The potential palliative role and possible immune modulatory effects of low-dose total body irradiation in relapsed or chemo-resistant non-Hodgkin's lymphoma

Safwat, Akmal; Bayoumy, Yasser; El-Sharkawy, Nahla; Shaaban, Khaled; Mansour, O.; Kamel, Azza M.

doi:10.1016/s0167-8140(03)00247-0

Cited by 21 publications

(25 citation statements)

References 13 publications

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“…Specifically, LDI treatment has been shown to stimulate the cancer patients' immune system to attack and kill cancer cells (Jerry and Myron 2003;Liu 2003). This therapy has been used to treat many types (Cuttler et al 2000;Safwat 2000;Safwat et al 2003;Sakamoto et al 1997). While the majority of these studies have been performed using X-ray or γ-ray irradiation (Cuttler et al 2000;Safwat 2000), very few studies have employed high linear energy transfer (LET) radiation.…”

Section: Introductionmentioning

confidence: 99%

Early Effects of Low Dose¹²C⁶⁺Ion or X-Ray Irradiation on Peripheral Blood Lymphocytes of Patients with Alimentary Tract Cancer

Chen

et al. 2010

Dose-Response

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ᮀ The aim of this study was to examine the early effects of low dose 12 C 6+ irradiation or X-ray on peripheral blood lymphocytes (PBL) of patients with alimentary tract cancer and to explore mechanisms that may be involved in an antitumor immune response. We found that the percentage of T lymphocyte subsets, the mRNA expression levels of IL-2 and IFN-γ in PBL, and their protein levels in supernatant were significantly increased 24 hours after exposure to low dose radiation. The effects were more pronounced in the group receiving 0.05Gy 12 C 6+ ion irradiation than the group receiving X-ray irradiation. There was no significant change in the percentage of NK cell subsets and TNF-α production of PBL. Our study suggests that low dose irradiation could alleviate immune suppression caused by tumor burden and that the effect was more pronounced for 0.05Gy high linear energy transfer (LET) 12 C 6+ irradiation.

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Section: Introductionmentioning

confidence: 99%

Early Effects of Low Dose¹²C⁶⁺Ion or X-Ray Irradiation on Peripheral Blood Lymphocytes of Patients with Alimentary Tract Cancer

Chen

et al. 2010

Dose-Response

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“…Absorption of low doses of ionizing radiation may stimulate cellular detoxification and repair mechanisms leading to reduction of the DNA damage even below the spontaneous level and decreasing the probability of neoplastic transformation (for review see: Azzam et al 1996, Pollycove 2004, Mitchel 2007, Portess et al 2007, Redpath and Elmore 2007, Feinendegen et al 2008. Such exposures may also enhance immune reactions of the organism and attenuate harmful effects of higher doses of radiation (Liu et al 1982, 1985, Tuschl et al 1995, Safwat 2000b, Safwat et al 2003; for review see : Liu 1989, Luckey 1980, Ju et al 1995. These mechanisms may explain various epidemiological observations indicating that cancer incidence and mortality are not elevated among inhabitants of the high-versus low-background radiation areas (Ishii et al 1996, Kesavan 1997, Jagger 1998; for review see: Luckey 1999, Wei andSugahara 2000) as well as among tenants of homes with the elevated levels of radiation from 222 Rn or 60 Co (Cohen 1995, UNSCEAR 2000, Wang et al 2002, Chen et al 2004.…”

Section: Introductionmentioning

confidence: 99%

Immunological Mechanism of the Low-Dose Radiation-Induced Suppression of Cancer Metastases in a Mouse Model

Nowosielska¹,

Cheda²,

Wrembel-Wargocka³

et al. 2009

Dose-Response

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ᮀ According to the doctrine underlying the current radiation protection regulations each, no matter how small, exposure to ionizing radiation may be carcinogenic. However, numerous epidemiological observations demonstrate that cancer incidence and/or mortality are not elevated among inhabitants of the high-versus low-natural-background radiation areas and homes. Results of our own and other authors' studies described in this paper bear testimony to the possibility that stimulation of the anti-neoplastic immune surveillance mediated by NK lymphocytes and activated macrophages explains, at least partially, the accumulating epidemiological and experimental evidence indicating that lowlevel exposures to the low-linear energy transfer (LET) radiation inhibit the development of spontaneous and artificial metastases in humans and laboratory animals, respectively. The results presented also suggest the possibility of using low-level X-and gamma-ray exposures to cure cancer and to prevent cancer metastases. For a broader perspective, the results presented may help towards relaxing the current radiation protection regulations, especially as they apply to diagnostic and therapeutic exposures of patients to the indicated forms of radiation.

