The potential of phototherapy to reduce body fat, insulin resistance and “metabolic inflexibility” related to obesity in women undergoing weight loss treatment

Sene-Fiorese, Marcela; Duarte, Fernanda Oliveira; Aquino, Antônio Eduardo de; Campos, Raquel Munhoz da Silveira; Masquio, Deborah Cristina Landi; Tock, Lian; Duarte, Ana Cláudia Garcia de Oliveira; Dâmaso, Ana Raimunda; Parizotto, Nivaldo Antônio; Bagnato, Vanderlei Salvador

doi:10.1002/lsm.22395

Cited by 32 publications

(36 citation statements)

References 58 publications

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“…Thus, it is possible to observe that the combination of moderate intensity exercises, nutritional education and low level laser therapy, was more efficient, as confirmed by previous studies [21][22][23][24][25]37,39]. These reductions may lead to the decrease in the likelihood of comorbidities, such as hypertension [8,40], various cardiovascular problems [3,40] insulin resistance and diabetes mellitus type 2 [3,41].…”

Section: Discussionsupporting

confidence: 62%

“…This process demonstrates the action of using low level laser associated with moderate intensity exercise to promote enzymatic modulations [19,35] and mitochondrial alterations [19,36] that potentiate the beneficial effect of physical exercise [18][19][20][21][22][23]37,38].…”

Section: Discussionmentioning

confidence: 87%

“…In the Laboratory of Technological Support (LAT) of the São Carlos Institute of Physics, University of Sao Paulo (IFSC-USP), specifically for this research, four plates (20 × 20 cm each) made of rubberized material [21][22][23] were used for phototherapy. Each plate containing 16 diode lasers arranged in 4 lines distant 2.5 cm from each other, and each laser emitting in continuous mode, with 100 mW of output power through a 0.0169 cm 2 elliptical spot.…”

Section: Phototherapy Intervention (Phototherapy Group)mentioning

confidence: 99%

“…The respective heights were obtained by stadiometer. After obtaining these primary data, a bioelectrical impedance analysis was carried out by means of a body composition analyzer (In Body model 720, Biospace Co. Ltd.; Seoul, Korea), using 6 different frequencies (1, 5, 50, 250, 500 and 1000 kHz), to evaluate the evolution of the volunteers during the treatment [22]. Thus, the following parameters were evaluated: body mass (kg); total body fat (kg); total trunk fat (kg), visceral fat (cm 2 ); total skeletal muscle mass (kg), and basal metabolic rate (BMR) (kcal).…”

Section: Analysis Of Body Compositionmentioning

confidence: 99%

“…Recently in experimental [18][19][20] and clinical [21][22][23][24][25] studies of our group, it was established the conjugated use of physical exercise, nutritional education and phototherapy (with infrared lasers or LEDs). Thus, it Journal of Obesity & Weight Loss Therapy was observed that, both experimental and clinical character, the administration of physical exercise, nutritional education and phototherapy protocols, besides reducing the anthropometric parameters (body weight, fat depots, circumferences and skeletal muscle mass), marked improvement of the lipid profile, reversing dyslipidemia, reducing insulin values, insulin resistance, besides enabling hepatic alterations, found in experimental studies [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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Regression of Non-Alcoholic Fatty Liver by Metabolic Reduction: Phototherapy in Association with Aerobic Plus Resistance Training In Obese Man - A Pilot Study

Aquino¹,

Carbinatto²,

Moriyama³

et al. 2017

J Obes Weight Loss Ther

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The excessive body fat, one of the results of obesity, brings with it comorbidities such as lipid changes, insulin resistance, diabetes mellitus type 2 and non-alcoholic fatty liver disease. In this controlled and randomized pilot study, as a non-pharmacological and non-invasive strategy, we consider two groups during 8 weeks: the use of moderate intensity physical exercise and nutritional education, as control group (n=10) and moderate intensity physical exercise, nutritional education and phototherapy (n=10), as phototherapy group. The used phototherapy parameters were: laser Ga-Al-As, wavelength 808 nm, continuous mode, output power 100 mW, and total energy delivery 92.16 J. Selected patients were men with age between 20 and 40 years old, primary obesity, body mass index (BMI) between 30 and 34.9 kg/m 2 . The special device as described in the text was applied, allocated in the anterior region and posterior region of body during 5 minutes each side, totalizing 10 minutes of application of light, always at the end after session of exercise. Comparing the control group in relation to the phototherapy group, the better results were obtained for the phototherapy group, with statistical difference in all anthropometric variables, such as the increase of 3.54% (p<0.007) in total skeletal muscle mass; as well as, 2.77% (p<0.005) in the basal metabolic rate body; 5.47% (p<0.04) for metabolic progress; reduction of 4.67% (p<0.007) for body mass and reduction was also observed for total body fat, total trunk fat and visceral fat of which the phototherapy group showed the following reduction percentages: 14.3% (p<0.01), 14.7% (p<0.005) and 16.4% (p<0.03), respectively. A significant improvement was also observed in all the biochemical parameters and enzymatic analyzed, such as total cholesterol, triglyceride, the basal insulin, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and gamma-glutamyl-transpeptidase. Therefore the proposed treatment in this work suggests that the association of physical exercise, the nutritional education and phototherapy applied in obese men for two months caused great improvement in all anthropometric parameters, as well as, in all biochemistry and enzymatic parameters indicating that phototherapy is a potential instrument in the treatment of non-alcoholic fatty liver disease, being able to reverse the degree of steatosis in 8 weeks, besides it can be a new non-invasive treatment to obesity and its comorbidities.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 87%

