The Potential Role of Nitric Oxide in Halting Cancer Progression Through Chemoprevention

Vahora, Huzefa; Khan, Munawwar Ali; ALAlami, Usama; Hussain, Arif

doi:10.15430/jcp.2016.21.1.1

Cited by 113 publications

(69 citation statements)

References 87 publications

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“…The anticancer effect of EGCG, through inhibition of NO . production, has been observed in many different tumors [48][49][50][51]. In TRAMP mice who received, 0.06% EGCG in tap water ad libitum for 7 weeks starting at weaning, a reduction of the HG-PIN incidence was observed, concomitantly with a significant downregulation of iNOS [52].…”

Section: Effects Of Gtcs On Nos Productionmentioning

confidence: 91%

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Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

Naponelli¹,

Ramazzina²,

Lenzi³

et al. 2017

Preprint

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Green Tea Catechins (GTCs) are a family of chemically related compounds usually classified as antioxidant molecules. Epidemiological evidences, supported by interventional studies, highlighted a more than promising role for GTCs in human Prostate Cancer (PCa) chemoprevention.In the last decades many efforts have been made to gain new insights into the mechanism of action of GTCs. Now it is clear that GTCs anticancer action can no longer be simplistically limited to their direct antioxidant/pro-oxidant properties. Recent contributions to the advancement of knowledge in this field have shown that GTCs specifically interact with cellular targets including, cell surface receptors, lipid rafts and endoplasmic reticulum, modulate gene expression through direct effect on transcription factors or indirect epigenetic mechanisms, interfere with intracellular proteostasis at various levels. Many of the effects observed in vitro are dose and cell context dependent and take place at concentration that cannot be achieved in vivo.Poor intestinal absorption together with an extensive systemic and enteric metabolism influence GTCs bioavailability through still poor understood mechanisms. Recent efforts to develop delivery systems that increase GTCs overall bioavailability, by mean of biopolymeric nanoparticles, represent the main way to translate preclinical results in a real clinical scenario for PCa chemoprevention.

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Section: Effects Of Gtcs On Nos Productionmentioning

confidence: 91%

“…is associated with tumor cell proliferation and angiogenesis, instead at high concentrations (more than 500 nM) NO . exerts a cytotoxic effect [48]. The anticancer effect of EGCG, through inhibition of NO .…”

Section: Effects Of Gtcs On Nos Productionmentioning

confidence: 99%

Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

Naponelli¹,

Ramazzina²,

Lenzi³

et al. 2017

Preprint

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“…EcSOD, in preserving bioavailability of NO • , is expected to have an indirect consequential effect in cancer through alterations of these NO /ONOO − signaling. The seemingly paradoxical role of NO • in cancer has been quite extensively covered in other reviews [83] and is not discussed in detail here.…”

Section: Ecsod As a Primary Defense Against Other Ros And Rnsmentioning

confidence: 99%

Extracellular superoxide dismutase and its role in cancer

Griess

Tom

Domann

et al. 2017

Free Radical Biology and Medicine

144

124

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Reactive oxygen species (ROS) are increasingly recognized as critical determinants of cellular signaling and a strict balance of ROS levels must be maintained to ensure proper cellular function and survival. Notably, ROS is increased in cancer cells. The superoxide dismutase family plays an essential physiological role in mitigating deleterious effects of ROS. Due to the compartmentalization of ROS signaling, EcSOD, the only superoxide dismutase in the extracellular space, has unique characteristics and functions in cellular signal transduction. In comparison to the other two intracellular SODs, EcSOD is a relatively new comer in terms of its tumor suppressive role in cancer and the mechanisms involved are less well understood. Nevertheless, the degree of differential expression of this extracellular antioxidant in cancer versus normal cells/tissues is more pronounced and prevalent than the other SODs. A significant association of low EcSOD expression with reduced cancer patient survival further suggests that loss of extracellular redox regulation promotes a conducive microenvironment that favors cancer progression. The vast array of mechanisms reported in mediating deregulation of EcSOD expression, function, and cellular distribution also supports that loss of this extracellular antioxidant provides a selective advantage to cancer cells. Moreover, overexpression of EcSOD inhibits tumor growth and metastasis, indicating a role as a tumor suppressor. This review focuses on the current understanding of the mechanisms of deregulation and tumor suppressive function of EcSOD in cancer.

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“…Although NOS catalyzes the reaction, production of NO is also facilitated by NADH and oxygen. The actions of NO are mainly mediated through cGMP-dependent manner as well as Advances in Breast Cancer Research cGMP-independent manner, typically through NO targeting the heme component of soluble guanylyl cyclase, which further undergoes coupling with c-GMP-dependent protein kinase G and phosphodiesterases as well as cyclic nucleotide gated channels [111]. When produced the, relatively small free radical, water soluble, NO is capable of diffusing out and stimulating a diverse range of cellular events, such as vasodilation and inflammation, however, NO is unstable and breaks down easily.…”

Section: The Vasodilator No Participates In Angiogenesismentioning

confidence: 99%

Role of ESR Pathway Genes in Breast Cancer: A Review

Kumar¹,

Myers²,

Homsi³

et al. 2018

ABCR

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Breast cancer is the leading cause of death in women. Prognosis of breast cancer is often pessimistic because the tumors are prone to metastasizing to the bone, brain, and lung. The estrogen signaling receptor (ESR) pathway contains 39 main genes and proteins which makes it one of the larger signaling pathways. Predominately this pathway and the proteins within are involved in breast growth and development, making it a prospective area of study for breast cancer. While the healthy ESR pathway has been constructed and is well established, a mechanistic model of mutated genes of ESR pathway has not been delved upon. Such mutated models could be utilized for selecting combinational targets for drug therapies, as well as elucidating crosstalk between other pathways and feedback mechanisms. To construct the mutated models of the ESR pathway it is imperative to assess what is currently understood in the literature and what inconsistencies exist in order to resolve them. Without this information, a model of the ESR pathway will be unreliable and likely unproductive. This review is the detailed literature survey of the biological studies performed on ESR pathways genes, and their respective roles in breast cancer. Furthermore, the details mentioned in the review can be beneficial for the integrated study of the ESR pathway genes, which includes, structural and dynamics study of the genes products, to have a holistic understanding of the cancer mechanism.

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The Potential Role of Nitric Oxide in Halting Cancer Progression Through Chemoprevention

Cited by 113 publications

References 87 publications

Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

Extracellular superoxide dismutase and its role in cancer

Role of ESR Pathway Genes in Breast Cancer: A Review

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