The predictive potential of hyponatremia for glioblastoma patient survival

Mrowczynski, Oliver; Bourcier, Alexandre J.; Liao, Jason; Langan, Sara; Specht, Charles S.; Rizk, Elias

doi:10.1007/s11060-018-2774-z

Cited by 6 publications

(4 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One recent study analyzed the predictive value of hyponatremia in 200 GBM patients. Similar to the results of this study, the authors could not demonstrate an association between hyponatremia and patients' outcome (22). In this cohort of GBM patients, arterial hypertension, diabetes, a higher age, and a poor preoperative clinical status characterized the cohort of patients with hypochloremia.…”

Section: Discussionsupporting

confidence: 85%

Electrolyte and Renal Disorders in Patients with Newly Diagnosed Glioblastoma

et al. 2021

View full text Add to dashboard Cite

Purpose: Disturbances of electrolytes and renal function have been linked to the prognosis of critically ill patients and recently also of cancer patients. This study aimed to assess electrolyte and renal disorders in glioblastoma patients and evaluate their prognostic effect. Methods: Medical records of patients with newly diagnosed glioblastoma between 2005 and 2018 were retrospectively reviewed for electrolyte and renal function parameters and for demographic, clinical and outcome parameters. Results: Electrolyte and renal function disorders were associated with poorer survival in univariate and Kaplan–Meier analysis. Multivariate analysis revealed hypochloremia as an independent prognostic factor for overall and 1-year survival. Conclusion: Only hypochloremia showed an association with glioblastoma prognosis, independent of other known prognostic factors, as age or molecular status.

show abstract

Section: Discussionsupporting

confidence: 85%

Electrolyte and Renal Disorders in Patients with Newly Diagnosed Glioblastoma

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Hyponatraemia is a common electrolyte disturbance in critical illness and malignancies. Many prospective and retrospective studies have indicated the occurrence of hyponatraemia and its importance as a prognostic factor in ICU patients [16], acute-on-chronic liver failure [17], glioblastoma [18], and lung cancer [19].…”

Section: Discussionmentioning

confidence: 99%

The prevalence and prognosis of hyponatraemia in non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis

Yin

Man

Huang

et al. 2021

Leukemia & Lymphoma

View full text Add to dashboard Cite

Background:Non-Hodgkin lymphoma associated hemophagocytic lymphohistiocytosis (NHL-HLH) in adult secondary HLH (sHLH) is a common and universally highly lethal critical disorder. Hyponatraemia is the most common electrolyte disorder in the critical illness setting and acts as a negative prognostic factor.The aim of our study was to evaluate the prognostic role of hyponatraemia among patients with NHL-HLH.Methods: This retrospective study enrolled 153 newly diagnosed adult NHL-HLH patients, which were divided into 2 groups based on serum sodium concentration on admission, a hyponatraemia and a normonatraemia group. Univariate and multivariateCox regression analysis were used to identify the prognostic factors associated with worse survival. The overall survival time of all the patients were compared using log rank tests. Restricted cubic splines were conducted to address the association between serum sodium concentration and the risk of mortality. Results:The results showed that 81 (52.9%) patients had hyponatraemia. After a median follow-up of 47 (range 14-180) days, there were 72 (88.9%) cumulative deaths in hyponatraemia group while 50 (69.4%) in normonatremia group. Univariate Cox regression analysis showed that hyponatraemia group demonstrated unfavourable overall survival (P = 0.002). After adjustment for confounders, multivariate analysis revealed that hyponatraemia was an independent prognostic factor for OS (Hazard ratio[HR]:1.51, 95% confidence interval [CI]: 1.03-2.20; P = 0.033). Restricted cubic spline confirmed a linear and positive association between serum sodium and the risk of mortality.Conclusions: Hyponatraemia is relatively frequent in NHL-HLH. As a readily available biomarker in clinical routine, it was a promising prognostic predictor for NHL-HLH.

show abstract

Section: Discussionmentioning

confidence: 99%

The prevalence and prognosis of hyponatraemia in non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis

Yin

Man

Huang

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Non-Hodgkin lymphoma associated hemophagocytic lymphohistiocytosis (NHL-HLH) in adult secondary HLH (sHLH) is a common and universally highly lethal critical disorder. Hyponatraemia is the most common electrolyte disorder in the critical illness setting and acts as a negative prognostic factor. The aim of our study was to evaluate the prognostic role of hyponatraemia among patients with NHL-HLH. Methods: This retrospective study enrolled 153 newly diagnosed adult NHL-HLH patients, which were divided into 2 groups based on serum sodium concentration on admission, a hyponatraemia and a normonatraemia group. Univariate and multivariate Cox regression analysis were used to identify the prognostic factors associated with worse survival. The overall survival time of all the patients were compared using log rank tests. Restricted cubic splines were conducted to address the association between serum sodium concentration and the risk of mortality. Results: The results showed that 81 (52.9%) patients had hyponatraemia. After a median follow-up of 47 (range 14-180) days, there were 72 (88.9%) cumulative deaths in hyponatraemia group while 50 (69.4%) in normonatremia group. Univariate Cox regression analysis showed that hyponatraemia group demonstrated unfavourable overall survival (P = 0.002). After adjustment for confounders, multivariate analysis revealed that hyponatraemia was an independent prognostic factor for OS (Hazard ratio [HR]:1.51, 95% confidence interval [CI]: 1.03-2.20; P = 0.033). Restricted cubic spline confirmed a linear and positive association between serum sodium and the risk of mortality. Conclusions: Hyponatraemia is relatively frequent in NHL-HLH. As a readily available biomarker in clinical routine, it was a promising prognostic predictor for NHL-HLH.

show abstract

The predictive potential of hyponatremia for glioblastoma patient survival

Cited by 6 publications

References 34 publications

Electrolyte and Renal Disorders in Patients with Newly Diagnosed Glioblastoma

Electrolyte and Renal Disorders in Patients with Newly Diagnosed Glioblastoma

The prevalence and prognosis of hyponatraemia in non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis

The prevalence and prognosis of hyponatraemia in non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis

Contact Info

Product

Resources

About