The predictive value of psoas and paraspinal muscle parameters measured on MRI for severe cage subsidence after standalone lateral lumbar interbody fusion

Moser, Manuel; Amini, Dominik Adl; Jones, Conor; Zhu, Jiaqi; Okano, Ichiro; Oezel, Lisa; Chiapparelli, Erika; Tan, Ek Tsoon; Shue, Jennifer; Sama, Andrew A.; Cammisa, Frank P.; Girardi, Federico P.; Hughes, Alexander P.

doi:10.1016/j.spinee.2022.03.009

Cited by 18 publications

(11 citation statements)

References 42 publications

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“…The unique strength of our study is the clinically relevant and large patient population undergoing spinal fusion surgery, with a focus on bone collagen properties by multiphoton microscopy, the use of the more reliable measure of bone density with QCT, and an extensive workup with metabolic bone and health status in a prospective setting. Given that lumbar fusion is one of the most common surgeries in the United States and that bone quality and muscle properties are considered risk factors for instrumentation failure and cage subsidence, it is particularly important to improve our understanding of muscle-bone interactions in the spine 25,56 . Sarcopenia and osteoporosis, despite their high prevalence in spinal surgery populations, are not yet adequately addressed by the surgical specialties 30,57,58 .…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, the right and left sides of the associated muscles were summarized and normalized by the patients’ height (cm 2 /m 2 ), to account for the potential confounding effect of height. The measurement method with the ITK SNAP segmentation program previously demonstrated good to excellent intra- and inter-rater reliability 24,25 …”

Section: Methodsmentioning

confidence: 99%

“…The measurement method with the ITK SNAP segmentation program previously demonstrated good to excellent intra-and interrater reliability. 24,25 Quantitative Computed Tomography (QCT)…”

Section: Mri-based Cross-sectional Muscle Measurementmentioning

confidence: 99%

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Osteosarcopenia in the Spine Beyond Bone Mineral Density

Haffer

Muellner

Chiapparelli

et al. 2023

Spine

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Osteosarcopenia in the Spine Beyond Bone Mineral Density

Haffer

Muellner

Chiapparelli

et al. 2023

Spine

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“…Cage subsidence is an important complication of OLIF surgery, which is closely related to the patient’s prognosis [ 21 ]. Reasonable selection of the size of the cage can reduce the probability of cage subsidence and achieve better bone graft fusion effect.…”

Section: Discussionmentioning

confidence: 99%

Anatomical characteristics affecting the surgical approach of oblique lateral lumbar interbody fusion: an MR-based observational study

Han

et al. 2022

J Orthop Surg Res

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Background Oblique lateral lumbar interbody fusion (OLIF) is one of the most widely used lumbar interbody fusion procedures in clinical practice. The aim of this study was to minimize the incidence rate of surgical complications by measuring the anatomical parameters of structures surrounding the working channels of OLIF with 3D COSMIC sequence. Methods The MRI examination included conventional MRI sequence and 3D COSMIC sequence. Surgical window, psoas thickness, the transverse diameter of the endplate, and nerve distance were measured to evaluate the anatomical characteristics surrounding the OLIF working channels. Results The widths of the natural surgical window at the level of the L2–3, L3–4, and L4–5 intervertebral measured in this study were 16.25 ± 4.22, 15.46 ± 4.64 mm, and 11.71 ± 6.29 mm, respectively. The average thickness of the left psoas major muscle at the level of L2–3, L3–4, and L4–5 intervertebral space was 28.42 ± 5.08 mm, 30.76 ± 5.84 mm, and 31.16 ± 7.72 mm, respectively. The mean value of insertion angle (β) was 45.57° ± 6.19° in L2–3 intervertebral space, 49.90° ± 6.53° in L3–4 intervertebral space, and 43.34° ± 8.88° in L4–5 intervertebral space. Conclusions The 3D COSMIC sequences can be used for imaging anatomical assessment before OLIF surgery. In preoperative planning, the 3D COSMIC sequence can be used to measure the relevant parameters mentioned above to optimize the planned surgical approach.

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“…The number of lumbar fusions chosen for IVDD, IVD herniation, and spinal stenosis in the United States accounted for 42.3% of the total number of this procedure in 2015 ( Martin et al, 2019 ). Overall, spinal fusion has become the first choice for patients with IVDD, but complications such as slow postoperative recovery, infection, LBP recurrence, fusion failure, cage subsidence, and adjacent segmental disease also pose significant problems for patients and clinicians ( Eliasberg et al, 2016 ; Moser et al, 2022 ; Zhang N.-Z. et al, 2022 ).…”

Section: Mechanisms and Treatment Strategies Of Ivddmentioning

confidence: 99%

New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System

Guo

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Intervertebral disc (IVD) degeneration (IVDD) has been considered the dominant factor in low back pain (LBP), and its etiological mechanisms are complex and not yet fully elucidated. To date, the treatment of IVDD has mainly focused on relieving clinical symptoms and cannot fundamentally solve the problem. Recently, a novel microsphere-based therapeutic strategy has held promise for IVD regeneration and has yielded encouraging results with in vitro experiments and animal models. With excellent injectability, biocompatibility, and biodegradability, this microsphere carrier allows for targeted delivery and controlled release of drugs, gene regulatory sequences, and other bioactive substances and supports cell implantation and directed differentiation, aiming to improve the disease state of IVD at the source. This review discusses the possible mechanisms of IVDD and the limitations of current therapies, focusing on the application of microsphere delivery systems in IVDD, including targeted delivery of active substances and drugs, cellular therapy, and gene therapy, and attempts to provide a new understanding for the treatment of IVDD.

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The predictive value of psoas and paraspinal muscle parameters measured on MRI for severe cage subsidence after standalone lateral lumbar interbody fusion

Cited by 18 publications

References 42 publications

Osteosarcopenia in the Spine Beyond Bone Mineral Density

Osteosarcopenia in the Spine Beyond Bone Mineral Density

Anatomical characteristics affecting the surgical approach of oblique lateral lumbar interbody fusion: an MR-based observational study

New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System

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