The presence of Chlamydia trachomatis infection in men with chronic prostatitis

Abstract

Introduction The aim of the study was to evaluate the frequency of occurrence of Chlamydia trachomatis (C.t.) DNA in the prostate material in the group of individuals with the chronic prostatitis. Material and methods The study included 65 males aged between 47 and 68 years of age, reporting for transrectal prostate biopsy because of the elevated serum prostate-specific antigen concentration and/or abnormalities detected in prostate palpation per rectum. The urethral smear collection was performed in all the patients in order to detect C.t. DNA. After that, the transrectal prostate biopsy was performed (histopathology tests, C.t. DNA). Additionally, the levels of anti-C.t. IgG antibodies and anti-C.t. IgA antibodies were checked in the serum. The DNA isolation from prostate specimens was conducted with the use of the Chelex method, while the C.t. DNA detection – with the ligase chain reaction. Specific antibodies were detected with the use of the ELISA method. Results C.t. DNA in the prostate gland was found in 7 out of 65 men (10.8%). In urethral smear, C.t. was found in none of the individuals. Anti-C.t. IgA antibodies were detected in the serum of 16/65 (24.6%), while anti-C.t. IgG antibodies in 6/65 (9.2%) of the examined males. IgA antibodies were found in two and IgG in one out of the 7 men who had C.t. infection in the prostate. Conclusions The presence of C.t. DNA in the prostate gland may be indicative of the role of chlamydia in the development of chronic prostatitis.

Chronic Prostatitis: Impact of Lifestyle, Infection, and Inflammation on Semen Parameters

“…In both semen and urine samples, C. trachomatis DNA was detected in both groups (urine: control 24.4% vs. prostatitis 20.7%, p = 0.7078; semen: control 10.9% vs. prostatitis 24.1%, p = 0.1279); although the effect on semen quality reported by Farahani et al [56] was not observed. However, this agent was detected with high frequency when compared to that reported by Bielecki et al, [57], who observed a 10.8% prevalence of C. trachomatis in prostate biopsies from 65 volunteers aged 47-68 years who presented an increase in PSA or abnormal findings on palpation of the prostate in the andrological examination. T. vaginalis was detected more frequently in semen samples from volunteers with chronic prostatitis (4.3% vs. 17.2%, p = 0.0616); this microorganism has been associated with increasing risk of prostate cancer [10], [11].…”

Microbial etiology of bacterial chronic prostatitis: systematic review

“…Otra bacteria atípica cuya implicación en la etiología de la PCB ha generado mucha controversia es Chlamydia trachomatis [29], ya reconocido como un microorganismo claramente causante de esta entidad [9,[30][31][32]. Además, sabemos que el curso sintomático de la PCB causada por este microorganis-faecium (297; 6,83%); en un 5,67% de los casos no se especifica la especie responsable.…”

Antibiotic resistance changes in episodes of symptomatic bacteriospermia: development in a health area of southeast Spain

“…fue el patógeno que con más frecuencia se detectó en pacientes con PCB en el contexto de las consultas de atención primaria, y el segundo si nos referimos al ámbito hospitalario. Otra bacteria atípica cuya implicación en la etiología de la PCB ha sido reconocida es Chlamydia trachomatis [ 13 , 14 ]. Sin embargo, en nuestro estudio solo se han detectado en 8 (2,20%) episodios.…”