Asthma phenotypes and IgE responses

Froidure, Antoine; Mouthuy, Jonathan; Durham, Stephen R.; Chanez, Pascal; Sibille, Yves; Pilette, Charles

doi:10.1183/13993003.01824-2014

Cited by 220 publications

(191 citation statements)

References 158 publications

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“…In addition, allergen-mediated cross-linking of IgE antibodies bound to the high affinity IgE receptor (FcεRI) may cause the activation and degranulation of pulmonary mast cells, leading to the IgE-dependent early airway response in asthma [31]. It has been reported that airway contraction is caused by the release of various mediators, and higher IgE production is more conducive to mast cell degranulation and airway contraction [32].…”

Section: Discussionmentioning

confidence: 99%

miR-146a Mimics Attenuate Allergic Airway Inflammation by Impacted Group 2 Innate Lymphoid Cells in an Ovalbumin-Induced Asthma Mouse Model

Han¹,

Ma²,

Bao³

et al. 2018

Int Arch Allergy Immunol

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Background: The prevalence of allergic asthma has increased dramatically. Previous studies have found that the microRNA 146a (miR-146a) expression in asthma inhibits cell proliferation and promotes apoptosis of bronchial smooth muscle cells. We aimed to investigate the effect of miR-146a mimics on ovalbumin (OVA)-induced asthma in a mouse model. Methods: Inflammatory cell infiltration in bronchoalveolar lavage fluid (BALF) was measured by flow cytometry. Levels of OVA-specific immunoglobulin E (IgE) in serum and cytokines in BALF were examined by enzyme-linked immunosorbent assay. For monitoring the airway, the Penh value (% baseline) was measured using a whole-body plethysmograph. Results: In OVA-induced asthmatic mice, miR-146a significantly suppressed the infiltration of inflammatory cells in BALF and decreased the levels of OVA-specific IgE and T helper 2 cell type cytokines. In addition, miR-146a inhibited the OVA-induced airway hyperresponsiveness and the group 2 innate lymphoid cell responses. Moreover, the effects of miR-146a mimics were dependent on interleukin 33 stimulation. Conclusions: Our results suggest that miR-146a mimics might serve as an attractive candidate for further preclinical studies as an anti-inflammatory treatment of asthma.

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Section: Discussionmentioning

confidence: 99%

miR-146a Mimics Attenuate Allergic Airway Inflammation by Impacted Group 2 Innate Lymphoid Cells in an Ovalbumin-Induced Asthma Mouse Model

Han¹,

Ma²,

Bao³

et al. 2018

Int Arch Allergy Immunol

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“…IgE has an essential role in allergic asthma [47]. Allergic patients produce IgE antibodies specific for antigens such as house dust mite and pollens, which bind to IgE-specific receptors on mast cells and basophils.…”

Section: Total Igementioning

confidence: 99%

Improving the diagnosis of eosinophilic asthma

Coumou

Bel

2016

Expert Review of Respiratory Medicine

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“…Most cases of asthma are associated with atopy (defined as the production of specific immunoglobulin (Ig)E in response to common environmental allergens), and this association has led asthma to be regarded largely as an allergic disorder along with other atopic diseases. In fact, the phenotype of childhood-onset atopic asthma is solid and early sensitization is associated in some cases with severe asthma in adulthood [4]. Moreover, atopy is a prevalent feature of all the phenotypes of adult asthma, reaching a prevalence rate of 85% in high-atopy prevalence phenotypes and 66% in low-atopy prevalence ones [5].…”

Section: Introductionmentioning

confidence: 99%

Specific allergen immunotherapy for the treatment of allergic asthma: a review of current evidence

Domínguez‐Ortega

Delgado

Blanco

et al. 2017

J Investig Allergol Clin Immunol

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Asthma is frequently associated with atopy, characterized by the production of specific immunoglobulin E in response to environmental allergens. Currently, two types of allergen immunotherapy (AIT) are used in clinical practice: subcutaneous and sublingual immunotherapy, both accepted as key components of the therapeutic repertoire for allergic rhinitis and conjunctivitis. However, their role in asthma remains controversial. The present document is aimed at providing the clinicians with a review of the evidence on the use of AIT in asthma, focusing on the most relevant aspects of its mechanism of action, its efficacy, and existing data on safety, tolerability, and cost-effectivity, both in pediatric and adult populations. A systematic search of MEDLINE, Cochrane, and Clinical Trials databases from 2000 to April of 2016 was carried out by a panel of experts from the Spanish Allergy and Clinical Immunology Scientific Society. Relevant studies prior to the year 2000 included in ulterior systematic reviews were also considered. More than 4000 articles were identified during the search and 241 were selected to retrieve available evidence on AIT, which was graded according to the Oxford classification. All the group members reviewed the resulting text until the final version reached the consensual agreement. A summary of recommendations on the more relevant topics are proposed. The role of AIT as a valuable therapeutic strategy for prevention of exacerbation and progressive decline in lung function is highlighted. Future research should include specific tools for asthma evaluation when assessing AIT effectiveness in asthmatic patients. ResumenEl asma se asocia frecuentemente con alergia, entendida ésta como la producción de IgE específica frente a alérgenos ambientales. Actualmente, existen dos tipos de inmunoterapia específica con alérgenos (ITE) para la práctica clínica habitual: subcutánea y sublingual, ambas indicadas en el tratamiento de la rinitis y la conjuntivitis alérgicas. Sin embargo, su papel en el asma resulta todavía controvertido. Dominguez-Ortega J, et al.

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Asthma phenotypes and IgE responses

Cited by 220 publications

References 158 publications

miR-146a Mimics Attenuate Allergic Airway Inflammation by Impacted Group 2 Innate Lymphoid Cells in an Ovalbumin-Induced Asthma Mouse Model

miR-146a Mimics Attenuate Allergic Airway Inflammation by Impacted Group 2 Innate Lymphoid Cells in an Ovalbumin-Induced Asthma Mouse Model

Improving the diagnosis of eosinophilic asthma

Specific allergen immunotherapy for the treatment of allergic asthma: a review of current evidence

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