The preservation of ovarian function in young women undergoing pelvic radiation therapy

Fertility Preservation for Young Women with Rectal Cancer—A Combined Approach from One Referral Center

“…Only 11-13% experienced ovarian failure below 300 cGy versus 60-63% above that threshold value. 10 The radiation doses to the ovaries with standard pelvic irradiation for colorectal cancer (50-65 Gy) will uniformly induce ovarian failure. With shielding over the ovaries and uterus, the total ovarian dose of radiation is reduced to 8-15%; however, there may be scatter and transmission through the shield.…”

Reproductive organ transplantation: advances and controversies

“…Single-dose radiation is more toxic than fractionated regimens (25). The break point for radiation-induced ovarian failure is approximately 300 cGy to the ovaries, only 11% to 13% experience ovarian failure below 300 cGy, while 60% to 63% will do so above this threshold value (31). Uterine dysfunction has been also reported to follow radiation doses between 14 and 30 Gy (32)(33)(34).…”

Effects of cancer treatment on ovarian function

“…Transfixing the ovaries out of the radiation fields before therapy, a procedure called oophoropexy or ovarian transposition, can increase the chance of preserving ovarian function by allowing better sparing of the ovaries from the harmful effects of irradiation. Historically, rates of cessation of ovarian function after transposition alone have been reported to be as high as 40% (53)(54)(55)(56). However, laparoscopic techniques have been used to minimize operative morbidity (57,58).…”