The preparation and isomerization of platinum metronidazole complexes: X-ray crystal and molecular structures of cis- and trans-dichlorobis[1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole]-platinum(II)

Metal Complexes as Photo- and Radiosensitizers

“…Pt complexes of metro (286) include cis-Pt(metro) 2 Cl 2 (294), which was obtained by addition of K 2 PtCl 4 to a suspension of 286 in H 2 O at 50 °C (90% yield). Heating of 294 at its melting point (180 °C) or in ethanolic suspension resulted in transformation to trans-Pt(metro) 2 Cl 2 (295) in quantitative yield, a rare example in Pt chemistry 372 (Scheme 53). The molecular structures of 294 and 295 were established by X-ray crystallography, revealing that only the thermodynamically favored trans-isomer was produced.…”

Development and validation of a LC/TOF MS method for the determination of carboplatin and paclitaxel in nanovesicles

“…CPT is a polar, weakly basic molecule that is stable when stored in the dark at room temperature. 8 A number of methods, including high performance liquid chromatography 9 , atomic absorption spectrometry 10 , inductively coupled plasma-mass spectrometry 11 , X-ray 12 and nuclear magnetic resonance 13 , have been used to assay CPT. More recently, a LC/MS method with a sensitivity (LLOQ of 2 ng/mL) approaching that of atomic absorption spectrometry has been developed for the quantification of CPT in human plasma ultrafiltrates.…”

Multinuclear MR studies of Platinum(II) nitroimidazole complexes: 15N‐labelling and reactions with nucleotides

“…25 Further support for N-7 coordination of 5'-GMP was provided by the pH titration behaviour of the H-8 peak : inflections were observed corresponding to the deprotonation of the 5'-phosphate and N-1 protons for both the free ligand and the complex, but only 5'-GMP showed deprotonation of N-7 at low pD (2)(3)(4). Little change in the value of J(H-l', H-2') on platination of the purine base was observed, and therefore, in contrast to the analogous ammine complex, little change in the sugar ring conformation from 'S' towards 'N' (C-3'-endo) appears to occur in [Pt(MNZ),(5'-GMP),12'.…”