The potential of salivary biomarkers of nutritional status and dietary intake: A Systematic Review

Logan, Danielle; Wallace, Sue; Woodside, Jayne V.; McKenna, Gerald

doi:10.1016/j.jdent.2021.103840

Cited by 6 publications

(1 citation statement)

References 90 publications

(118 reference statements)

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“…From the studies considered herein, evidence would suggest that saliva could represent a viable bio-matrix to allow determination of iodine status. This offers an alternative means for the assessment of iodine nutrition status that is non-invasive and rapid and can be collected by people with little clinical experience (43) . Additionally, the consistency in salivary iodide secretion within individuals across multiple days lends further credence to its validity.…”

Section: Discussionmentioning

confidence: 99%

Salivary iodide status as a measure of whole body iodine homoeostasis?

Alsaeedi,

Rose,

Welham

2024

Br J Nutr

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Iodine is a trace element required to produce the thyroid hormones, which are critical for development, growth and metabolism. To ensure appropriate population iodine nutrition, convenient and accurate methods of monitoring are necessary. Current methods for determining iodine status either involve a significant participant burden or are subject to considerable intra-individual variation. The continuous secretion of iodide in saliva potentially permits its use as a convenient, non-invasive assessment of status in populations. To assess its likely effectiveness, we reviewed studies analysing the association between salivary iodide concentration (SIC) and dietary iodine intake, urinary iodide concentration (UIC) and/or 24-h urinary iodide excretion (UIE). Eight studies conducted in different countries met the inclusion criteria, including data for 921 subjects: 702 healthy participants and 219 with health conditions. SIC correlated positively with UIC and/or UIE in four studies, with the strength of relationship ranging from r=0.19 to r=0.90 depending on sampling protocol, age, and if salivary values were corrected for protein concentration. Additionally, SIC positively correlated with dietary intake, being strongest when saliva was collected after dinner. SIC varied with external factors, including thyroid function, use of some medications, smoking, and overall health status. Evidence provided here supports the use of SIC as a viable, low-burden method for determining iodine status in populations. However small sample sizes and high variability indicates the need for more extensive analyses across age groups, ethnicities, disease states and dietary groups to clarify the relative accuracy and reliability in each case and standardise procedure.

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Section: Discussionmentioning

confidence: 99%