The pre-mir-27a variant rs895819 may contribute to type 2 diabetes mellitus susceptibility in an Iranian cohort

Ghaedi, Hamid; Tabasinezhad, Maryam; Alipoor, Behnam; Shokri, Fazlollah; Movafagh, Abolfazl; Mirfakhraie, Reza; Omrani, Mir Davood; Masotti, Andrea

doi:10.1007/s40618-016-0499-4

Cited by 25 publications

(22 citation statements)

References 27 publications

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“…Therefore, wild miR-27a may have a protective role against obesity and hence T2DM. It is conceivable that more active miR-27a (with the CC genotype) has a more protective role against T2DM as reported in previous studies [55,71]. Nevertheless, Wang et al 2015 have never observed the protecting effect of miR-27 against T2DM in the Chinese Han population [77].…”

Section: Mir-27a Rs895819mentioning

confidence: 88%

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Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

Elfaki

Mir

et al. 2019

JPM

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MicroRNAs (miRNAs) are endogenous, small (18–23 nucleotides), non-coding RNA molecules. They regulate the posttranscriptional expression of their target genes. MiRNAs control vital physiological processes such as metabolism, development, differentiation, cell cycle and apoptosis. The control of the gene expression by miRNAs requires efficient binding between the miRNA and their target mRNAs. Genome-wide association studies (GWASs) have suggested the association of single-nucleotide polymorphisms (SNPs) with certain diseases in various populations. Gene polymorphisms of miRNA target sites have been implicated in diseases such as cancers, diabetes, cardiovascular and Parkinson’s disease. Likewise, gene polymorphisms of miRNAs have been reported to be associated with diseases. In this review, we discuss the SNPs in miRNA genes that have been associated with diabetes and atherosclerotic cardiovascular disease in different populations. We also discuss briefly the potential underlining mechanisms through which these SNPs increase the risk of developing these diseases.

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Section: Mir-27a Rs895819mentioning

confidence: 88%

“…The rs895819 has been reported to be associated with decreased risk to T2DM in Italian and Iranian populations [55,71]. It has been suggested that rs895819T>C increased the expression of the miR-27a [55,[71][72][73]. It has been demonstrated that miR-27 exerts a negative effect on adipogenesis [74].…”

Section: Mir-27a Rs895819mentioning

confidence: 99%

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

Elfaki

Mir

et al. 2019

JPM

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“…We also observed strong correlations in subcutaneous adipose after gastric bypass and weight loss between miR‐27a‐5p and GLUT4 and NLRP3 mRNA and between NLRP3 protein levels and miR‐22 and miR‐24‐2‐5p (Figure ). miR‐27a‐5p has not been implicated in the regulation of NLRP3 to date, but miR‐27a was reported to play a role in insulin resistance by regulating GLUT4 signaling along with miR‐106b and miR‐30d ; a single‐nucleotide polymorphism in the pre‐27a miRNA is reported to be associated with T2D .…”

Section: Discussionmentioning

confidence: 99%

“…We also observed strong correlations in subcutaneous adipose after gastric bypass and weight loss between miR-27a-5p and GLUT4 and NLRP3 mRNA and between NLRP3 protein levels and miR-22 and miR-24-2-5p ( Figure 6). miR-27a-5p has not been implicated in the regulation of NLRP3 to date, but miR-27a was reported to play a role in insulin resistance by regulating GLUT4 signaling along with miR-106b and miR-30d (34); a single-nucleotide polymorphism in the pre-27a miRNA is reported to be associated with T2D (35,36). Given the role of inflammation in metabolic dysfunction, we were particularly interested in exploring the obesity-associated inflammasome NLRP3 (15) as an experimentally validated target of miR-223-3p (37).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA Profiling in Adipose Before and After Weight Loss Highlights the Role of miR‐223‐3p and the NLRP3 Inflammasome

Macartney-Coxson

Danielson

Clapham

et al. 2020

Obesity

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Objective Adipose tissue plays a key role in obesity‐related metabolic dysfunction. MicroRNA (miRNA) are gene regulatory molecules involved in intercellular and inter‐organ communication. It was hypothesized that miRNA levels in adipose tissue would change after gastric bypass surgery and that this would provide insights into their role in obesity‐induced metabolic dysregulation. Methods miRNA profiling (Affymetrix GeneChip miRNA 2.0 Array) of omental and subcutaneous adipose (n = 15 females) before and after gastric bypass surgery was performed. Results One omental and thirteen subcutaneous adipose miRNAs were significantly differentially expressed after gastric bypass, including downregulation of miR‐223‐3p and its antisense relative miR‐223‐5p in both adipose tissues. mRNA levels of miR‐223‐3p targets NLRP3 and GLUT4 were decreased and increased, respectively, following gastric bypass in both adipose tissues. Significantly more NLRP3 protein was observed in omental adipose after gastric bypass (P = 0.02). Significant hypomethlyation of NLRP3 and hypermethylation of miR‐223 were observed in both adipose tissues after gastric bypass. In subcutaneous adipose, significant correlations were observed between both miR‐223‐3p and miR‐223‐5p and glucose and between NLRP3 mRNA and protein levels and blood lipids. Conclusions This is the first report detailing genome‐wide miRNA profiling of omental adipose before and after gastric bypass, and it further highlights the association of miR‐223‐3p and the NLRP3 inflammasome with obesity.

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“…75 Ghaedi et al performed a study with 413 Iranians (204 T2DM, 209 healthy controls) and found that the C allele of miR-27a rs895819 was more frequently distributed in the control group and played a protective role against the developmental process of T2DM. 76 In addition, Wang et al found that the CC genotype of miR-27a rs895819 was significantly associated with the increased risk of T2DM in the obese group (24 ≤ body mass index ≤ 28). 75 Ciccacci et al demonstrated that the G allele of miR-27a rs895819 had a protective effect against the development of T2DM.…”

Section: Relationship Between Mirnas Snps and T2dmmentioning

confidence: 99%

MicroRNA single‐nucleotide polymorphisms and diabetes mellitus: A comprehensive review

et al. 2019

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Diabetes mellitus (DM) has become the third major chronic non‐communicable disease affecting global public health, following cancer and cardiovascular and cerebrovascular diseases. Although previous studies have found a correlation between microRNA (miRNA) and the development of DM, thus far, most reviews have focused on the studies describing the changes in miRNA expression profiles and the mechanisms by which miRNAs‐induce DM. However, reviews summarizing the effect of miRNA single‐nucleotide polymorphisms on the developmental stages of DM and its complications are still needed. Studies on the variation of miRNAs will not only help to further understand the role that genetic factors play in DM, but will also have important implications for treatment and disease prognosis.

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The pre-mir-27a variant rs895819 may contribute to type 2 diabetes mellitus susceptibility in an Iranian cohort

Cited by 25 publications

References 27 publications

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

MicroRNA Profiling in Adipose Before and After Weight Loss Highlights the Role of miR‐223‐3p and the NLRP3 Inflammasome

MicroRNA single‐nucleotide polymorphisms and diabetes mellitus: A comprehensive review

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