In the current political climate, people of Indigenous Mexican ancestry living in the United States (PIMA-US) are facing adverse social conditions that affect their overall health, for example, anti-immigrant sentiments, legal abandonment, and identity-based fear. This isthe latest chapter in a history of traumatic events that provides context for understandingthe mental health trajectory of this population. This scoping review identifies and examines research that uses a historical perspective to study current mental health and substance abuse disorders (SUDs) for PIMA-US. Sixteen peer-reviewed articles, published from 1998 through 2018, were selected using the scoping methodological framework. Thematic analysis yielded three overarching topics: (a) historic traumatic events (HTEs), (b) popular culture as a vehicle of transmission of historical trauma narratives, and (c) behavioral health responses to historical trauma, such as reliance on cultural heritage, and institutional mistrust. This research views the current health disparities of PIMA-US as the cumulative effect of historical and ongoing oppression. This integratedreview broadens the baseline knowledge for the diagnosis, treatment, and prevention ofcontemporary traumatic exposures for PIMA-US. It provides an opportunity to develophistorically informed trauma interventions that are more sustainable because they emphasize survival through the practice of intergenerational wellness traditions.