The effect of autologous activated platelet‐rich plasma injection on female pattern hair loss: A randomized placebo‐controlled study

Tawfik, Abeer Attia; Osman, Mai

doi:10.1111/jocd.12357

Cited by 73 publications

(78 citation statements)

References 17 publications

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“…While early journal publications on PRP largely focused on case series reports, some comparative control studies have been conducted in humans, albeit using a variety of treatment regimens . Arguably, the most relevant trial design for local scalp injections of PRP is an intra‐control, defined area, quantitative analysis study.…”

Section: Introductionmentioning

confidence: 99%

Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

Siah

Guo

Chu

et al. 2020

Experimental Dermatology

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Background Platelet‐rich plasma (PRP), processed from autologous peripheral blood, is used to treat androgenetic alopecia (AGA). Objective To determine the efficacy of PRP for hair growth promotion in AGA patients in a randomized, blinded, placebo‐controlled, pilot clinical trial (NCT02074943). Methods The efficacy of an 8 week, five session, PRP treatment course was determined by measuring hair density and hair caliber changes in 10 AGA affected patients. For each PRP sample, the concentrations of selected growth factors were determined using a multiplex assay system. The clinical results were then correlated with the growth factor concentrations in PRP. Results At 16 weeks, 8 weeks after the last PRP injection, treated areas exhibited increased mean hair density (+12.76%) over baseline compared to placebo (+0.99%). Mean hair caliber decreased in both treated and placebo regions (−16.22% and −19.46%, respectively). Serial analysis of PRP significant variability in concentrations between patients. Overall, there was a positive correlation between GDNF concentration and hair density (P = .004). Trends, though not statistically significant, were also observed for FGF2 and VEGF. Limitations Small sample size and lack of comparative cohorts receiving protocol variations limit confidence in the study data. Conclusions This small pilot clinical trial suggests PRP treatment may be beneficial for AGA. However, the variable hair growth responses between patients indicate there is a significant opportunity to improve PRP therapy protocols for hair growth promotion. The variability in growth factor concentration in PRP suggests standardization of growth factors postprocessing might improve hair growth responses.

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Section: Introductionmentioning

confidence: 99%

Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

Siah

Guo

Chu

et al. 2020

Experimental Dermatology

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“…The forest plot in Figure shows that the study data favored PRP on increasing hair density in males and females when compared to placebo with a pooled mean difference of 30.35 (95% confidence interval 1.77‐58.93) and a P value of less than 0.00001. Five of those seven studies reported statistically significant results in favor of PRP . Difference of data between the groups of the rest of two studies was not statistically significant and did not favor any treatment group .…”

Section: Resultsmentioning

confidence: 90%

“…Three studies applied co‐interventions (minoxidil, finasteride, or polydeoxyribonucleotide) in addition to PRP in the experimental group and applied the same intervention in the control group without PRP . The rest of 10 studies compared platelet‐rich plasma to placebo (normal saline or distilled water) . If studies included males, then the studies used the Hamilton‐Norwood classification to categorize progression of male pattern hair loss.…”

Section: Resultsmentioning

confidence: 99%

“…Alves 2018 compared PRP plus minoxidil or finasteride accordingly vs placebo plus minoxidil or finasteride accordingly. The rest of six studies compared PRP vs placebo (normal saline)…”

Section: Resultsmentioning

confidence: 99%

“…We provide an overview of the outcomes and time point of assessment in Table . Data of seven studies on the outcome hair density were included in the meta‐analysis . One of those seven studies compared PRP plus minoxidil or finasteride vs placebo plus minoxidil or finasteride accordingly .…”

Section: Resultsmentioning

confidence: 99%

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Autologous platelet‐rich plasma therapy for pattern hair loss: A systematic review

Dervishi

Peternel

et al. 2019

J of Cosmetic Dermatology

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Background Androgenetic alopecia (male pattern and female pattern hair loss) is characterized by thinning of the scalp hair. Intradermal injection of autologous platelet‐rich plasma (PRP) might have an effect on hair regrowth. Aims The aim was to evaluate efficacy and safety of platelet‐rich plasma compared to placebo or no treatment in people with pattern hair loss. Patients/Methods We searched the databases CENTRAL and MEDLINE on December 24, 2018 and included randomized controlled trials (RCTs). Primary outcomes were mean change of hair density from baseline and serious treatment‐related adverse events. Secondary outcome was mean change of hair thickness from baseline. Time point of outcome assessment was 6 months after start of treatment. Results We identified 13 relevant randomized controlled trials with 356 randomized (343 analyzed) people or half‐head areas who received PRP in a simple parallel or half‐head design. The pooled data of seven studies (171 analyzed people or half‐head areas) were favorable in the PRP group on hair density. We estimated a mean difference from baseline of 30.35 associated with a wide 95% confidence interval (1.77‐58.93), a considerable heterogeneity (I2 = 100%), and unclear risk of bias in most of the studies. Regarding hair thickness, data were also favorable in the PRP group, but these data were limited to a single study. We did not identify serious treatment‐related adverse events. Conclusion The results of seven RCTs indicated that autologous platelet‐rich plasma was associated with an increase of hair density when compared to placebo.

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Autologous Skin Fillers

Nassar¹,

Dorizas²,

Sadick³

2022

Cosmetic Dermatology

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The effect of autologous activated platelet‐rich plasma injection on female pattern hair loss: A randomized placebo‐controlled study

Abstract: Platelet-rich plasma injections can be regarded as an alternative for the treatment of female pattern hair loss with minimal morbidity and a low cost-to-benefit ratio.

Cited by 73 publications

References 17 publications

Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

Autologous platelet‐rich plasma therapy for pattern hair loss: A systematic review

Autologous Skin Fillers

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