2003
DOI: 10.1016/s0167-8140(03)00247-0
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The potential palliative role and possible immune modulatory effects of low-dose total body irradiation in relapsed or chemo-resistant non-Hodgkin's lymphoma

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Cited by 21 publications
(25 citation statements)
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“…Specifically, LDI treatment has been shown to stimulate the cancer patients' immune system to attack and kill cancer cells (Jerry and Myron 2003;Liu 2003). This therapy has been used to treat many types (Cuttler et al 2000;Safwat 2000;Safwat et al 2003;Sakamoto et al 1997). While the majority of these studies have been performed using X-ray or γ-ray irradiation (Cuttler et al 2000;Safwat 2000), very few studies have employed high linear energy transfer (LET) radiation.…”
Section: Introductionmentioning
confidence: 99%
“…Specifically, LDI treatment has been shown to stimulate the cancer patients' immune system to attack and kill cancer cells (Jerry and Myron 2003;Liu 2003). This therapy has been used to treat many types (Cuttler et al 2000;Safwat 2000;Safwat et al 2003;Sakamoto et al 1997). While the majority of these studies have been performed using X-ray or γ-ray irradiation (Cuttler et al 2000;Safwat 2000), very few studies have employed high linear energy transfer (LET) radiation.…”
Section: Introductionmentioning
confidence: 99%
“…Absorption of low doses of ionizing radiation may stimulate cellular detoxification and repair mechanisms leading to reduction of the DNA damage even below the spontaneous level and decreasing the probability of neoplastic transformation (for review see: Azzam et al 1996, Pollycove 2004, Mitchel 2007, Portess et al 2007, Redpath and Elmore 2007, Feinendegen et al 2008. Such exposures may also enhance immune reactions of the organism and attenuate harmful effects of higher doses of radiation (Liu et al 1982, 1985, Tuschl et al 1995, Safwat 2000b, Safwat et al 2003; for review see : Liu 1989, Luckey 1980, Ju et al 1995. These mechanisms may explain various epidemiological observations indicating that cancer incidence and mortality are not elevated among inhabitants of the high-versus low-background radiation areas (Ishii et al 1996, Kesavan 1997, Jagger 1998; for review see: Luckey 1999, Wei andSugahara 2000) as well as among tenants of homes with the elevated levels of radiation from 222 Rn or 60 Co (Cohen 1995, UNSCEAR 2000, Wang et al 2002, Chen et al 2004.…”
Section: Introductionmentioning
confidence: 99%
“…Such low dose exposures may also enhance immune reactions of the organism and attenuate harmful effects of higher doses of radiation (Safwat, 2000 andSafwat et al, 2003). These mechanisms may explain that nuclear workers and in the survivors of the Hiroshima and Nagasaki bombings whose absorbed doses did not exceed 0.25Gy, were reported to have low incidence of leukaemia and some solid tumours when compared to the respective control groups (Katayama et al, 2002 andMatanoski et al, 1990).…”
Section: Discussionmentioning
confidence: 99%
“…Cellular detoxification, DNA reduction, decreasing the probability of neoplastic transformation, tumour growth delay, antimetastatic effects and sensitization of tumour could be achieved via exposure to low doses of ionizing radiation (Hosoi, 2006 andRedpath andElmore, 2007). Such exposures may also enhance immune reactions and attenuate harmful effects of higher doses of radiation (Safwat, 2000 andSafwat et al, 2003). These may explain the low incidence of leukaemia and some solid tumours as reported among nuclear workers and in the survivors of the Hiroshima and Nagasaki bombings whose absorbed doses did not exceed 0.25 Gy (Katayama et al, 2002 andMatanoski, et al, 1990).…”
mentioning
confidence: 99%