The potential of probiotics in the amelioration of hyperuricemia

Zhao, Hongyuan; Lu, Zhaoxin; Lu, Yingjian

doi:10.1039/d1fo03206b

Cited by 52 publications

(36 citation statements)

References 190 publications

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“…Particularly, L. paracasei X11 treatment increased the abundance of some beneficial gut microbes, such as Faecalibaculum , which was reported to produce SCFAs to ameliorate tumor progression ( 28 ). More importantly, it was reported that there was a strong correlation between the gut microbiota and inflammatory cytokines of the immune-inflammatory pathways ( 35 ), which was consistent with the phenomena observed in our study. These results could be inferred that L. paracasei X11 might regulate intestinal immune homeostasis via the gut microbiota in HUA mice.…”

Section: Discussionsupporting

confidence: 93%

“…The diversity and the abundance of gut microbiota in the MOD group were largely lessened compared to those of the CON group, which were moderated and improved by L. paracasei X11 administration. Furthermore, the α-diversity and β-diversity of microbiota could be used to predict the activation of cells and dynamic balance of gut flora ( 35 ), which became a normal microbial community in the X11 group. At the phylum level, L. paracasei X11 alleviated the relative abundance of Bacteroidetes and Proteobacteria and adjusted the proportion of Bacteroidetes to Firmicutes to the normal level.…”

Section: Discussionmentioning

confidence: 99%

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Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice

et al. 2022

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Hyperuricemia (HUA) is the presence of excessive uric acid (UA) in blood, which leads to an increased risk of chronic kidney disease and gout. Probiotics have the potential effect of alleviating HUA. The purpose of this study was to screen probiotics with UA-lowering activity and explore the underlying mechanism. The UA-lowering activity of 20 lactic acid bacteria strains was investigated in vitro, and the effect of candidate probiotics on UA metabolism was evaluated using the HUA Balb/c mouse model. The results showed that Lactobacillus paracasei X11 had excellent UA-lowering activity in vitro, which could degrade nucleotides and nucleosides completely within 30 min, and the degradation rates of purine and trioxypurine could reach 83.25% and 80.42%, respectively. In addition, oral administration of L. paracasei X11 could reduce serum UA by 52.45% and inhibit renal proinflammatory cytokine IL-1β by 50.69%, regulating adenosine deaminase (ADA), xanthine oxidase (XOD), and transporter expression (GLUT9, NPT1, and URAT1) to a normal level. Moreover, it could restore the ratio of Bacteroidetes to Firmicutes (Bac/Firm ratio) and showed a positive effect on the recovery of the intestinal microbiota. These findings provided fundamental information about the UA-lowering properties of probiotics, which suggested that L. paracasei X11 had the potential to be developed as a novel probiotic strain to ameliorate HUA.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice

et al. 2022

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“…Current studies have found that gut microbiota imbalances exist in patients with HUA and gout ( Chu et al., 2021 ; Yin et al., 2022 ). In addition, the gut microbiota can be altered after UA reduction ( Yu et al., 2018 ), and probiotics may have UA-lowering effects ( Wu et al., 2021 ; Zhao and Lu, 2022 ). Therefore, an in-depth study of the relationship between gut microbes and HUA and gout is expected to make it a target for the prevention and treatment of related diseases.…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout

Wang

Liao

et al. 2022

Front. Cell. Infect. Microbiol.

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The incidence of hyperuricemia (HUA) and gout continuously increases and has become a major public health problem. The gut microbiota, which colonizes the human intestine, has a mutually beneficial and symbiotic relationship with the host and plays a vital role in the host’s metabolism and immune regulation. Structural changes or imbalance in the gut microbiota could cause metabolic disorders and participate in the synthesis of purine-metabolizing enzymes and the release of inflammatory cytokines, which is closely related to the occurrence and development of the metabolic immune disease HUA and gout. The gut microbiota as an entry point to explore the pathogenesis of HUA and gout has become a new research hotspot. This review summarizes the characteristics of the gut microbiota in patients with HUA and gout. Meanwhile, the influence of different dietary structures on the gut microbiota, the effect of the gut microbiota on purine and uric acid metabolism, and the internal relationship between the gut microbiota and metabolic endotoxemia/inflammatory factors are explored. Moreover, the intervention effects of probiotics, prebiotics, and fecal microbial transplantation on HUA and gout are also systematically reviewed to provide a gut flora solution for the prevention and treatment of related diseases.

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“…Hyperuricemia can cause gout and other metabolic disorders, it often occurs as a result of metabolic problems or an excessive intake of purine-rich foods ( Zhao et al., 2022 ). Probiotics have been demonstrated the potential to ameliorate hyperuricemia in animals.…”

Section: Discussionmentioning

confidence: 99%

Probiotic Limosilactobacillus fermentum GR-3 ameliorates human hyperuricemia via degrading and promoting excretion of uric acid

Zhao¹,

Feng²,

Hu³

et al. 2022

iScience

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The potential of probiotics in the amelioration of hyperuricemia

Abstract: Hyperuricemia is a common disease caused by metabolic disorders or excessive intake of high-purine foods. Persistent hyperuricemia in extreme cases induces gout, and asymptomatic hyperuricemia is probably linked to...

Cited by 52 publications

References 190 publications

Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice

Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice

Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout

Probiotic Limosilactobacillus fermentum GR-3 ameliorates human hyperuricemia via degrading and promoting excretion of uric acid

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