The Predictive Value of IgE as Biomarker in Asthma

Obaidi, Amina Hamed Ahmad Al; Samarai, Abdul Ghani Mohamed Al; Samarai, Abdul Kareem Yahya Al; Janabi, Jasim Mohamad Al

doi:10.1080/02770900802126958

Cited by 51 publications

(24 citation statements)

References 54 publications

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“…IgE is also one among the main factors constituting with FcεR I on the surfaces of the mast cells causing release of chemokines and cytokines by degranulation, resulting in severe asthmatic condition (Calabrese, Triggiani, Marone, & Mazzarella, ; Galli et al, ). Elevated levels of IgE (tenfolds) were reported in the blood of asthma patients when compared with normal healthy adult, indicating the significant presence of IgE during asthmatic conditions (Ahmad Al Obaidi, Mohamed Al Samarai, Yahya Al Samarai, & Al Janabi, ; Sandeep et al, ). However, the true factor for the involvement of IgE in causing asthma remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma

Zhang

Wang

et al. 2018

Drug Development Research

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Asthma is termed as the induction of chronic inflammation in the airway lumen of lungs due to accumulation of inflammatory cells which affects normal breathing process. Prolonged accumulation of inflammatory cells leads to oxidative stress and suppression of antioxidant activities. Therefore, in our present investigation, a potential phenolic compound, Syringic acid was tested for the suppression of inflammatory markers toward an antiasthmatic activity in ovalbumin (OVA)‐induced asthmatic mice model. As a result, the Syringic acid treatment was found to suppress the inflammatory cells; eosinophil, neutrophil, macrophage, lymphocyte, and other inflammatory markers including IL‐4, IL‐5, IL‐13, and TNF‐α in the BALF of OVA‐induced asthmatic mice. Similarly, IgE levels were significantly reduced in the blood serum of Syringic acid treated mice groups. In this context, the IFN‐γ levels were found enhanced in the BALF of Syringic acid treated asthmatic mice groups, expressing an anti‐inflammatory response. Enzymatic and nonenzymatic antioxidants such as SOD, CAT, and GSH levels were found high in the Syringic acid treatment than the asthmatic control group, which depicts the antioxidant response of Syringic acid on asthmatic groups. Intriguingly, the ROS, NO2, NO3, and MDA levels were inhibited in the BALF of Syringic acid treated mice groups. The airway hyper‐reactivity (AHR) was comparatively normal in the Syringic acid treatment as it was severe in the case of asthmatic control group. Consequently, the effect of Syringic acid is prominent in the treatment of asthma by controlling the accumulation of inflammatory cells, other inflammatory markers along with enhancement of antioxidant markers, suppression of ROS and controlling airway hyperreactivity. Hence, Syringic acid may be recommended for clinical trials in the treatment of asthma.

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Section: Discussionmentioning

confidence: 99%

Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma

Zhang

Wang

et al. 2018

Drug Development Research

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“…We included in our analysis proportion of Native American ancestry (ranging from 0 to 1) for Study A (20), proportion of African ancestry (ranging from 0 to 1) (19), body mass index (BMI) category (22), socioeconomic status (23), total immunoglobulin E (IgE) levels (24,25), family history of asthma (26), chest illnesses before age 2 (27), maternal prenatal smoking (28), birth weight (28,29), recruitment center (representative of geographic location) (30) and sex (21). …”

Section: Methodsmentioning

confidence: 99%

Breastfeeding associated with higher lung function in African American youths with asthma

Zeiger

et al. 2017

Journal of Asthma

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Objective In the United States, Puerto Ricans and African Americans have lower prevalence of breastfeeding and worse clinical outcomes for asthma compared with other racial/ethnic groups. We hypothesize that history of breastfeeding is associated with increased forced expiratory volume in 1 second (FEV1) % predicted and reduced asthma exacerbations in Latino and African American youths with asthma. Methods As part of Study A and Study B, we conducted case-only analyses in children and adolescents aged 8–21 years old with asthma from four different racial/ethnic groups: African Americans (n=426), Mexican Americans (n=424), mixed/other Latinos (n=255), and Puerto Ricans (n=629). We investigated the association between any breastfeeding in infancy and FEV1 % predicted as well as asthma exacerbations using multivariable linear and Poisson regression models, respectively. Results Prevalence of breastfeeding was lower in African Americans (59.4%) and Puerto Ricans (54.9%) compared to Mexican Americans (76.2%) and mixed/other Latinos (66.9%; p<0.001). After adjusting for covariates, breastfeeding was associated with a 3.58 percentage point increase in FEV1 % predicted (p = 0.01) and a 21% reduction in asthma exacerbations (p = 0.03) in African Americans only. Conclusion Breastfeeding was associated with higher FEV1 % predicted in asthma and reduced number of asthma exacerbations in African American youths, calling attention for continued support for breastfeeding

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“…However, only a subset of allergic patients develops asthma and, in contrast, substantial numbers of nonatopic subjects have asthma. Conversely, some authors reported an inverse association between serum IgE and FEV1 values in asthma [138], possibly in relation to the increased severity of nonatopic asthma. Although the importance of IgE for clinicians taking care of asthmatics had progressively declined, the arrival of anti-IgE therapy reversed this trend after the demonstration of its efficacy in allergic asthma, including at the severe side of the spectrum [1].…”

Section: Ige As a Therapeutic Target And A Biomarker In Asthmamentioning

confidence: 99%

Asthma phenotypes and IgE responses

et al. 2015

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The discovery of IgE represented a major breakthrough in allergy and asthma research, whereas the clinical interest given to IgE in asthma has been blurred until the arrival of anti-IgE biotherapy. Novel facets of the complex link between IgE and asthma have been highlighted by the effect of this treatment and by basic research. In parallel, asthma phenotyping recently evolved to the concept of endotypes, relying on identified/suspected pathobiological mechanisms to phenotype patients, but has not yet clearly positioned IgE among biomarkers of asthma.In this review, we first summarise recent knowledge about the regulation of IgE production and its main receptor, FcεRI. In addition to allergens acting as classical IgE inducers, viral infections as well as air pollution may trigger the IgE pathway, notably resetting the threshold of IgE sensitivity by regulating FcεRI expression. We then analyse the place of IgE in different asthma endo/phenotypes and discuss the potential interest of IgE among biomarkers in asthma. @ERSpublications We summarise regulation of IgE production, and discuss IgE in different asthma endo/ phenotypes and among biomarkers

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The Predictive Value of IgE as Biomarker in Asthma

Abstract: Serum IgE level was predictive in asthma, and it may be used to differentiate between asthmatic and non-asthmatic individuals in conjunction with other biomarkers. Specific immunotherapy reduced serum total IgE level in 36% of patients with asthma.

Cited by 51 publications

References 54 publications

Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma

Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma

Breastfeeding associated with higher lung function in African American youths with asthma

Asthma phenotypes and IgE responses

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