Fate and Relationship of N-Methyl to Activity of Morphine 237 This material gelled in most organic solvents, but was recrystallized from about 5 1. of dioxane 3 times and once from 3.5 1. of chloroform to obtain white waxy crystals, m.p. 120-122°. Other close analogs showed the same tendency to gel in most organic solvents at conventional concentrations.Acknowledgments.-We are grateful to Dr. D. B. Seeley for the fermentative preparation of the epoxy-succinic acid, to Dr. S. Y. P'an for measuring hypnotic activities, to Joseph Kaiser for toxicity determinations, to Dr. Arthur English for the antifungal tests, and to Charles Scott for technical assistance. Insecticide tests were done at the Wisconsin Alumni Research Foundation.