The preparation of poly-levodopa coated capillary column for capillary electrochromatography enantioseparation

Guo, Heying; Sun, Yu; Niu, Xiaoying; Wei, Nannan; Pan, Congjie; Wang, Guoxiu; Zhang, Huige; Chen, Hongli; Yi, Tao; Chen, Xingguo

doi:10.1016/j.chroma.2018.10.007

Cited by 21 publications

(8 citation statements)

References 35 publications

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“…The significance of polydopamine was quickly realized resting on its capability to adapt to various surface functions. This behavior was also observed for other catecholamines, such as l ‐3,4‐dihydroxyphenylalanine ( l ‐DOPA) and norepinephrine . Chemically, polycatecholamine films possess important functional groups including amines, alcohols, and conjugated Michael acceptors leading to a massive variety of post‐functionalized surfaces .…”

Section: Introductionmentioning

confidence: 74%

Transferrin‐Coated Nanodiamond–Drug Conjugates for Milliwatt Photothermal Applications

Harvey

Raabe

Ermakova

et al. 2019

Advanced Therapeutics

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Fluorescent nanodiamonds (fNDs) are unique carbon-based nanomaterials due to their outstanding optical and magnetic properties. However, realization of the full potential of fNDs is often limited by their processability because fNDs aggregate strongly in both organic and aqueous solutions. Therefore, robust and potentially universal coating strategies are urgently needed to address these limitations. Derived from mussel foot proteins, the polymerization of l-3,4-dihydroxyphenylalanine (l-DOPA) provides important surface functional groups including amines, carboxylic acid, alcohols, and conjugated Michael acceptors. Herein, l-DOPA is polymerized on fNDs with a high control over the shell thickness. Photoluminescence and optically detected magnetic resonance studies reveal that the unique photophysical properties of fNDs are preserved after thin poly(l-DOPA) film coating. Subsequently, conjugation of transferrin, a heme protein that provides efficient receptor-specific cellular transport, improves the colloidal stability and cellular uptake of the poly(l-DOPA)-coated fNDs. The loading of FDA-approved indocyanine green as a photothermal agent yields an integrated biohybrid material exhibiting an amplified photothermal effect in cells at very low energy intake (≈90 mW cm −2 ).

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Section: Introductionmentioning

confidence: 74%

Transferrin‐Coated Nanodiamond–Drug Conjugates for Milliwatt Photothermal Applications

Harvey

Raabe

Ermakova

et al. 2019

Advanced Therapeutics

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“…In recent years, there were many novel homo‐polymers or copolymers synthesized in order to meet the needs for the separation of different analytes . Liu and co‐workers reported an example of partially filled PLOT capillary column with immobilized pH gradient (PLOT‐IPG) for OT‐CEC analysis of amino acids and proteins.…”

Section: Open‐tubular Capillary Electrochromatographymentioning

confidence: 99%

Recent developments of monolithic and open‐tubular capillary electrochromatography (2017–2019)

Yin

Zhang

et al. 2020

J of Separation Science

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Capillary electrochromatography, which combined the high selectivity of highperformance liquid chromatography and the high separation efficiency of capillary electrophoresis, is an attractive separation tool. In this review, the developments on monolithic and open tubular capillary electrochromatography during 2017 to August 2019 are summarized. Considering the development of novel stationary phases is the most active research field in capillary electrochromatography, monolithic capillary electrochromatography is classified according to the polymer-based and hybrid monolithic columns, while open-tubular capillary electrochromatography is categorized by cyclodextrin, silica, polymer, nanomaterials, microporous materials, and biomaterials-based open tubular columns. K E Y W O R D S

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“…In CEC, just as in every chromatographic system, the column (capillary) is the most critical component. The capillary columns in CEC are usually classified into three main formats: (i) packing for packed‐CEC , (ii) monolithic or continuous rod for monolithic CEC , and (iii) immobilization on the inner walls of the capillary for open tubular CEC (OTCEC) . Compared to packed or monolithic column CEC, the latter has gained increasing attention in pharmaceutical, environmental, clinical, biological, and food analysis .…”

Section: Introductionmentioning

confidence: 99%

Sol‐gel technique for the preparation of β‐cyclodextrin gold nanoparticles as chiral stationary phase in open‐tubular capillary electrochromatography

Jiang

Tian

et al. 2019

J of Separation Science

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A novel open‐tubular capillary electrochromatography column coated with β‐cyclodextrin was prepared using the sol‐gel technique. In the sol‐gel approach, owing to the three‐dimensional network of sol‐gel and the strong chemical bond between the stationary phase and the surface of capillary columns, good chromatographic characteristics and unique selectivity in separating enantiomers were shown. The influences of capillary inner diameter, coating time, organic modifier, buffer pH, and buffer concentration on separation were investigated. The sol‐gel‐coated β‐cyclodextrin column has shown improved enantioseparation efficiency of chlorphenamine, brompheniramine, pheniramine, zopiclone in comparison with the sol‐gel matrix capillary column. The migration time relative standard deviation of the separation of the enantiomers was less than 0.89% over five runs and 2.9% from column to column. This work confirmed that gold nanoparticles are promising electrochromatographic support to enhance the phase ratio of open‐tubular capillary electrochromatography column in capillary electrochromatography.

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The preparation of poly-levodopa coated capillary column for capillary electrochromatography enantioseparation

Cited by 21 publications

References 35 publications

Transferrin‐Coated Nanodiamond–Drug Conjugates for Milliwatt Photothermal Applications

Transferrin‐Coated Nanodiamond–Drug Conjugates for Milliwatt Photothermal Applications

Recent developments of monolithic and open‐tubular capillary electrochromatography (2017–2019)

Sol‐gel technique for the preparation of β‐cyclodextrin gold nanoparticles as chiral stationary phase in open‐tubular capillary electrochromatography

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