The potential regulatory role of BMP9 in inflammatory responses

Song, Tianzhu; Huang, Dingming; Song, Dongzhe

doi:10.1016/j.gendis.2021.08.010

Cited by 5 publications

(2 citation statements)

References 129 publications

(148 reference statements)

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“…[ 46 ] Different from other BMPs, BMP9 is distinguished because of its potent activity, most likely attributable to the fact that it cannot be inhibited by extracellular antagonists, such as Noggin and BMP3. [ 47 ] Notably, BMP3 can suppress osteogenic differentiation and negatively regulates bone density by modulating TGF‐β receptor availability to other ligands. [ 48 ] According to bioinformatic analyses of global transcriptomic changes by RNA‐seq of human gingival tissues, BMP2, BMP7, and BMP receptors (like BMPR1A and BMPR2) are significantly decreased for the diseased patients relative to the healthy ones, while BMP3 is significantly increased (Figure S12, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Pathogenesis‐Guided Engineering of Multi‐Bioactive Hydrogel Co‐Delivering Inflammation‐Resolving Nanotherapy and Pro‐Osteogenic Protein for Bone Regeneration

Liu

Wang

et al. 2023

Adv Funct Materials

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There are still great challenges in promoting bone defect repair via regeneration strategies. In view of delayed bone healing due to local inflammation, herein, pathogenesis‐guided engineering of multi‐bioactive hydrogel therapy is proposed for bone regeneration, by simultaneously improving the osteoimmune environment and enhancing osteogenic differentiation of stem cells. After discovering the pivotal role of persistent inflammation and bone loss in the pathogenesis of periodontitis by transcriptomics, a multi‐bioactive nanotherapy based on self‐assembled nanomicelles (PP5 NMs) is first developed. PP5 NMs effectively rescue osteogenesis of human periodontal ligament cells under pathological conditions and promote bone formation in rats with mandibular or cranial bone defects. By integrating PP5 NMs, a pro‐osteogenic protein rhBMP9, and a hydrogel‐forming temperature‐responsive material, a multifunctional hydrogel therapy is further engineered, which can regulate the pro‐inflammatory/oxidative microenvironment and accelerate bone regeneration. The obtained multi‐bioactive hydrogel capable of co‐delivering and sustainedly releasing PP5 NMs and rhBMP9 displays excellent bone regeneration capability, by synergistic effects of inflammation‐resolving and pro‐osteogenic differentiation of stem cells. Mechanistically, this hydrogel therapy improves the osteoimmune environment by attenuating pathogenesis and enhancing stem cell differentiation via the TLR4/NF‐κB/HO‐1 axis and activating the Smad1/5/8 protein complex. The hydrogel is promising for treating different inflammatory bone diseases.

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Section: Resultsmentioning

confidence: 99%

Pathogenesis‐Guided Engineering of Multi‐Bioactive Hydrogel Co‐Delivering Inflammation‐Resolving Nanotherapy and Pro‐Osteogenic Protein for Bone Regeneration

Liu

Wang

et al. 2023

Adv Funct Materials

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“…Even though the precise distribution varies slightly between species ( 53 ), in general, bone morphogenetic protein 9 (BMP9) is considered to be mainly expressed in the liver of adult individuals as a circulating factor produced by hepatic stellate cells ( 54 ). In managing liver sinusoidal endothelial cells fenestration and guarding against perivascular hepatic fibrosis, it is a crucial paracrine regulator of liver homeostasis ( 55 , 56 ).…”

Section: Hepatokines: From Liver To Bonementioning

confidence: 99%

The roles of hepatokine and osteokine in liver-bone crosstalk: Advance in basic and clinical aspects

et al. 2023

Front. Endocrinol.

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Both the liver and bone are important secretory organs in the endocrine system. By secreting organ factors (hepatokines), the liver regulates the activity of other organs. Similarly, bone-derived factors, osteokines, are created during bone metabolism and act in an endocrine manner. Generally, the dysregulation of hepatokines is frequently accompanied by changes in bone mass, and osteokines can also disrupt liver metabolism. The crosstalk between the liver and bone, particularly the function and mechanism of hepatokines and osteokines, has increasingly gained notoriety as a topic of interest in recent years. Here, based on preclinical and clinical evidence, we summarize the potential roles of hepatokines and osteokines in liver-bone interaction, discuss the current shortcomings and contradictions, and make recommendations for future research.

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The importance of BMPs and TGF-βs for endochondral bone repair – A longitudinal study in hip arthroplasty patients

Cassuto,

Folestad,

Göthlin

et al. 2023

Bone Reports

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The potential regulatory role of BMP9 in inflammatory responses

Cited by 5 publications

References 129 publications

Pathogenesis‐Guided Engineering of Multi‐Bioactive Hydrogel Co‐Delivering Inflammation‐Resolving Nanotherapy and Pro‐Osteogenic Protein for Bone Regeneration

Pathogenesis‐Guided Engineering of Multi‐Bioactive Hydrogel Co‐Delivering Inflammation‐Resolving Nanotherapy and Pro‐Osteogenic Protein for Bone Regeneration

The roles of hepatokine and osteokine in liver-bone crosstalk: Advance in basic and clinical aspects

The importance of BMPs and TGF-βs for endochondral bone repair – A longitudinal study in hip arthroplasty patients

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