The practical use of cytology for diagnosis in dermatology

Ruocco, Eleonora; Brunetti, Giampiero; Vecchio, Michele Del; Ruocco, Vincenzo

doi:10.1111/j.1468-3083.2010.03740.x

Cited by 46 publications

(51 citation statements)

References 16 publications

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“…Awareness of characteristic cytological features can help in reaching a correct diagnosis even in a clinically unsuspected case. 11 The previous experience of the cytopathologist with cytodiagnosis of MC was helpful in the present case reported here. 5 …”

Section: Figure 2bmentioning

confidence: 65%

Cytological diagnosis of molluscum contagiosum with an unusual clinical presentation at an unusual site

Kumar

Okiro²,

Wasike³

2011

J Dermatol Case Rep

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Section: Figure 2bmentioning

confidence: 65%

Cytological diagnosis of molluscum contagiosum with an unusual clinical presentation at an unusual site

Kumar

Okiro²,

Wasike³

2011

J Dermatol Case Rep

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“…The results of a meta-analysis have demonstrated that this test has a very high sensitivity (97%, 95% CI 94 -99) and specificity (86%, 95% CI 80 -91) (20). The high accuracy of TST for margin control was encouraging to propose an applied evaluation alternative approach for well-demarcated BCC therapy (21) or other tumoral lesions (22). Compared with FS examination as "gold method for diagnosis of BCC" in study of Baba et al (21) the sensitivity and specificity of TST for margin evaluation was 1.00 (95% CI = 1.00 -1.00) and 0.99 (95% CI = 0.98 -1.00), whereas positive and negative predictive values and diagnostic accuracy were 0.94 (95% CI = 0.84 -1.05), 1.00 (95% CI = 1.00 -1.00), and 1.00 (95% CI =0.99 -1.00), respectively.…”

Section: Discussionmentioning

confidence: 99%

A Diagnostic Accuracy Comparison Between Tzanck Smear Test and Frozen Section Examination in Basal Cell Carcinoma

et al. 2017

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Background: Mohs' micrographic surgery is a suitable treatment and frozen section (FS) examination is the "gold standard" of surgical margins in tumoral skins. This study compared the diagnostic accuracy between the Tzanck smear test (TST) and frozen section (FS) examination for margin control in surgery for basal cell carcinoma (BCC). Methods: Fifty-nine patients with basal cell carcinoma (BCC) were included. The tumor was excised and the Tzanck smear test (TST) was taken for Papanicolaou staining (Pap staining) and reconfirmation of tumoral cells. Then a dermatologist took margins of tumoral mass. TST was taken from the margins and sent to the dermatopathologist for Pap staining. After dying, each marked fragment was sectioned separately with cryostat. Finally, diagnostic accuracy of TST compared with FS examination was analyzed. Results: The sensitivity and specificity of TST for the evaluation of margin were 0.28 and 0.95; whereas positive and negative predictive values were 0.54 and 0.85, respectively. Positive and negative likelihood values were 5.36 and 0.76, respectively. Diagnostic accuracy was 0.82. The kappa coefficient of agreement between the two methods was 0.28 (P < 0.001). Conclusions: Positive likelihood value and specificity of TST for the evaluation of margin were high; therefore, TST can be suitable in the diagnosis of BCC, but due to low sensitivity and kappa coefficient, TST alone cannot be a suitable alternative method compared to the FS examination for margin control in BCC.

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“…Cytology is very important to distinguish between the two autoimmune blistering diseases (15). In pemphigus, cytology reveals numerous single or loosely adherent clumps of acantholytic cells (16). If the test is positive for acantholytic cells, direct immunofluorescence test on smear can be performed (17).…”

Section: Discussionmentioning

confidence: 99%

Cytologic Findings of Eosinophilic Dermatoses: a Retrospective Analysis of 88 Patients

Durdu¹

2016

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Objectives: Eosinophilic skin infiltration may develop as a result of a variety of infectious, inflammatory, and neoplastic diseases. To distinguish these diseases histopathologic examination is usually considered. So far, only a few studies have investigated cytologic findings of some eosinophilic diseases. In this retrospective study, our aim was to define the cytologic findings of eosinophilic dermatoses and to develop an algorithmic approach based on the cytologic findings. Methods: Patients who applied to the dermatology polyclinic through January 2010 to January 2015 could not be diagnosed only by clinical examination were further evaluated with May-Grunwald-Giemsa-stained preparations by a dermatologist. Patients with abundant eosinophils in microscopic examination were included in this study. After routine cytologic examination additional staining was also performed in some of these patients. The final diagnosis was established according to their clinical laboratory and histopathologic findings. Results: Over a 5-year period, 88 of 3.214 patients (2.7%) who underwent cytologic examination at our center had plenty of eosinophils. According to the final diagnoses, 44 lesions (50%) were spongiotic dermatitis, 17 lesions (19.3%) were infectious diseases, 13 lesions (14.8%) were autoimmune bullous, 11 lesions (12.5%) were idiopathic eosinophilic diseases, and 3 lesions (3.4%) were granulomatous diseases. Conclusion: Cytologic examination of people with eosinophilic skin diseases cytologic findings accompanying eosinophils could help for diagnosis of some diseases. Keywords: Cytology, dermatitis, eosinophils, eosinophilic pustular folliculitis, eosinophilic cellulitis, pemphigus Murat Durdu

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The practical use of cytology for diagnosis in dermatology

Cited by 46 publications

References 16 publications

Cytological diagnosis of molluscum contagiosum with an unusual clinical presentation at an unusual site

Cytological diagnosis of molluscum contagiosum with an unusual clinical presentation at an unusual site

A Diagnostic Accuracy Comparison Between Tzanck Smear Test and Frozen Section Examination in Basal Cell Carcinoma

Cytologic Findings of Eosinophilic Dermatoses: a Retrospective Analysis of 88 Patients

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