The potential of the genus Baccharis spp. as an insecticide for mosquitoes and non-biting flies of veterinary importance

Correa, Eduardo J.; Alves, Stênio Nunes; Coimbra, Mairon César; Lima, Leonardo Henrique França de

doi:10.1016/b978-0-323-85579-2.00012-5

Cited by 3 publications

(2 citation statements)

References 66 publications

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“…Baccharis is a dioecious, neotropical genus and the most diverse in the Asteraceae family [9][10][11]. It has between 354 to 500 species of shrubs, perennial herbaceous, subshrubs, aromatic, and native to the American continent [12][13][14]. The regions of the genus with the highest taxonomic richness are the tropical Andes and southeastern Brazil [15].…”

Section: Introductionmentioning

confidence: 99%

Polyphenols and Flavonoids Composition, Anti-Inflammatory and Antioxidant Properties of Andean Baccharis macrantha Extracts

Rosero

Pozo

Simbaña

et al. 2022

Plants

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This study examined the leaves of Baccharis macrantha to obtain extracts of Baccharis macrantha (EBM) and to determine the total flavonoid content (TFC) and the total polyphenol content (TPC). The main objective of this work was to quantify TPC and TFC of extracts of B. macrantha from Ecuador and evaluate its antioxidant and anti-inflammatory activities and inhibition of lipid peroxidation. The extraction method was optimized with solvents, ethanol, and methanol, at temperatures of 30–60 °C and extraction times of 5–20 min. The optimal TFC extraction conditions were at EtOH25% at 50 °C for 10 min. The optimal TPC extraction conditions were at EtOH50% at 50 °C for 10 min. EBM was characterized by TLC and HPLC with three standards: gallic acid, catechin, and quercetin. EBM-EtOH25% and EBM-EtOH50% obtained at 50 °C for 10 min were used to identify quercetin and evaluate biologicals activities. Quercetin was detected in EBM (EtOH25% and EtOH50%). EBM anti-inflammatory activity was evaluated with the red blood cell stabilization (RBC) method. The RBC model showed values of 49.72% of protection lysis RBC to EBM-EtOH25% and 50.71% of protection lysis RBC to EBM-EtOH50%. The EBM in vitro inhibition of lipid peroxidation showed a protection of 77.00% (EtOH25%) and 73.11% (EtOH50%) when the TBARs method was used. EBM-EtOH25% and EtOH50% showed high antioxidant activity. EBM-EtOH25% presented values of ABTS (1172 µmol TE/g EBM), DPPH (836 µmol TE/g, EBM), and FRAP (85.70 µmol TE/g, EBM).

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Section: Introductionmentioning

confidence: 99%

Polyphenols and Flavonoids Composition, Anti-Inflammatory and Antioxidant Properties of Andean Baccharis macrantha Extracts

Rosero

Pozo

Simbaña

et al. 2022

Plants

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“…Inside the synaptic cleft, this enzyme breaks acetylcholine into choline and acetyl, interrupting the nervous system's electric impulses [13]. Its inhibition causes acetylcholine accumulation resulting in fatal nervous system overstimulation, and consequently, this is widely targeted for common insecticides [14,4]. The ionotropic γ-aminobutyric acid receptors (GABAaR) act in insect neurotransmission in both central and peripheral neural systems (Figs.…”

Section: Introductionmentioning

confidence: 99%

Virtual screening and cheminformatics descriptors uncover insecticidal molecular mechanisms besides plant essential oils' action.

Correa

Carvalho

Oliveira

et al. 2022

Preprint

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Plant essential oils (EOs) are important for discovering new bioactive substances, such as environmentally safe insecticides. However, the high structural diversity of EOs compounds and their elusive biochemical mechanisms make a gap in knowledge of their major targets and action mechanisms. Here we present a predictive cheminformatics methodology and experimental validation of the ability of EO's typical natural compounds to act as potential insecticides against canonical insect molecular targets. A cheminformatics analysis protocol was created to identify chemical signatures of compounds present in EOs capable of interfering with typical targets of insecticides. Three of our clusters presented strong respective signatures for JH-like, Steroids-like and biogenic-amines-like structures, all of them with reported anti-insecticidal effects. Case studies highlight the participation of juvenile hormone-specific proteins (JHBP and MET) and the octopamine receptor at agonist conformation (OctpR ago) as major targets for EOs of typical Brazilian plants. In vivo application of leave’s EOs from Baccharis dracunculifolia on blowflies led to dose-response symptoms in adults, larvae and hatching consonants with such signatures. Taking it all together, the present study points out the success of a promising methodology to identify insecticidal pharmacophore signatures on plants' EOs, which can be of high value for the bioprospection of new natural products and molecules with agro and health interests.

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Spatial repellency effects of Taiwanese plant oils on the biting midge, Forcipomyia taiwana

et al. 2023

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The potential of the genus Baccharis spp. as an insecticide for mosquitoes and non-biting flies of veterinary importance

Cited by 3 publications

References 66 publications

Polyphenols and Flavonoids Composition, Anti-Inflammatory and Antioxidant Properties of Andean Baccharis macrantha Extracts

Polyphenols and Flavonoids Composition, Anti-Inflammatory and Antioxidant Properties of Andean Baccharis macrantha Extracts

Virtual screening and cheminformatics descriptors uncover insecticidal molecular mechanisms besides plant essential oils' action.

Spatial repellency effects of Taiwanese plant oils on the biting midge, Forcipomyia taiwana

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