The Premacular Bursa's Shape Revealed In Vivo by Swept-Source Optical Coherence Tomography

Schaal, Karen B.; Pang, Claudine E.; Pozzoni, María Carolina; Engelbert, Michael

doi:10.1016/j.ophtha.2013.11.030

Cited by 58 publications

(60 citation statements)

References 11 publications

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“…However, even with extended imaging protocols and en face imaging, SS OCT was still unable to detect the entire superior border of the PPVP in vast majority of subjects and the communication between PPVP with the anterior chamber is not yet fully understood. [16][17][18] SS OCT demonstrated that the size of PPVP increases with increasing severity of myopia. 15 Larger PPVP reflects earlier vitreous liquefaction in high myopia, which may predispose partial and subsequently complete posterior vitreous detachment (PVD).…”

Section: Assessment Of Vitreous By Oct In Myopiamentioning

confidence: 95%

Advances of optical coherence tomography in myopia and pathologic myopia

Cheung

Luk

et al. 2016

Eye

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Section: Assessment Of Vitreous By Oct In Myopiamentioning

confidence: 95%

Advances of optical coherence tomography in myopia and pathologic myopia

Cheung

Luk

et al. 2016

Eye

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“…The premacular bursa is a fluid filled cavity inside the vitreous body that could be communicating via the space of Martegiani and Cloquets canal to the retrolenticular space. 25 As diffusion and convection within these fluid-filled cavities will be much faster than in a gel-like vitreous, active molecules will be diluted and the concentration gradient to diffuse through the posterior vitreous cortex to reach the vitreoretinal interface will decrease. Taking the case of a product with a short half-life, this could explain the difference between a successful treatment or otherwise.…”

Section: Discussionmentioning

confidence: 99%

Intravitreally Injected Fluid Dispersion: Importance of Injection Technique

Willekens

Reyns²,

Diricx³

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. The purpose of this study was to evaluate the dispersion of intravitreally injected solutions and investigate the influence of varying injection techniques.METHODS. This was a prospective study using enucleated porcine eyes and ultra-highresolution computed tomography (UHRCT) scanning to visualize iomeprol intravitreal dispersion. Sixty eyes were divided over 12 different groups according to the injection procedure: fast (2 seconds) or slow (10 seconds) injection speed and needle tip location (6-and 12-mm needle shaft insertion or premacular tip placement verified by indirect ophthalmoscopy). For each of these combinations, eyes were either injected with the combination of V20I (which is an analogue of ocriplasmin) and iomeprol or iomeprol alone. Distance to the macula and volume measurements were performed at 1, 2, 3, and 5 hours after injection.RESULTS. The measured contrast bolus volume increases slowly over time to an average of 0.70 (P ¼ 0.03), 1.04 (P ¼ 0.006), and 0.79 (P ¼ 0.0001) cm 3 5 hours after the injection for the 6-mm needle shaft insertion, 12-mm needle shaft insertion, and premacular needle tip placement, respectively. The distance to the macular marker was significantly lower for premacular needle tip placement injections compared with 6-and 12-mm needle shaft insertion depths.CONCLUSIONS. Ultra-high-resolution computed tomography with three-dimensional reconstruction offers the possibility to study the dispersion of intravitreally injected solutions in a noninvasive manner. Intravitreal premacular solution delivery is possible with an indirect ophthalmoscope-guided injection technique and significantly reduces the time to reach the posterior pole in respect to 6-and 12-mm needle insertion depths. The speed of injection does not influence dispersion significantly.

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“…The premacular thin vitreous cortex is the posterior wall of the PPVP. Its anterior wall is formed by the vitreous gel [20][21][22][23][24][25][26]. It has been demonstrated that PPVP plays role in some VRI disorders including idiopathic ERM, DME, PDVR, foveal cyst and MH.…”

Section: Posterior Precortical Vitreous Pocket (Ppvp)mentioning

confidence: 99%

“…It has been demonstrated that PPVP plays role in some VRI disorders including idiopathic ERM, DME, PDVR, foveal cyst and MH. These pathologies may be explained by the posterior wall of the PPVP acting as an ERM on the macula or the residual premacular vitreous cortex causing trampoline-like traction on the perifovea [20][21][22][23][24][25][26].…”

Section: Posterior Precortical Vitreous Pocket (Ppvp)mentioning

confidence: 99%

The Time to Focus on the Imaging of Posterior Vitreous and Vitreoretinal Interface by Optical Coherence Tomography

Turgut¹

2017

AOVS

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Vitreous humor plays important role in ocular in growth, the maintaining of ocular media transparency and tonus. It is difficult to exactly assess the relationship between the vitreous and the macula with only slit lamp bio microscopy. Spectral domain optical coherence tomography provides to evaluate the vitreomacular interface and posterior vitreous. Some vitreomacular interface diseases or the risk factors for these can be demonstrated the imaging of posterior vitreous by optical coherence tomography.

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The Premacular Bursa's Shape Revealed In Vivo by Swept-Source Optical Coherence Tomography

Cited by 58 publications

References 11 publications

Advances of optical coherence tomography in myopia and pathologic myopia

Advances of optical coherence tomography in myopia and pathologic myopia

Intravitreally Injected Fluid Dispersion: Importance of Injection Technique

The Time to Focus on the Imaging of Posterior Vitreous and Vitreoretinal Interface by Optical Coherence Tomography

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