The potential role of the elastic fiber system in adolescent idiopathic scoliosis.

Hadley-Miller, Nancy; Mims, Betsy H.; Milewicz, Dianna M.

doi:10.2106/00004623-199408000-00010

Cited by 59 publications

(29 citation statements)

References 48 publications

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“…Collagen and elastic fibres are principal elements in the supporting structures of the spinal column and have been the focus of many studies dealing with the pathophysiology of AIS. Hadley-Miller et al [20] reported elastic fibre abnormalities in the spinal ligaments in a substantial number of patients with AIS, compared with those of normal individuals.…”

Section: Macro-and Micro-structural Abnormalitiesmentioning

confidence: 99%

Recent advances in the aetiology of adolescent idiopathic scoliosis

Cheung

Wang

Qiu

et al. 2007

International Orthopaedics (SICO

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The aetiology of adolescent idiopathic scoliosis (AIS) is still unknown despite many years of research effort. Theories on AIS's aetiology have included mechanical, hormonal, metabolic, neuromuscular, growth, and genetic abnormalities. Amongst these, some factors may be epiphenomena rather than the cause itself. Other factors may even contribute to curve progression, rather than curve initiation. Current views maintain that AIS is a multifactorial disease with genetic predisposing factors [Lowe et al. in J Bone Joint Surg [Am] 82:1157-1168, 2000. With improvements in diagnostic methods, imaging and genomics, there has been considerable recent work on aetiology. This review aims to bring readers up-to-date with the latest developments in scoliosis research.Résumé L'étiologie de la scoliose idiopathique de l'adolescent (AIS) reste inconnue en dépit de nombreux travaux et de nombreux efforts de recherche. Dans les théories voulant expliquer une scoliose, on cherche à mettre en évidence des facteurs mécaniques, hormonaux, méta-boliques, neuro musculaires, au niveau de la croissance mais aussi des anomalies d'origine génétique. Parmi tous ces facteurs, certains d'entre eux sont des épiphénomènes, certains facteurs peuvent contribuer à la progression de la courbure scoliotique ou à son apparition. De nombreux points de vue permettent de penser que l'AIS est une maladie d'origine multi factorielle avec des facteurs prédisposant d'origines génétiques. L'amélioration des méthodes de diagnostic, d'imageries et d'analyses génét-iques contribue à mieux approcher cette étiologie. Ce travail a pour but de mettre en évidence les facteurs les plus actuels dont on peut penser qu'ils sont à l'origine du développement d'une scoliose.

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Section: Macro-and Micro-structural Abnormalitiesmentioning

confidence: 99%

Recent advances in the aetiology of adolescent idiopathic scoliosis

Cheung

Wang

Qiu

et al. 2007

International Orthopaedics (SICO

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“…Electron microscopic examinations confirmed the presence of elastic fibers in their mature form. In the adult human, it is reported that elastic fibers in the ligamentum flavum are nearly homogeneous in diameter, and are aligned regularly in the cephalocaudal direction (Handley-Miller et al 1994;Mikawa et al 1986). In our observation, the elastic fibers in the ligamenta flava are also aligned regularly in the horizontal direction in the early and late-stage fetuses.…”

Section: Discussionmentioning

confidence: 99%

Innervation and functional characteristics of connective tissues, especially elastic fibers, in human fetal thoracic intervertebral articular capsule and its surroundings

et al. 2003

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The articular capsules between the thoracic vertebrae, which have physiologically different functions from those of other levels of the vertebrae, have yet to be subjected to neuro-anatomical and fine structural analysis. In the present study, we analyzed serial frozen sections of decalcified thoracic vertebrae in human fetuses, and identified the articular capsule tissue with its unique distribution of elastic fibers. The fine structure of the elastic fibers was studied by transmission electron microscopy. In the early-stage fetus, the fibrous membrane forming the lateral intervertebral articular capsule contained abundant thin elastic fibers consisting of microfibrils. In the late-stage fetus, the lateral capsule of fibrous membrane was occupied by thick elastic fibers. A medial articular capsule, namely the ligamenta flava, contained numerous thick elastic fibers in both early and late-stage fetuses. The distributional differences in nerve fibers between early and late-stage fetuses were determined by immunostaining, using antibodies raised against protein gene product 9.5 (PGP 9.5; ubiquitin carboxyl-terminal hydrolase). Innervation by PGP 9.5 immunoreactive fibers was limited to the areas of the articular capsules near the blood vessels, which may indicate their functional relation with blood flow. No PGP 9.5 immunoreactive fibers were found in the ligamenta flava of the late-stage fetus. Innervation might be directly involved in the development of the intervertebral articular capsules in normal human fetuses.

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“…Des altérations du collagène seraient aussi reliées à des facteurs environnementaux notamment une insuffisance en cuivre déclenchant une scoliose, car le cuivre intervient dans la régulation de la lysiloxydase, chaînon important du métabolisme du collagène [10]. Dans ce contexte, il n'est donc pas surprenant que les principaux éléments des structures vertébrales, soit le collagène et les protéoglycanes, aient été analysés dans l'espoir d'élucider la cause de la SIA [11,12]. Ces différents changements de points de vue sont résumés au Tableau 1.…”

Section: éLéments Structuraux Du Rachisunclassified

“…Calcium et phosphore intracellulaires élevés [20] Taux augmenté de calmoduline [21] Protéines structurales Fibrilline Désorganisation des fibres [11] Collagène / Protéoglycanes Dégénérescence du collagène [12] Accumulation d'agrégats de protéoglycanes…”

Section: Plaquettes Sanguinesunclassified