The potential value of dequalinium chloride in the treatment of cancer: Focus on malignant glioma

Pan, Yuehai; Zhao, Shuai; Chen, Fan

doi:10.1111/1440-1681.13466

Cited by 18 publications

(11 citation statements)

References 109 publications

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“…From a total of 17 compounds, 7 were cytotoxic (IC 50 <200 µM), inhibiting PC‐3, LNCaP, and MatLyLu cell viability, and the most active compound 10 was also active against nontumor prostate cells, benign hyperplastic prostatic epithelial cells (BPH‐1); however, it showed a more specific response to tumor cells than dequalinium, a drug used as a reference. [ 33,34 ] The results are summarized in Table 2.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of 5H‐indeno[1,2‐b]pyridine derivatives: Antiproliferative and antimetastatic activities against two human prostate cancer cell lines

Charris

Rodrígues

Ramírez

et al. 2021

Archiv der Pharmazie

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This study describes the direct synthesis of 2‐amino‐4‐(phenylsubstituted)‐5H‐indeno[1,2‐b]pyridine‐3‐carbonitrile derivatives 5–21, through sequential multicomponent reaction of aromatic aldehydes, malononitrile, and 1‐indanone in the presence of ammonium acetate and acetic acid (catalytic). The biological study showed that compound 10 significantly impeded proliferation of the cell lines PC‐3, LNCaP, and MatLyLu. The antimetastatic effects of compound 10 could be related with inhibition of MMP9 in the PC‐3 and LNCaP human cell lines. On the basis of a study of the structure–activity relationship of these compounds, we propose that the presence of two methoxy groups at positions 6 and 7 of the indeno nucleus and a 4‐hydroxy‐3‐methoxy phenyl substitution pattern at position 4 of the pyridine ring is decisive for these types of molecules to exert very good antiproliferative and antimetastatic activities.

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Section: Resultsmentioning

confidence: 99%

Synthesis of 5H‐indeno[1,2‐b]pyridine derivatives: Antiproliferative and antimetastatic activities against two human prostate cancer cell lines

Charris

Rodrígues

Ramírez

et al. 2021

Archiv der Pharmazie

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“…Glioblastoma multiforme (GBM) is the most common and most aggressive malignant tumor of the central nervous system in adults ( Pan et al, 2021b ). Nowadays, in the treatment of GBM, the technique of resection, radiation therapy, and chemotherapeutic drugs have made progress, but survival has not been significantly prolonged ( Yu et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of m6A Regulator-Mediated Methylation Modification and Tumor Microenvironment Infiltration in Glioblastoma Multiforme

Wang

Cao

Zhong

et al. 2022

Front. Cell Dev. Biol.

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N6-methyladenosine (m6A) RNA methylation is an emerging epigenetic modification in recent years and epigenetic regulation of the immune response has been demonstrated, but the potential role of m6A modification in GBM tumor microenvironment (TME) cell infiltration and stemness remain unknown. The m6A modification patterns of 310 GBM samples were comprehensively evaluated based on 21 m6A regulators, and we systematically correlated these modification patterns with TME cell infiltration characteristics and stemness characteristics. Construction of m6Ascore to quantify the m6A modification patterns of individual GBM samples using a principal component analysis algorithm. We identified two distinct patterns of m6A modification. The infiltration characteristics of TME cells in these two patterns were highly consistent with the immunophenotype of the GBM, including the immune activation differentiation pattern and the immune desert dedifferentiation pattern. We also identified two modes of regulation of immunity and stemness by m6A methylation. Stromal activation and lack of effective immune infiltration were observed in the high m6Ascore subtype. Pan-cancer analysis results illustrate a significant correlation between m6AScore and tumor clinical outcome, immune infiltration, and stemness. Our work reveals that m6A modifications play an important role in the development of TME and stemness diversity and complexity. Patients with a low m6AScore showed significant therapeutic advantages and clinical benefits. Assessing the m6A modification pattern of individual tumors will help enhance our knowledge of TME infiltration and stemness characteristics, contribute to the development of immunotherapeutic strategies.

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“…Low grade gliomas (LGG), including WHO grade II and III, are common primary tumors in the CNS, accounting for approximately 20-29% of primary CNS tumors [8,9]. LGG has the potential to evolve into glioblastoma (GBM), but LGG is less aggressive than GBM, with a median survival time of more than 7 years, unlike GBM, which has a 5-year survival rate of 4-5% [9,10]. The main treatment method for LGG remains surgical resection, but surgery does not completely stop the recurrence of LGG due to the presence of glioma stem cells and immune cell in ltration of the tumor microenvironment (TME) [11,12].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Influence of S1PR3 expression on the glioma microenvironment and prognostic significance in low-grade gliomas

Chen

Zhong

Xie

et al. 2022

Preprint

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Background The S1P/S1PR3 axis has been demonstrated to be associated with the development of multiple human cancers, but the potential role of it in the biological mechanisms of glioma, par-ticularly TME cell infiltration, remains unknown. Methods We analyzed gene expression data of gliomas and corresponding clinicopathological information to assess overall survival by univariate and multivariate Cox regression. We also analyzed the signaling pathways and genes associated with S1PR3 overexpression by Gene Set Enrichment Analysis, and the characteristics of oncogenic pathways, biological pathways, and TME cell infiltration, and validated the results with PCR, cell proliferation, and migration assays. Results Cox regression analysis confirmed that S1PR3 overexpression was significantly correlated with overall survival and clinicopathological features. Nomogram for prognostic prediction was successfully constructed using S1PR3 and related genes, and Gene Set Enrichment Analysis revealed the association of S1PR3 overexpression with cell cycle, DNA replication, MAPK, p53 and TGF-β signaling pathway. Meanwhile, S1PR3 was shown to be significantly associated with many immune checkpoints and immune cell infiltration. Conclusions Our study demon-strated that S1PR3 overexpression is a potential prognostic molecular marker for poor prognosis in glioma, that S1PR3 plays an important role in immune cell infiltration in TME. And identification of S1PR3-regulated signaling pathways and immune checkpoints enhances our understanding of TME infiltration characteristics, contributes to the development of immunotherapeutic strategies.

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The potential value of dequalinium chloride in the treatment of cancer: Focus on malignant glioma

Cited by 18 publications

References 109 publications

Synthesis of 5H‐indeno[1,2‐b]pyridine derivatives: Antiproliferative and antimetastatic activities against two human prostate cancer cell lines

Synthesis of 5H‐indeno[1,2‐b]pyridine derivatives: Antiproliferative and antimetastatic activities against two human prostate cancer cell lines

The Role of m6A Regulator-Mediated Methylation Modification and Tumor Microenvironment Infiltration in Glioblastoma Multiforme

RETRACTED: Influence of S1PR3 expression on the glioma microenvironment and prognostic significance in low-grade gliomas

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