The Preparation of Rapidly Disintegrating Tablets in the Mouth

Abstract

Elderly people, children and patients sometimes have difficulties swallowing tablets. To solve this problem, a novel method of preparing tablets that disintegrate rapidly in the mouth was developed. A tablet with high porosity is required for rapid disintegration, but such a tablet is generally fragile. To make a tablet having both high porosity and practical strength, amorphous sucrose, which has good compactability, was used. Mannitol powder with freeze-dried amorphous sucrose was tableted at low compression and stored under certain conditions. The tablet disintegrated rapidly in the mouth, because of its high porosity. The tensile strength of the tablet increased remarkably during storage, while the porosity of the tablet seemed almost unchanged. The results of thermal analysis and powder x-ray diffraction measurement showed that the amorphous sucrose in tablet crystallized during storage. The increase in the tensile strength of the tablet was due to crystallization of the amorphous sucrose and formation of new internal contact points in the tablet. It was concluded that this crystalline transition method is a very useful method to prepare a rapidly disintegrating tablet.

Swallowing Function Improvement Effect of Ginger <i>(Zingiber officinale)</i>

“…water absorption time, and oral disintegration time (Kikoshi et al, 2010;Nishiura, 2008;Sugimoto et al, 2001).…”

Orodispersible dosage forms: biopharmaceutical improvements and regulatory requirements

“…As an example, the granulation of a low compressibility saccharide, such as mannitol 124 which provides fast disintegration, with a high compressibility saccharide, such as maltose, produces strong 125 compacts with high tensile strength and fast disintegration time [15]. And again, when freeze-dried 126 amorphous sucrose mixed with mannitol was compressed at low compression strength, crystallization of 127 the amorphous sucrose in the tablet occurred, increasing the tablet tensile strength without altering the 128 original tablet porosity [13]. Moreover, spray-drying is considered a valuable tool for the development of 129 tableting multifunctional excipients with improved flowability and porosity [12].…”

“…heat or humidity) were also proposed to produce hard tablets without 119 compromising disintegration time [13,14]. However, possible variations on the drug solid state limit the 120 application of these approach [12].…”

Development of a Novel and Simple Method to Evaluate Disintegration of Rapidly Disintegrating Tablets

“…Many studies have recorded disintegration times in the human mouth. 6,7) However, evaluating the disintegration time in the human mouth entails the following problems: 1) the disintegration time in the mouth tends to depend on oral environments and conditions, and thus, results are scattered; and 2) the human sensory test has risks for healthy volunteers. Many other disintegration test methods have been proposed such as a modified disintegration test and a modified dissolution test.…”