The presynaptic active zone: A dynamic scaffold that regulates synaptic efficacy

Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders

“…Furthermore, interactors with most of the synaptic proteins have been identified, allowing the construction of an intricate protein network. Despite the latter, to translate this protein network into synapse function and efficacy is a complex task because some protein-protein interactions are more stable while others are temporal in response to plasticity events [6–8]. Furthermore, some proteins have diverse isoforms with a spatial-temporal expression pattern that sometimes partially overlaps.…”

Fife organizes synaptic vesicles and calcium channels for high-probability neurotransmitter release

“…The observation that the presynaptic parameters of synaptic strength vary significantly even between the synapses of an individual neuron indicates that neurotransmitter release properties are determined locally at active zones and raises the question of how this complex regulation is achieved (Rosenmund et al, 1993;Murthy et al, 1997;Guerrero et al, 2005;Ariel et al, 2013;Melom et al, 2013). Genetic studies in Drosophila, Caenorhabditis elegans, and mice are revealing a key role for the active zone cytomatrix in determining the functional parameters underlying synaptic strength (Ackermann et al, 2015;Michel et al, 2015). A mechanistic understanding of how the active zone cytomatrix achieves local control of synaptic release properties will yield fundamental insights into neural circuit function.…”

Role of Actin Filament on Synaptic Vesicle Pooling in Cultured Hippocampal Neuron

“…Synapses create, receive, and transport electrical signals to target cells through neurotransmitters (Shupliakov et al, 2011;Südhof, 2012). Fusion of neurotransmitter stored in synaptic vesicles affects a remarkable area of the pre-synaptic membrane (Greengard et al, 1993;Michel et al, 2015). Synaptic vesicle's life cycle is composed of docking, priming, fusion and recycle and this cycle is regulated by environmental condition and various stimulus (Greengard et al, 1993;Michel et al, 2015;Rizzoli & Betz, 2005).…”