The Potential Role of Curcumin for Treatment of Pancreatic Cancer

Kanai, Masashi; Guha, Sushovan; Aggarwal, Bharat B.

doi:10.5772/27874

Cited by 28 publications

(34 citation statements)

References 48 publications

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“…Patients with PC who received 8 g curcumin by mouth daily have 22-41 ng/ml curcumin at peak in plasma (Dhillon et al, 2008). Current reports have indicated that 2-20 mM curcumin for in vitro studies, 50-200 mg/kg curcumin for mice studies, 8-12 g/day for human trial were typically utilized (Kanai, 2014;Prasad et al, 2014a,b). Due to lack of bioavailability, it is necessary to explore how to enhance the bioavailability of curcumin to reduce the dose of curcumin.…”

Section: Discussionmentioning

confidence: 95%

Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells

et al. 2014

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Section: Discussionmentioning

confidence: 95%

Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells

et al. 2014

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“…Curcumin regulates the transcription factors that are implicated to be involved in carcinogenesis by preventing their activation (Table ). Growth factors, hypoxia and cytokines have been suspected to upregulate constitutive NF‐ƙB activation in patients with cancer, and its activity is positively correlated with cancer progression (Figure ) . Curcumin prevents the activation of NF‐ƙB that can upregulate the expression of anti‐apoptotic genes, genes involved in proliferation (e.g.…”

Section: Anticancer Activity Of Curcuminmentioning

confidence: 99%

“…matrix metalloproteinases), the key plays in carcinogenesis and proliferation and inhibition of nuclear factor‐kappa B. [ ] Primary liver cancer, also called as hepatocellular carcinoma (HCC), is one of the most lethal cancers having worldwide prevalence. Curcumin suppresses liver cancer by elevating the reduced glutathione (GSH) content of the cell and downregulates the NF‐ƙB in the hepatic cells, which is actively involved in mediating abnormal cell proliferation by several mechanisms .…”

Section: Anticancer Activity Of Curcuminmentioning

confidence: 99%

“…Growth factors, hypoxia and cytokines have been suspected to upregulate constitutive NF-ƙB activation in patients with cancer, and its activity is positively correlated with cancer progression (Figure 1). [45] Curcumin prevents the activation of NF-ƙB that can upregulate the expression of antiapoptotic genes, genes involved in proliferation (e.g. cyclin D1, c-myc) and invasion (e.g.…”

Section: Antimicrobial Activity Of Curcuminmentioning

confidence: 99%

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Curcumin as potential therapeutic natural product: a nanobiotechnological perspective

Shome

Talukdar

Choudhury

et al. 2016

Journal of Pharmacy and Pharmacology

147

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Objectives Nanotechnology-based drug delivery systems can resolve the poor bioavailability issue allied with curcumin. The therapeutic potential of curcumin can be enhanced by making nanocomposite preparation of curcumin with metal oxide nanoparticles, poly lactic-co-glycolic acid (PLGA) nanoparticles and solid lipid nanoparticles that increases its bioavailability in the tissue. Key findings Curcumin has manifold therapeutic effects which include antidiabetic, antihypertensive, anticancer, anti-inflammatory and antimicrobial properties. Curcumin can inhibit diabetes, heavy metal and stress-induced hypertension with its antioxidant, chelating and inhibitory effects on the pathways that lead to hypertension. Curcumin is an anticancer agent that can prevent abnormal cell proliferation. Nanocurcumin is an improved form of curcumin with enhanced therapeutic properties due to improved delivery to the diseased tissue, better internalization and reduced systemic elimination. Summary Curcumin has multiple pharmacologic effects, but its poor bioavailability reduces its therapeutic effects. By conjugating curcumin to metal oxide nanoparticles or encapsulation in lipid nanoparticles, dendrimers, nanogels and polymeric nanoparticles, the water solubility and bioavailability of curcumin can be improved and thus increase its pharmacological effectiveness.

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“…Further studies are planned to investigate the effects of intravenous administration of CMG on other types of cancer, as several reports have indicated that curcumin has an antitumor effect on various tumors including refractory pancreatic cancer, [45][46][47] and lung cancer. [48][49][50] In addition, further investigation on tumor suppressive effects by other curcumin metabolites are currently being undertaken.…”

Section: The Antitumor Effects Of Cmg Following Intravenous Injectionmentioning

confidence: 99%

Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood

Ozawa¹,

Imaizumi²,

Sumi³

et al. 2017

Biological & Pharmaceutical Bulletin

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Curcumin, a polyphenol derived from the rhizome of the naturally occurring plant Curcuma longa, has various pharmacological actions such as antioxidant and anti-inflammatory effects. In this paper, we evaluated the role of its internal metabolite, curcumin β-D-glucuronide (curcumin monoglucuronide, CMG), by investigating curcumin kinetics and metabolism in the blood. Firstly, we orally administered highly bioavailable curcumin to rats to elucidate its kinetics, and observed not only the free-form of curcumin, but also, curcumin in a conjugated form, within the portal vein. We confirmed that curcumin is conjugated when it passes through the intestinal wall. CMG, one of the metabolites, was then orally administered to rats. Despite its high aqueous solubility compared to free-form curcumin, it was not well absorbed. In addition, CMG was injected intravenously into rats in order to assess its metabolic behavior in the blood. Interestingly, high levels of free-form curcumin, thought to be sufficiently high to be pharmacologically active, were observed. The in vivo antitumor effects of CMG following intravenous injection were then evaluated in tumor-bearing mice with the HCT116 human colon cancer cell line. The tumor volume within the CMG group was significantly less than that of the control group. Moreover, there was no significant loss of body weight in the CMG group compared to the control group. These results suggest that CMG could be used as an anticancer agent without the serious side effects that most anticancer agents have.

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The Potential Role of Curcumin for Treatment of Pancreatic Cancer

Cited by 28 publications

References 48 publications

Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells

Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells

Curcumin as potential therapeutic natural product: a nanobiotechnological perspective

Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood

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