The presence of RNA complementary to HSV‐2 (herpes simplex virus) DNA in cervical intraepithelial neoplasia after laser therapy

Eglin, Roger; Kitchener, HC; MacLean, Allan; Denholm, R. B.; Cordiner, J. W.; Sharp, F.

doi:10.1111/j.1471-0528.1984.tb04765.x

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…Chen and colleagues showed that cervical carcinoma could be induced in 50% of mice after repeated intravaginal inoculation with inactivated HSV-2 and that malignant transformation could be prevented by administration of a subunit vaccine [24]. However, studies utilizing immunocytochemical and DNA hybridization techniques have not consistently demonstrated HSV antigen or DNA in tumor tissue sampled from women with cervical carcinoma [25][26][27][28]. The role of HSV may be one of an initiator or enhancer of oncogenic transformation, possibly in combination with other factors.…”

Section: Natural History and Sequelae: Cervical Carcinomamentioning

confidence: 99%

Cervical carcinoma as a sexually transmitted disease: human papillomavirus and its possible etiologic role

Benson

1987

Adv Contracept

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Historical perspectiveBeginning in the late 15th century, genital warts, and in fact many unexplained genital lesions, were attributed to an outbreak of syphilis occurring in Europe during the time [1]. Gonorrhea was later proposed as an etiology of genital warts. It was not until the discovery of the gonococcus in 1879 that this was refuted. The then new theory proposed that warts resulted from genital irritation caused by secretions 'disordered through venery', and led to the coining of the term venereal warts [1]. The viral etiology of skin warts was recognized in 1949 and it was not until 20 years later that viral particles were demonstrated microscopically in genital and anal warts [1].Rubin, in 1910, while examining histologic specimens from patients, noted abnormal cellular morphologic changes in clinically normal appearing tissue [2]. He proposed the concept that not only tissue invasion but also intrinsic cellular morphology could be determinants of neoplastic transformation [2]. The significance of lesions that were not invasive but were morphologically abnormal was hotly debated over the ensuing two decades until the concept of carcinoma in situ was introduced by Broder in 1932 [3]. The perfection and widespread use of the Papanicolao u (Pap) smear established the importance of these early lesions on a mass scale. Structure and biology of human papillomavirusHuman papillomavirus (HPV), the etiologic agent of genital warts, is a nonenveloped DNA virus with an icosahedral capsid of 50-55 n in diameter containing 72 capsomeres [4]. The HPV genome exists in three forms within virions and infected cells: (1) a covalenfly closed circular supercoiled form; (2) an open circular form; and (3) a linear form [4]. All forms may exist as non-integrated plasmids in both benign and malignant lesions although DNA hybridization studies have also demonstrated integrated HPV genome within host cell nuclei. 103 Advances in Contraception. ISSN 0267-4874.

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Section: Natural History and Sequelae: Cervical Carcinomamentioning

confidence: 99%

Cervical carcinoma as a sexually transmitted disease: human papillomavirus and its possible etiologic role

Benson

1987

Adv Contracept

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Is Human Papillomavirus a Primary Factor in the Causation of Cervical Neoplasia? Does Herpes Simplex Virus Play a Subordinate Role?

Aurelian¹

1989

Journal of Gynecologic Surgery

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Healing of cervical epithelium after laser treatment of cervical intraepithelial neoplasia

MacLean¹

1984

BJOG

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The recognition that only a minority of cervical premalignant lesions progress to invasion, and the increasing incidence of these lesions in young women, has led to a more conservative approach in the treatment of cervical intraepithelial neoplasia. One such method uses the carbon dioxide laser but inadequate length of follow-up has prevented a prediction of risk of recurrence. Observations made in this study on the speed of healing, source of new epithelium, maturation of the epithelium and the absence of herpes nucleic acid suggest that this risk is low.

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The presence of RNA complementary to HSV‐2 (herpes simplex virus) DNA in cervical intraepithelial neoplasia after laser therapy

Cited by 4 publications

References 9 publications

Cervical carcinoma as a sexually transmitted disease: human papillomavirus and its possible etiologic role

Cervical carcinoma as a sexually transmitted disease: human papillomavirus and its possible etiologic role

Is Human Papillomavirus a Primary Factor in the Causation of Cervical Neoplasia? Does Herpes Simplex Virus Play a Subordinate Role?

Healing of cervical epithelium after laser treatment of cervical intraepithelial neoplasia

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