Insulin resistance is improved in high‐fat fed mice by photobiomodulation therapy at 630 nm

Silva, Gabriela; Ferraresi, Cleber; Almeida, Rodrigo Teixeira de; Motta, Mariana Lopes; Paixão, Thiago R.L.C.; Ottone, Vinícius O.; Fonseca, Ivana Alice Teixeira; Oliveira, Murilo Xavier; Rocha‐Vieira, Etel; Peixoto, Marco Fabrício Dias; Esteves, Elizabethe Adriana; Coimbra, Cândido Celso; Amorim, Fabiano T.; Magalhães, Flávio de Castro

doi:10.1002/jbio.201960140

Cited by 21 publications

(16 citation statements)

References 103 publications

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“…The light power was measured with a calibrated detector (Newport 918D-ST-SL wand detector from 400 to 1100 nm; Newport Corp., Irvine, CA, USA) and power meter (Newport 1936-R; Newport Corp., CA, USA). Based on previous reports of PBM regarding improved glucose intolerance [ 7 , 8 , 9 , 10 ] and the availability of LED chips for application to a catheter in our laboratory, we used an LED with wavelengths of 630 nm and 850 nm.…”

Section: Methodsmentioning

confidence: 99%

“…External photobiomodulation (PBM) with light-emitting diode (LED) in rat or mouse models may result in improved glucose tolerance, insulin resistance and fasting hyperinsulinemia, and regeneration of the pancreas and liver in previous animal models [ 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. External PBM also reduced adiposity and inflammatory infiltrate in adipose tissue [ 7 , 13 , 14 ]. This effect may be associated with increased adenosine triphosphate in mitochondria and biological response in cells by PBM [ 15 ]; however, it is not clearly proven [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Duodenal Dual-Wavelength Photobiomodulation Improves Hyperglycemia and Hepatic Parameters with Alteration of Gut Microbiome in Type 2 Diabetes Animal Model

Min

Kwon

et al. 2022

Cells

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Background: Recently, the duodenum has garnered interest for its role in treating metabolic diseases, including type 2 diabetes (T2DM). Multiple sessions of external photobiomodulation (PBM) in previous animal studies suggested it resulted in improved hyperglycemia, glucose intolerance, and insulin resistance with a multifactorial mechanism of action, despite the target organ of PBM not being clearly proven. This study aimed to determine whether a single session of a duodenal light-emitting diode (LED) PBM may impact the T2DM treatment in an animal model. Methods: Goto–Kakizaki rats as T2DM models were subjected to PBM through duodenal lumen irradiation, sham procedure, or control in 1-week pilot (630 nm, 850 nm, or 630/850 nm) and 4-week follow-up (630 nm or 630/850 nm) studies. Oral glucose tolerance tests; serum glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide, and insulin levels; liver chemistry and histology; and gut microbiome in the PBM, sham control, and control groups were evaluated. Results: In the 1-week study, duodenal dual-wavelength (D, 630/850 nm) LED PBM showed improved glucose intolerance, alkaline phosphatase and cholesterol levels, and weight gain than other groups. The D-LED PBM group in the 4-week study also showed improved hyperglycemia and liver enzyme levels, with relatively preserved pancreatic islets and increased serum insulin and GLP-1 levels. Five genera (Bacteroides, Escherichia, Parabacteroides, Allobaculum, and Faecalibaculum) were significantly enriched 1 week after the D-LED PBM. Bacteroides acidifaciens significantly increased, while Lachnospiraceae significantly decreased after 1 week. Conclusion: A single session of D-LED PBM improved hyperglycemia and hepatic parameters through the change of serum insulin, insulin resistance, insulin expression in the pancreatic β-cells, and gut microbiome in T2DM animal models.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Duodenal Dual-Wavelength Photobiomodulation Improves Hyperglycemia and Hepatic Parameters with Alteration of Gut Microbiome in Type 2 Diabetes Animal Model

