The author has indicated no significant interest with commercial supporters.T he use of platelet-rich plasma (PRP) has been investigated in numerous fields of medicine, particularly for its role in wound healing. These fields include orthopedics, dentistry, and most recently dermatology. Data published in peer-reviewed journals have demonstrated dermatologic applications in areas ranging from acne scarring 1 to lower extremity wound healing 2 to fat transplantation. 3 Thicker collagen bundles were seen in skin treated with PRP than in control areas after ablative fractional carbon dioxide laser resurfacing. 4 Basic scientific data suggest that the mechanism of action for PRP is by upregulating levels of type I collagen, matrix metalloproteinase (MMP)-1, and MMP-2. It also appears to increase the expression of G1 cell cycle regulators. 5