Additional data on the frequency in adults are not available. Objective: The aim of this study was to estimate the prevalence of CMN in a large sample of a young male Italian population, which is deemed to be representative of the general population of the same age and sex. Methods: The potential conscripts resident in the coastal regions of southern Italy, enlisted for the compulsory service in the Italian Navy, were called at the age of 18 to the Draft’s Council Medical Unit of the Italian Navy in Taranto to evaluate their psychophysical fitness to recruitment. All the subjects examined from September 2002 to March 2004 showing skin lesions evocative of CMN were referred by general practitioners of the Draft’s Council Medical Unit to the Department of Dermatology of the Italian Navy Hospital for confirming the diagnosis, which was based on the clinical features and the personal history. The confirmed cases were recorded in a predefined patient card, containing the main anamnestic and clinical data. Since the screening of small CMN in such a large sample of subjects was believed to be difficult, only CMN with a diameter ≧1.5 cm were recorded. Results: In 23,354 examined persons 157 CMN were diagnosed, with a prevalence of 0.67% (Bayesian 95% confidence interval 0.57–0.79); 126 (80.3%) CMN were medium-sized (≧1.5 and ≤19.9 cm in diameter), and 31 (19.7%) were large (≧20 cm in diameter). Three CMN (1.9%) were located on the face, 23 (14.6%) on the chest, 24 (15.2%) on the abdomen, 36 (22.9%) on the back, 48 (30.5%) on the lumbar area, 15 (9.5%) on the upper limb, 19 (12.1%) on the lower limb and 15 (9.5%) on the shoulder. No CMN was located on the head. In 19 cases (12.1%) ≧2 adjacent anatomical sites (shoulder/chest, shoulder/arm, etc.) were involved. In 73 moles (46.4%) terminal hairs were present. Eight CMN (5.1%) showed a zosteriform (i.e. segmental) feature. None of the examined subjects reported a personal history of malignant melanoma (MM), and no person with a history of MM was observed among all the enlisted men referred to the Department of Dermatology during the time of the study. Conclusion: The prevalence of CMN in the Italian young male general population is roughly in agreement with the rates detected in general populations from other European studies. The observations of this study also suggest that the risk of appearance of MM, at least in childhood and adolescence, is limited for medium-sized CMN.

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Section: Discussionmentioning

confidence: 99%

Congenital Melanocytic Nevus: An Epidemiologic Study in Italy

Ingordo¹,

Gentile²,

Iannazzone³

et al. 2007

Dermatology

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“…The findings at birth have been reported. 17 We identified children from this original study still resident in Oxfordshire by matching maternal names and child's date of birth with the Family Health Services Authority (FHSA) general practitioner registration records.…”

Section: Methodsmentioning

confidence: 99%

Maternal and child constitutional factors and the frequency of melanocytic naevi in children

Graham¹,

Fuller²,

Murphy³

et al. 1999

Paediatric Perinatal Epid

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This study examined the association between numbers of benign melanocytic naevi in 7-year-old children in Oxfordshire born in 1988-9 with their mother's arm naevus count, and maternal and child pigmentation factors. We believe this is the first time that the relationship between child and maternal naevus counts has been reported. A high naevus count in the child was associated with male sex (P = 0.009), freckling (P = 0.001) and propensity of the child to burn in the sun (P = 0.05). A low naevus count was observed in red-haired children (P = 0.02). The strongest association of child's naevus count was with a high maternal arm naevus count, independent of the child's pigmentation factors (trend P < 0.0001). Maternal pigmentation factors were not associated with child's naevus count independent of the child's own pigmentation factors. Maternal arm naevus counts may be a better predictor of child naevus count than the child's own pigmentation factors and children. There has not been examination, however, of the relationship between naevus counts in children and those in their parents. We therefore conducted a study of the occurrence of naevi in children aged 7-8 years in Oxfordshire, examining, in addition to sex and pigmentation factors in the child, the relationship of maternal pigmentation factors and maternal naevus counts with naevi in their offspring.

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“…The estimated prevalence of CMN varies widely depending on the study, ranging from 0.5% to 31.7%. 6,[23][24][25][26][27][28][29][30][31] Most are \3 to 4 cm in diameter. Larger ones are less common.…”

Section: Clinical Presentation Key Pointsmentioning

confidence: 99%