Commentary on Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

Abstract

The author has indicated no significant interest with commercial supporters.T he use of platelet-rich plasma (PRP) has been investigated in numerous fields of medicine, particularly for its role in wound healing. These fields include orthopedics, dentistry, and most recently dermatology. Data published in peer-reviewed journals have demonstrated dermatologic applications in areas ranging from acne scarring 1 to lower extremity wound healing 2 to fat transplantation. 3 Thicker collagen bundles were seen in skin treated with PRP than in control areas after ablative fractional carbon dioxide laser resurfacing. 4 Basic scientific data suggest that the mechanism of action for PRP is by upregulating levels of type I collagen, matrix metalloproteinase (MMP)-1, and MMP-2. It also appears to increase the expression of G1 cell cycle regulators. 5

A Novel and Convenient Method for the Preparation and Activation of PRP without Any Additives: Temperature Controlled PRP

“…Fifteen days after surgery, the wounds in both t-PRP and c-PRP treatment group were reepithelialized completely, without obvious crust formation during the process ( Figure 6(b) ). These findings suggest that t-PRP has a similar function of promoting wound healing to c-PRP in vivo , as previously reported [ 1 , 25 , 26 ].…”

The effect of autologous activated platelet‐rich plasma injection on female pattern hair loss: A randomized placebo‐controlled study

“…Recently, it has also been found to be beneficial in dermatology, for example, in acne scarring, wound healing, and fat transplantation. It has also been shown to promote hair survival and growth, both in vitro and in vivo …”

“…It has also been shown to promote hair survival and growth, both in vitro and in vivo. [6][7][8] The basic idea behind PRP injection is to deliver high concentrations of growth factors to the scalp, with the hope of stimulating hair regrowth. 4 This prospective randomized placebo-controlled study was conducted to evaluate the efficacy and safety of autologous PRP in the treatment of female pattern hair loss.…”

Platelet-Rich Plasma for Androgenetic Alopecia

“…10 Most recently, intradermal injections of PRP at the thinning scalp site in 26 patients were shown to markedly increase hair diameter, whereas histologic findings showed a thickened epithelium, proliferation of collagen fibers and fibroblasts, and increased vessels around follicles. 11,12 We conducted this study to verify whether such a cellular and biologically oriented approach could represent an alternative to traditional therapies in maleand female-pattern androgenetic alopecia. In fact, miniaturized hair follicles maintain the same number of epithelial hair follicle stem cells in the bulge region on their outer root sheath as do the large terminal follicles.…”