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“…Such low dose exposures may also enhance immune reactions of the organism and attenuate harmful effects of higher doses of radiation (Safwat, 2000 andSafwat et al, 2003). These mechanisms may explain that nuclear workers and in the survivors of the Hiroshima and Nagasaki bombings whose absorbed doses did not exceed 0.25Gy, were reported to have low incidence of leukaemia and some solid tumours when compared to the respective control groups (Katayama et al, 2002 andMatanoski et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

“…Cellular detoxification, DNA reduction, decreasing the probability of neoplastic transformation, tumour growth delay, antimetastatic effects and sensitization of tumour could be achieved via exposure to low doses of ionizing radiation (Hosoi, 2006 andRedpath andElmore, 2007). Such exposures may also enhance immune reactions and attenuate harmful effects of higher doses of radiation (Safwat, 2000 andSafwat et al, 2003). These may explain the low incidence of leukaemia and some solid tumours as reported among nuclear workers and in the survivors of the Hiroshima and Nagasaki bombings whose absorbed doses did not exceed 0.25 Gy (Katayama et al, 2002 andMatanoski, et al, 1990).…”

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confidence: 99%

Antiproliferative Effect of Lactobacillus helveticus and Low Dose Gamma Radiation on Mammary Carcinogenesis

2013

Egypt. J. Rad.Sci.

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MMUNOTHERAPY plays an important role in cancer prevention and treatment. This study was aimed to investigate the role of milk fermented by Lactobacillus helveticus (L. helveticus) and low dose of gamma radiation (0.25 Gy) as protector and immunotherapy for breast cancer.Female rats were divided into 7 groups, control group, fermented milk with L. helveticus (FM) Group, whole body gamma irradiated group, injected with 17β-estradiol (E2) group, FM and injected with E2 group, gamma irradiation and E2 group and FM then exposed to gamma radiation and injected with E2.Results showed that, E2 caused a reduction in the percentage of cluster of differentiation 4 (CD4) and cluster of differentiation 8 (CD8), an decrease in glutathione (GSH), malonaldehyde (MDA), nitric oxide (NO) levels and glutathione peroxidase (GPx), but increase in catalase (CAT) and superoxide dismutase (SOD) activities as well as an increase in the proliferation marker Ki-67 (Antigen KI-67 also known as Ki-67), with hyperplasia appeared in the histological examinations of mammary tissue epithelium. FM with or without gamma radiation increased CD4 and CD8 count, ameliorated GSH, MDA and NO levels, GPx, CAT and SOD activities and reduced Ki-67 percentage. Histological study showed normal breast tissue. This study demonstrated that FM and gamma radiation (0.25 Gy) induced immunoregulatory and antioxidant capacity in preventing carcinogenic effect of E2 on breast tissue.

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The potential palliative role and possible immune modulatory effects of low-dose total body irradiation in relapsed or chemo-resistant non-Hodgkin's lymphoma

Cited by 21 publications

References 13 publications

Early Effects of Low Dose¹²C⁶⁺Ion or X-Ray Irradiation on Peripheral Blood Lymphocytes of Patients with Alimentary Tract Cancer

Early Effects of Low Dose¹²C⁶⁺Ion or X-Ray Irradiation on Peripheral Blood Lymphocytes of Patients with Alimentary Tract Cancer

Immunological Mechanism of the Low-Dose Radiation-Induced Suppression of Cancer Metastases in a Mouse Model

Antiproliferative Effect of Lactobacillus helveticus and Low Dose Gamma Radiation on Mammary Carcinogenesis

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The potential palliative role and possible immune modulatory effects of low-dose total body irradiation in relapsed or chemo-resistant non-Hodgkin's lymphoma

Cited by 21 publications

References 13 publications

Early Effects of Low Dose12C6+Ion or X-Ray Irradiation on Peripheral Blood Lymphocytes of Patients with Alimentary Tract Cancer

Early Effects of Low Dose12C6+Ion or X-Ray Irradiation on Peripheral Blood Lymphocytes of Patients with Alimentary Tract Cancer

Immunological Mechanism of the Low-Dose Radiation-Induced Suppression of Cancer Metastases in a Mouse Model

Antiproliferative Effect of Lactobacillus helveticus and Low Dose Gamma Radiation on Mammary Carcinogenesis

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Product

Resources

About

Early Effects of Low Dose¹²C⁶⁺Ion or X-Ray Irradiation on Peripheral Blood Lymphocytes of Patients with Alimentary Tract Cancer

Early Effects of Low Dose¹²C⁶⁺Ion or X-Ray Irradiation on Peripheral Blood Lymphocytes of Patients with Alimentary Tract Cancer