The presence of histamine in the tissues of Ascaris suum

Phillips, Jean L.; Sturman, G.; West, G. B.

doi:10.1016/0306-3623(75)90027-0

Cited by 10 publications

(6 citation statements)

References 6 publications

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“…Other biogenic amines which may have a transmitter and/or metabolic role in nematodes include noradrenaline, adrenaline, 5-hydroxytryptamine (5-HT) and histamine. These compounds have been detected in various nematodes (see Phillips et al, 1975;Goh & Davey, 1976a;Kisiel et al, 1976) but so far not all in the same species and their distribution remains uncertain. For example, noradrenaline, adrenaline and 5-HT are apparently present in C. briggsae but noradrenaline and adrenaline could not be detected in the closely related C. elegans.…”

Section: Discussionmentioning

confidence: 99%

“…5-HT has been proposed as an alternative candidate to y-aminobutyric acid for the inhibitory transmitter at the nematode neuromuscular junction (Anya, 1973b), although the latter is still considered by Jarman (1976) to be the most likely compound to fill this role. Recently histamine has also been proposed as a possible inhibitory transmitter (Phillips et al, 1975).…”

Section: Discussionmentioning

confidence: 99%

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Catecholaminergic structures in the nervous system of three nematode species, with observations on related enzymes

Wright¹,

Awan²

1978

Journal of Zoology

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The formaldehyde fluorescence technique has been used to demonstrate amine‐specific fluorescence in the nervous system of three nematode species, Prionchulus punclatus Cobb, Panagrellus redivivus Goodey, and Aphelenchus avenae Bastian. Examination of some of the physical and chemical properties of this fluorescence has shown it to be due principally to the primary catecholamine dopamine. Dopamine and dopa decarboxylase were also detected biochemically in A. avenae. Dopamine has now been proposed as a putative neurotransmitter in a number of nematode species and the role of this and other biogenic amines in nematodes is discussed. Of the two principal enzymes involved in the metabolism of monoamines, catechol‐O‐methyltransferase was detected in both A. avenae and P. redivivus but monoamine oxidase could not be detected in these or other nematode species.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Catecholaminergic structures in the nervous system of three nematode species, with observations on related enzymes

Wright¹,

Awan²

1978

Journal of Zoology

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“…Drugs were added to the Ringer solution at the start of the incubation. The Ascaris were then washed 6 times with drug-free Ringer solution, dried, stunned, weighed and the histamine extracted into n-butanol prior to assay fluorimetrically (Shore, Burkhalter & Cohn, 1959) and biologically (Phillips et al, 1975a). In other experiments, whole Ascaris, after incubation and stunning, were carefully dissected into head and body wall, intestines, reproductive tract and perienteric fluid before being weighed, extracted and assayed.…”

Section: Methodsmentioning

confidence: 99%

“…The natural excitatory transmitter may be acetylcholine (Gerschenfeld, 1973) but the inhibitory transmitter is still not known. Histamine has been proposed as an inhibitor for it occurs in the tissues of Ascaris and is concentrated in the neuromuscular structures (Miyagawi, 1961;Phillips, Sturman & West, 1975a). Furthermore, histamine inhibits acetylcholine-induced contractures of muscle preparations of Ascaris.…”

Section: Introductionmentioning

confidence: 99%

THE INTERACTION BETWEEN ANTHELMINTIC DRUGS AND HISTAMINE IN Ascaris suum

Phillips¹,

Sturman²,

West³

1976

British J Pharmacology

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Piperazine reduced the histamine content of Ascaris suum, yet it greatly increased the uptake of histamine from the surrounding medium, the neuromuscular structures of the nematode preferentially increasing in amount. Bephenium reduced the histamine content of Ascaris and the uptake of histamine from the surrounding medium. However, the relative amount in the neuromuscular structures increased. The flaccid paralysing action of piperazine may thus involve increased histamine absorption whereas the spastic paralysing action of bephenium may be independent of histamine.

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“…This intestinal nematode of endotherms has a diverse bacterial community within its own guts and many of these bacteria secrete the hormone serotonin, which is considered to stimulate glycogen metabolism (Hsu et al, 1986). This monoamine, like serotonin, is associated with stimulating glycogenolysis (Brownlee et al, 1994) and in bacterial-free conditions significantly lower concentrations are found in parasite tissues (Philips et al, 1975;Hsu et al, 1986). It is possible these bacteria may also be providing substantial amounts of supplementary histamine for the nematode.…”

Section: Physiology Of the Helminth -Bacterial Associationmentioning

confidence: 99%

Symbiotic bacteria of helminths: what role may they play in ecosystems under anthropogenic stress?

Morley

2016

J. Helminthol.

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Symbiotic bacteria are a common feature of many animals, particularly invertebrates, from both aquatic and terrestrial habitats. These bacteria have increasingly been recognized as performing an important role in maintaining invertebrate health. Both ecto- and endoparasitic helminths have also been found to harbour a range of bacterial species which provide a similar function. The part symbiotic bacteria play in sustaining homeostasis of free-living invertebrates exposed to anthropogenic pressure (climate change, pollution), and the consequences to invertebrate populations when their symbionts succumb to poor environmental conditions, are increasingly important areas of research. Helminths are also susceptible to environmental stress and their symbiotic bacteria may be a key aspect of their responses to deteriorating conditions. This article summarizes the ecophysiological relationship helminths have with symbiotic bacteria and the role they play in maintaining a healthy parasite and the relevance of specific changes that occur in free-living invertebrate-bacteria interactions under anthropogenic pressure to helminths and their bacterial communities. It also discusses the importance of understanding the mechanistic sensitivity of helminth-bacteria relationships to environmental stress for comprehending the responses of parasites to challenging conditions.

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The presence of histamine in the tissues of Ascaris suum

Cited by 10 publications

References 6 publications

Catecholaminergic structures in the nervous system of three nematode species, with observations on related enzymes

Catecholaminergic structures in the nervous system of three nematode species, with observations on related enzymes

THE INTERACTION BETWEEN ANTHELMINTIC DRUGS AND HISTAMINE IN Ascaris suum

Symbiotic bacteria of helminths: what role may they play in ecosystems under anthropogenic stress?

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