Section: Phototherapy Intervention (Phototherapy Group)mentioning

confidence: 99%

Section: Analysis Of Body Compositionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regression of Non-Alcoholic Fatty Liver by Metabolic Reduction: Phototherapy in Association with Aerobic Plus Resistance Training In Obese Man - A Pilot Study

Aquino¹,

Carbinatto²,

Moriyama³

et al. 2017

J Obes Weight Loss Ther

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Insulin resistance is improved in high‐fat fed mice by photobiomodulation therapy at 630 nm

Silva

Ferraresi

Almeida

et al. 2020

Journal of Biophotonics

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Photobiomodulation therapy (PBMT) in the infrared spectrum exerts positive effects on glucose metabolism, but the use of PBMT at the red spectrum has not been assessed. Male Swiss albino mice were divided into low‐fat control and high‐fat diet (HFD) for 12 weeks and were treated with red (630 nm) PBMT or no treatment (Sham) during weeks 9 to 12. PBMT was delivered at 31.19 J/cm2, 60 J total dose per day for 20 days. In HFD‐fed mice, PBMT improved glucose tolerance, insulin resistance and fasting hyperinsulinemia. PBMT also reduced adiposity and inflammatory infiltrate in adipose tissue. Phosphorylation of Akt in epididymal adipose tissue and rectus femoralis muscle was improved by PBMT. In epididymal fat PBMT reversed the reduced phosphorylation of AS160 and the reduced Glut4 content. In addition, PBMT reversed the alterations caused by HFD in rectus femoralis muscle on proteins involved in mitochondrial dynamics and β‐oxidation. In conclusion, PBMT at red spectrum improved insulin resistance and glucose metabolism in HFD‐fed mice.

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Dose and time–response effect of photobiomodulation therapy on glycemic control in type 2 diabetic patients combined or not with hypoglycemic medicine: A randomized, crossover, double‐blind, sham‐controlled trial

Scontri,

de Castro Magalhães,

Damiani

et al. 2023

Journal of Biophotonics

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Photobiomodulation therapy (PBMt) combined or not with oral hypoglycemic medication has not been investigated in type 2 diabetes (T2DM) patients. All 10 T2DM patients were assessed randomly at 6 different occasions (3 with and 3 without regular oral hypoglycemic medication). Capillary glycemia was assessed after overnight fast (pre‐prandial), 1 h postprandially (standardized meal, 338 kcal), and 30 min, 3 h, 6 h, 12 h post‐PBMt (830 nm; 25 arrays of LEDs, 80 mW/array). Three doses (0 J—sham, 100 J, 240 J per site) were applied bilaterally on quadriceps femoris muscles, hamstrings, triceps surae, ventral upper arm and forearm; and randomly combined or not with oral hypoglicemic medication, totaling six different therapies applied for all 10 TDM2 patients (PBMt sham, PBMt 100 J, PBMt 240 J, PBMt sham + medication, PBMt 100 J + medication, PBMt 240 J + medication). Cardiac autonomic control was assessed by heart rate variability (HRV) indices. Without medication, there was reduction in glycemia after all PBMt doses, with 100 J as the best dose that persisted until 12 h and presented lower area under the curve (AUC). With medication, glycemia decreased similarly among doses. No differences between 100 J and sham + medication, but AUC was significantly lower after 100 J, suggesting better glycemic control. Low frequency component of HRV increased after sham + medication and 100 J, suggesting higher sympathetic activation. PBMt showed time– and dose–response effect to reduce glycemia in T2DM patients. Effects on HRV were consistent with glycemic control.

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The potential of phototherapy to reduce body fat, insulin resistance and “metabolic inflexibility” related to obesity in women undergoing weight loss treatment

Abstract: Our results demonstrated for the first time that phototherapy enhances the physical exercise effects in obese women undergoing weight loss treatment promoting significant changes in inflexibility metabolic profile.

Cited by 32 publications

References 58 publications

Regression of Non-Alcoholic Fatty Liver by Metabolic Reduction: Phototherapy in Association with Aerobic Plus Resistance Training In Obese Man - A Pilot Study

Regression of Non-Alcoholic Fatty Liver by Metabolic Reduction: Phototherapy in Association with Aerobic Plus Resistance Training In Obese Man - A Pilot Study

Insulin resistance is improved in high‐fat fed mice by photobiomodulation therapy at 630 nm

Dose and time–response effect of photobiomodulation therapy on glycemic control in type 2 diabetic patients combined or not with hypoglycemic medicine: A randomized, crossover, double‐blind, sham‐controlled trial

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