THE INTERACTION BETWEEN ANTHELMINTIC DRUGS AND HISTAMINE IN <i>Ascaris suum</i>

Phillips, Jean L.; Sturman, G.; West, G. B.

doi:10.1111/j.1476-5381.1976.tb07683.x

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…Effectofhistamine on membranepotential and input conductance Phillips et al (1976) have reported that piperazine affects the uptake of histamine by the parasite and that histamine may be an inhibitory transmitter. Histamine was therefore applied iontophoretically to the bag and in the bath in concentrations up to 10-3 M with little or no effect on the membrane potential or input conductance.…”

Section: Iontophoresis Of Acetylcholinementioning

confidence: 99%

“…Aubry et al (1970) were unable to further the argument as to whether piperazine should best be considered to act as an inhibitory transmitter or as a cholinoceptor antagonist as originally suggested by Norton & De Beer (1956). Further, Phillips, Sturman & West (1976) have suggested that piperazine acts by increasing the absorption of histamine by the parasite and that histamine may be an inhibitory transmitter. Added to this, Broome (1962) has reported that the piperazine derivative, diethylcarbamazine, has an excitatory not an inhibitory action on the contractility of the Ascaris nerve muscle preparation.…”

Section: Introductionmentioning

confidence: 99%

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ELECTROPHYSIOLOGICAL EFFECTS OF PIPERAZINE AND DIETHYLCARBAMAZINE ON Ascaris suum SOMATIC MUSCLE

Martin

1982

British J Pharmacology

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1 Electrophysiological recordings were made from the bag region of Ascaris suum muscle. Membrane potential and input conductance or membrane current under voltage clamp were measured. 2 In high-Cl-Ringer, bath-applied piperazine, at concentrations greater than 10-4 M, produced a dose-dependent and reversible increase in input conductance associated with a hyperpolarizing potential. The increase in input conductance was reduced when the preparations were bathed in low-Cl-Ringer. y-Aminobutyric acid (GABA) and piperazine reversal potentials were measured with a voltage clamp on the same cells using iontophoretic application of the agonists. The reversal potentials were the same and close to the predicted Nernst Cl-potential (-65 mV). When GABA and piperazine were applied simultaneously piperazine reversibly reduced the amplitude of the control outward GABA current response. It was concluded that piperazine acts as a GABA agonist of low potency on the extra-synaptic GABA receptors of the bag, mediating an increase in Clconductance.

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Section: Iontophoresis Of Acetylcholinementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ELECTROPHYSIOLOGICAL EFFECTS OF PIPERAZINE AND DIETHYLCARBAMAZINE ON Ascaris suum SOMATIC MUSCLE

Martin

1982

British J Pharmacology

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“…Tetramisole also inhibits the cholinesterase, aldolase and acid phosphatase of Ascaridia galli (Vertinskaya et al 1972;Chakraborty et al 1976). Piperazine has been reported to decrease glyc ogen value in Ascaris lumbricoides tissues (Abdulazizov 1975;Bogoyavlenski et al 1975) and histamine content in Ascaris suum (Phillips et al 1976).…”

Section: Disclissiodmentioning

confidence: 99%

Histochemical changes inSetaria cervi caused by certain anthelmintics

Baqui

1982

Proc Ani Sci

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The present study deals with the preliminary ill vivo screening of suramin and Ievamisole 1Il rei-Setaria cervi system with special reference to the histochemical changes in the adult worms caused by the drugs. Levamisole proved to be highly effective as a micro-and macro-filaricidal agent. It also appears to be interfering with the normal activity of alkaline phosphatase and' glycogen of the adult worms with no apparent effect on its protein content. The drug also causes irreversible paralysis in adult worms. Suramin, though an active pharmacological agent, proved to be completely ineffective 011 microfilariae as wcll as on adult worms of Setaria cervi. Consequently, no notable alterations in the histochemistry of the parasite following suramin treatment were observed.

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“…The excitatory neurotransmitter is acetylcholine, and the probable inhibitory transmitter is gammaaminobutyric acid (GABA) (Debell e t al., 1963;del Castillo, Mello & Morales, 1963, 1964a. Histamine (Miyagawi, 1961) has been found in Ascaris, but its function is unknown, although Phillips, Sturman & West (1976) have proposed that histamine is an inhibitory neurotransmitter, From this scanty information, we might conclude that cestodes and trematodes may be targets for one type of neuromuscular interference, and nematodes a target for a different class of compounds affecting neuromuscular transmission. Much information is needed, however, about many other helminths before any generalizations can be drawn.…”

Section: Ascaris Lum Bricoidesmentioning

confidence: 99%

Mode of action of common anthelmintics

Rew

1978

Vet Pharm & Therapeutics

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The primary physiological mode of action of nearly all drugs used to control helminth parasites is not well understood. Examination of the general modes of action in terms of parasite requirements for survival may, however, provide guidelines to continue our present investigations and direct us for future research. Two general areas of drug activity are (1) interference with energy‐generating metabolism, and (2) interference with proper neuromuscular coordination. Few exceptions are found to these areas because the target organisms require little else for survival. The target of most previously effective and many presently effective anthelmintics is an adult parasite. Adult helminth parasites must maintain an advantageous feeding site and must transport and metabolize substrates (primarily glucose) to generate life‐maintaining energy. Adult worms have almost no other short‐term requirements for survival because they have little or no metabolic activity in either lipid synthesis or oxidation, nucleic acid synthesis, or protein synthesis (except egg‐laying). Examination of specifics of energy‐generating metabolism and putative neurochemical transmitters allows us certain predictions in relating a given drug activity to an individual species. These examinations indicate that such diversity exists among helminth metabolic or nervous systems that a broad‐spectrum anthelmintic would most likely inhibit at several sensitive points. Published information on drug action and differences in data interpretation are discussed. Two novel areas for future anthelmintic investigations may be (1) juvenile hormone or ecdysone analogs, and (2) pheromones. A combined empirical and rational approach to the development of new drugs may be the most efficient avenue of future research.

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THE INTERACTION BETWEEN ANTHELMINTIC DRUGS AND HISTAMINE IN Ascaris suum

Cited by 8 publications

References 8 publications

ELECTROPHYSIOLOGICAL EFFECTS OF PIPERAZINE AND DIETHYLCARBAMAZINE ON Ascaris suum SOMATIC MUSCLE

ELECTROPHYSIOLOGICAL EFFECTS OF PIPERAZINE AND DIETHYLCARBAMAZINE ON Ascaris suum SOMATIC MUSCLE

Histochemical changes inSetaria cervi caused by certain anthelmintics

Mode of action of common anthelmintics

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