Healing of cervical epithelium after laser treatment of cervical intraepithelial neoplasia

Abstract

The recognition that only a minority of cervical premalignant lesions progress to invasion, and the increasing incidence of these lesions in young women, has led to a more conservative approach in the treatment of cervical intraepithelial neoplasia. One such method uses the carbon dioxide laser but inadequate length of follow-up has prevented a prediction of risk of recurrence. Observations made in this study on the speed of healing, source of new epithelium, maturation of the epithelium and the absence of herpes nucleic acid suggest that this risk is low.

Cost‐effectiveness of human papillomavirus testing after treatment for cervical intraepithelial neoplasia

“…30 In order to limit the number of colposcopies, an attractive strategy would be to perform HPV testing alone at 6 months and both HPV and cytological testing at 24 months. examinations that do not lead to detection of CIN2/3, were most common for HPV strategies with cytological testing at 6 months.…”

Addition of high-risk HPV testing improves the current guidelines on follow-up after treatment for cervical intraepithelial neoplasia

“…Three months after treatment only 26% of the women with a high-risk HPV-positive test at baseline still had a positive high-risk HPV test, indicating that in most women treatment resulted in eradication of high-risk HPV. Cervical cytology was abnormal in 17% of the women, but it is known that reading cervical smears 3 months after ablative treatment is difficult because of the 'repaireffect' (Maclean, 1984).…”

Cervical healing and Langerhans' cells

“…After restoration of the cover with columnar and immature squamous epithelium, squamous metaplasia and maturation occurred. The details of healing are described in full elsewhere (MacLean 1984).…”

“…Forty-five patients who had undergone laser treatment to the cervix were studied at intervals between 5 and 50 days after treatment. Colpophotographs and punch biopsies were taken; the biopsies were processed for light and transmission electron microscopy, and for histochemistry as described previously (MacLean 1984).…”