The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome

Agouridakis, Panagiotis; Kyriakou, Despina; Alexandrakis, Michael G.; Prekates, A.; Perisinakis, Kostas; Karkavitsas, Nikolaos; Bouros, Demosthenes

doi:10.1186/rr193

Cited by 89 publications

(62 citation statements)

References 35 publications

(36 reference statements)

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“…NF-kB activation typically involves the phosphorylation of IkB by the IkB kinase (IKK) complex, which results in the degradation of IkB, and subsequent release of NF-kB, allowing it to translocate freely to the nucleus. Upon exposure to LPS, activated NF-kB can release numerous cytokines, including TNF-a, IL-6 and IL-1b, which play a critical role in the generation of ALI (Agouridakis et al, 2002;Bhatia & Moochhala, 2004).…”

Section: Introductionmentioning

confidence: 99%

Protective effects and mechanisms of mogroside V on LPS-induced acute lung injury in mice

Shi

Zheng

Wang

et al. 2014

Pharmaceutical Biology

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Protective effects and mechanisms of mogroside V on LPS-induced acute lung injury in mice, Pharmaceutical Biology, 52:6, 729-734, DOI: 10.3109/13880209.2013 Materials and methods:Female BALB/c mice were treated with commercial mogroside V (2.5, 5 and 10 mg/kg) for 1 h prior to intranasal injection of LPS (10 mg in 50 ml). After 12 h, airway inflammation in the ALI model was determined by the wet/dry weight (W/D) ratio, myeloperoxidase (MPO) activity of lung tissue, leukocyte recruitment and cytokine levels in the bronchoalveolar lavage fluid (BALF). Additionally, lung tissue was examined by histology and western blotting to investigate the changes in pathology and the signalling in the presence and absence of mogroside V. Results: Mogroside V at 5 and 10 mg/kg inhibited airway inflammation induced by LPS as measured by the decrease in the histological changes (44 and 67.3% reduction in lung injury score, respectively), a 28.9 and 55.3% reduction in lung MPO activity, and inflammatory cell counts, interleukin-1b (IL-1b, 382 and 280 pg/ml, respectively), IL-6 (378 and 232 pg/ml, respectively) and tumor necrosis factor-a (TNF-a, 12.5 and 7.8 ng/ml, respectively) levels in the BALF. Additionally, mogroside V treatment reduced the activation of cyclooxygenase 2 (COX-2), inducible NO synthase (iNOS), and the nuclear factor (NF)-kB. Discussions and conclusions: Together, these data suggest that mogroside V has the potential to protect against LPS-induced airway inflammation in a model of ALI.

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Section: Introductionmentioning

confidence: 99%

Protective effects and mechanisms of mogroside V on LPS-induced acute lung injury in mice

Shi

Zheng

Wang

et al. 2014

Pharmaceutical Biology

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“…[48][49][50][51] Interestingly, the development of ARDS can be predicted by the levels of sVCAM-1 in the serum, much like cardiovascular disease. 52 Therefore, it is likely that treatment with PTX will not only decrease the severity of cardiovascular risk in HIV patients but may also reduce the risk of pulmonary disorders.…”

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confidence: 99%

Pentoxifylline Reduces Tumor Necrosis Factor-α and HIV-Induced Vascular Endothelial Activation

Green

Kim

Gupta

et al. 2012

AIDS Research and Human Retroviruses

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Untreated HIV infection is associated with endothelial dysfunction and subsequent cardiovascular disease, likely due to both direct effects of the virus and to indirect effects of systemic inflammation on the vasculature. We have recently shown that treatment with the antiinflammatory agent pentoxifylline (PTX) improved in vivo endothelial function and reduced circulating levels of the inflammatory markers vascular cell adhesion molecule-1 (VCAM-1) and interferon-gamma-induced protein (IP-10) in HIV-infected patients. To delineate the mechanisms underlying this therapeutic effect, we tested whether clinically relevant concentrations of PTX suppress VCAM-1 or IP-10 release in cultivated human lung microvascular endothelial cells. Indeed, we found that tumor necrosis factor (TNF)-a-induced VCAM-1 was reduced with concentrations of PTX in the low nanomolar range, comparable to plasma levels in PTX-treated groups. We also investigated the effect of HIV proteins and found that HIV transactivator of transcription (HIV-Tat) and HIV-envelope-derived recombinant gp120 enhanced TNF-a-induced VCAM-1 gene expression in lung microvascular and coronary macrovascular endothelial cells, respectively. In addition, PTX and a NF-jB-specific inhibitor reduced this enhanced VCAM-1 gene induction in microvascular and macrovascular endothelial cells. These results provide novel insights in how the antiinflammatory agent PTX can directly reduce HIV-associated proinflammatory endothelial activation, which may underlie vascular dysfunction and coronary vascular diseases.

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“…Other soluble fragments of adhesion molecules, such as sP-and sE-selectin, or soluble intercellular adhesion molecule-1, in plasma and bronchoalveolar lavage fluid have been suggested as predictors for the onset and outcome of inflammatory pulmonary complications as well (42,48,53,54 ), and combining these tests may increase the discriminatory power of a prognostic model. However, collecting almost complete information by systematically exploring a broad range of data sources needs to narrow the molecule of interest.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of an Early Soluble L-Selectin (sCD62L) Assay for Risk Assessment in Blunt Multiple Trauma: A Metaanalysis

et al. 2005

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Background: After severe trauma, decreased plasma concentrations of the soluble adhesion molecule Lselectin (sCD62L) have been linked to an increased incidence of lung failure and multiorgan dysfunction syndrome (MODS). Individual studies have had conflicting results, however. We examined multiple studies in an attempt to determine whether early sCD62L concentrations are predictive of major complications after severe trauma. Methods: We performed a systematic review of six electronic databases and a manual search for clinical studies comparing outcomes of multiply injured patients (Injury Severity Score >16) depending on their early sCD62L blood concentrations. Because of various outcome definitions, acute lung injury (ALI) and adult respiratory distress syndrome (ARDS) were studied as a composite endpoint. Weighted mean differences (WMDs) in sCD62L concentrations were calculated between individuals with and without complications by fixed-and random-effects models. Results: Altogether, 3370 citations were identified. Seven prospective studies including 350 patients were eligible for data synthesis. Published data showed the discriminatory features of sCD62L but did not allow for

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The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome

Cited by 89 publications

References 35 publications

Protective effects and mechanisms of mogroside V on LPS-induced acute lung injury in mice

Protective effects and mechanisms of mogroside V on LPS-induced acute lung injury in mice

Pentoxifylline Reduces Tumor Necrosis Factor-α and HIV-Induced Vascular Endothelial Activation

Prognostic Value of an Early Soluble L-Selectin (sCD62L) Assay for Risk Assessment in Blunt Multiple Trauma: A Metaanalysis

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