The predictive value of uterine blood flow in detecting the risk of adverse pregnancy outcome in patients with polycystic ovary syndrome

Nouh, Amal; Shalaby, Sally M.

doi:10.1016/j.mefs.2011.09.001

Cited by 8 publications

(13 citation statements)

References 23 publications

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“…However, Wang et al reported IUGR to be more prevalent in women with PCOS compared to controls of similar age and BMI. Meta‐analyses have also reported similar risks for small for gestational age (SGA) birth among infants born to mothers with and without PCOS although discrepant results in individual studies are noted . The risk of large for gestational age (LGA) birth does not seem to change significantly by PCOS status .…”

Section: Pcos and Adverse Pregnancy Outcomes: Studies And Limitationsmentioning

confidence: 97%

“…However, a study by Bjercke et al on singleton pregnancies among 23 IR and 29 non‐IR women with PCOS and 355 controls reported no differences in GDM in the IR women with PCOS compared to both non‐IR women with PCOS and controls . Higher risk for GDM has been reported among normal and overweight women with PCOS in association with elevated higher baseline insulin levels compared to their age‐ and BMI‐matched controls …”

Section: Possible Contributing Mechanisms Of Pcos In Adverse Pregnancmentioning

confidence: 98%

“…However, overall, meta‐analyses to date report that compared to women without PCOS, women with PCOS are at significantly higher risk for GDM (ranging from 2.8‐3.7) . Age‐ and BMI‐matched studies have shown an independent higher risk of GDM in normal and overweight women with PCOS, but the risk in obese women (BMI > 30 kg/m 2 ) with and without PCOS is similar . In countries with universal screening, the same protocol is used for women with and without PCOS.…”

Section: Pcos and Adverse Pregnancy Outcomes: Studies And Limitationsmentioning

confidence: 99%

“…Meta-analyses have also reported similar risks for small for gestational age (SGA) birth among infants born to mothers with and without PCOS 13,16 although discrepant results in individual studies are noted. 25,26 The risk of large for gestational age (LGA) birth does not seem to change significantly by PCOS status. 27,36 Given the underlying effect of hyperinsulinemia and obesity in the pathophysiology of the PCOS 11 and higher risk of GDM among women with PCOS, 16…”

Section: Foetal and Infant Complicationsmentioning

confidence: 99%

“…39 Higher risk for GDM has been reported among normal and overweight women with PCOS in association with elevated higher baseline insulin levels compared to their age-and BMI-matched controls. 25,26 Insulin has been shown to have both direct and indirect effect on vessels leading to vasoconstriction and HDP. 45 Insulin also promotes prothrombotic and profibrotic effects through provocation of various growth factors.…”

Section: Contributing Effect Of Ir In Adverse Pregnancy Outcomesmentioning

confidence: 99%

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Polycystic ovary syndrome and adverse pregnancy outcomes: Current state of knowledge, challenges and potential implications for practice

Khomami

Boyle

Tay

et al. 2018

Clinical Endocrinology

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Summary Although there is a growing body of literature reporting that pregnancies in women with polycystic ovary syndrome (PCOS) are associated with greater complications than those without PCOS, methodological differences across studies make these results difficult to consolidate. This narrative review outlines potential mechanisms involved in adverse pregnancy outcomes in PCOS and the nature of the complications. It covers limitations of current evidence and future research directions. Future research should include prospective studies with phenotypic stratification of PCOS and matching or consideration of specific PCOS manifestations and risk factors specific to each pregnancy complication. This review also emphasizes the importance of following a healthy lifestyle for women with PCOS and of individualized care according to overall risk factors for pregnancy complications.

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Section: Pcos and Adverse Pregnancy Outcomes: Studies And Limitationsmentioning

confidence: 97%

Section: Possible Contributing Mechanisms Of Pcos In Adverse Pregnancmentioning

confidence: 98%

Section: Pcos and Adverse Pregnancy Outcomes: Studies And Limitationsmentioning

confidence: 99%

Section: Foetal and Infant Complicationsmentioning

confidence: 99%

Section: Contributing Effect Of Ir In Adverse Pregnancy Outcomesmentioning

confidence: 99%

See 3 more Smart Citations

Polycystic ovary syndrome and adverse pregnancy outcomes: Current state of knowledge, challenges and potential implications for practice

Khomami

Boyle

Tay

et al. 2018

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

Management of associated risks of pregnancy in polycystic ovary syndrome

Sheikh¹,

Islam²,

Najmi³

2024

Polycystic Ovary Syndrome

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Systematic review and meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome

Bahri Khomami,

Shorakae,

Hashemi

et al. 2024

Nat Commun

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Screening for polycystic ovary syndrome (PCOS) in antenatal care is inadequate, largely owing to the lack of clarity around whether PCOS is an independent risk factor for pregnancy complications. This systematic review and meta-analysis include 104 studies and 106,690 pregnancies in women with and without PCOS from inception until 13th July 2022. We report that women with PCOS are younger and have higher body mass index (BMI) around conception and have greater gestational weight gain. The odds of miscarriage, gestational diabetes mellitus, gestational hypertension, pre-eclampsia and cesarean section are higher in women with PCOS. The increased odds of adverse outcomes in PCOS remain significant when age and BMI are matched and when analyses are restricted to high-quality studies. This work informed the recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome, emphasizing that PCOS status should be captured in all women who are planning to, or have recently become pregnant to facilitate prevention of adverse outcomes and improve pregnancy outcomes.

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The predictive value of uterine blood flow in detecting the risk of adverse pregnancy outcome in patients with polycystic ovary syndrome

Cited by 8 publications

References 23 publications

Polycystic ovary syndrome and adverse pregnancy outcomes: Current state of knowledge, challenges and potential implications for practice

Polycystic ovary syndrome and adverse pregnancy outcomes: Current state of knowledge, challenges and potential implications for practice

Management of associated risks of pregnancy in polycystic ovary syndrome

Systematic review and meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome

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