The Potential Role of PTPN-22 C1858T Gene Polymorphism in the Pathogenesis of Type 1 Diabetes in Saudi Population

Alswat, Khaled; Dubayee, Mohammed S. Al; Talaat, Iman M.; Alsulaimani, Adnan Amin; Mohamed, Imad; Allam, Gamal

doi:10.1080/08820139.2018.1458109

Cited by 4 publications

(1 citation statement)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PTPN-22 is inhibitor of effector/ memory T-cell pool required to preserve the balance in immune system [ 53 ]. There was a correlation between PTPN-22 1858 T polymorphism and T1D susceptibility among Saudi individuals [ 54 ]. PTPN22 SNPs (rs12760457, rs1310182, rs1217414, rs33996649, and rs2476601) were correlated with T1D among Iranians [ 55 ].…”

Section: Introductionmentioning

confidence: 99%

Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

et al. 2022

View full text Add to dashboard Cite

Diabetes is a chronic metabolic disorder that leads to the dysfunction of various tissues and organs, including eyes, kidneys, and cardiovascular system. According to the World Health Organization, diabetes prevalence is 8.8% globally among whom about 90% of cases are type 2 diabetes. There are not any significant clinical manifestations in the primary stages of diabetes. Therefore, screening can be an efficient way to reduce the diabetic complications. Over the recent decades, the prevalence of diabetes has increased alarmingly among the Middle East population, which has imposed exorbitant costs on the health care system in this region. Given that the genetic changes are among the important risk factors associated with predisposing people to diabetes, we examined the role of single-nucleotide polymorphisms (SNPs) in the pathogenesis of diabetes among Middle East population. In the present review, we assessed the molecular pathology of diabetes in the Middle East population that paves the way for introducing an efficient SNP-based diagnostic panel for diabetes screening among the Middle East population. Since, the Middle East has a population of 370 million people; the current review can be a reliable model for the introduction of SNP-based diagnostic panels in other populations and countries around the world.

show abstract

Section: Introductionmentioning

confidence: 99%

Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

et al. 2022

View full text Add to dashboard Cite

show abstract

Association of CTLA-4 and CD28 Gene Polymorphisms with Type 1 Diabetes in South Indian Population

Nagarajan

Asirvatham

Chitra

et al. 2019

Immunological Investigations

View full text Add to dashboard Cite

The Relationship between PTPN22 R620W Polymorphisms and the Susceptibility to Autoimmune Thyroid Diseases: An Updated Meta-analysis

Wan

et al. 2020

Immunological Investigations

View full text Add to dashboard Cite

The Potential Role of PTPN-22 C1858T Gene Polymorphism in the Pathogenesis of Type 1 Diabetes in Saudi Population

Abstract: The data presented here suggests that the T allele of PTPN-22 C1858T polymorphism might be a risk factor for T1D development in Saudi children.

Cited by 4 publications

References 63 publications

Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

Association of CTLA-4 and CD28 Gene Polymorphisms with Type 1 Diabetes in South Indian Population

The Relationship between PTPN22 R620W Polymorphisms and the Susceptibility to Autoimmune Thyroid Diseases: An Updated Meta-analysis

Contact Info

Product

Resources

About