Min

Kwon

et al. 2022

Cells

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“…Experimental animal research (Table 3) supports the beneficial effects of PBM applied before and after exercise in physical activity, through improved performance in endurance training [78,79], decreased level of proinflammatory cytokines [80][81][82][83][84], positive effects on aerobic metabolism [85,86], oxidative stress [86][87][88] and increased ATP [89,90]. Histopathological examination performed after PBM showed that it can protect myonecrosis, reduce pro-inflammatory cell infiltration, muscle destruction, inflammation and can help accelerate tissue repair [91][92][93].…”

Section: Discussionmentioning

confidence: 84%

Photobiomodulation and Sports: Results of a Narrative Review

Ailioaie

Litscher

2021

Life

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Benefits of photobiomodulation (PBM) have been known for several decades. More recently, PBM applied in sports offers a special chance to support the modeling of the performance and recovery. Increasingly complex physical activities and fierce competition in the world of sports generate a state of psycho-emotional and physical stress that can induce chronic fatigue syndrome, failure in physical training, predisposition to muscle damage, physical and emotional exhaustion etc., for which PBM could be an excellent solution. To evaluate and identify all risk factors and the influence of PBM on health and performance in sport and for a better understanding of its effects, we did a search for “Photobiomodulation and Sports” on PubMed, to update the PBM science applied in sports, and we retained for analysis the articles published from 2014 to date. The term “PBM” is recent, and we did not include previous studies with “low level laser therapy” or “LLLT” before 2014. In the present research, PBM has been shown to have valuable protective and ergogenic effects in 25 human studies, being the key to success for high performance and recovery, facts supported also by 22 animal studies. PBM applied creatively and targeted depending on sport and size of the level of physical effort could perfectly modulate the mitochondrial activity and thus lead to remarkable improvements in performance. PBM with no conclusive results or without effects from this review (14 studies from a total of 39 on humans) was analyzed and we found the motivations of the authors from the perspective of multiple causes related to technological limitations, participants, the protocols for physical activity, the devices, techniques and PBM parameters. In the near future, dose–response experiments on physical activity should be designed and correlated with PBM dose–response studies, so that quantification of PBM parameters to allow the energy, metabolic, immune, and neuro-endocrine modulation, perfectly coupled with the level of training. There is an urgent need to continuously improve PBM devices, delivery methods, and protocols in new ingenious future sports trials. Latest innovations and nanotechnologies applied to perform intracellular signaling analysis, while examining extracellular targets, coupled with 3D and 4D sports motion analysis and other high-tech devices, can be a challenge to learn how to maximize PBM efficiency while achieving unprecedented sports performance and thus fulfilling the dream of millions of elite athletes.

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“…In another report, Silva et al, 21 do show that insulin resistance is improved in high-fat fed mice who undergo photobiomodulation therapy at 630 nm. They concluded this after studying male Swiss albino mice divided into low-fat control and high-fat diet for 12 weeks and who were treated with red (630 nm) PBMT or no treatment (Sham) during weeks 9 to 12.…”

Section: Resultsmentioning

confidence: 92%

Photobiomodulation: a potential adjunctive obesity intervention a review

Marks¹

2021

AOWMC

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Obesity, a largely intractable health condition with incalculable health and financial and social costs and ramifications remains an immense challenge to mitigate effectively. Multiple interventions to offset obesity, while studied and implemented for many years, have generally failed to eliminate this growing global epidemic. Alternately, interventions that can offer hope, especially to those who are physically as well as emotionally challenged, with negative outcome expectations, would appear of high significance. Studied for over 40 years, various forms of light therapy are proving to be of possible adjunctive benefit in efforts to reduce excess weight. This mini review discusses some findings regarding photobiomodulation or light therapy and whether more intense study and evaluation will improve the overall obesity burden and outlook. Extracted from current literature, it is concluded that this is a field of significant promise

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Insulin resistance is improved in high‐fat fed mice by photobiomodulation therapy at 630 nm

Cited by 21 publications

References 103 publications

Duodenal Dual-Wavelength Photobiomodulation Improves Hyperglycemia and Hepatic Parameters with Alteration of Gut Microbiome in Type 2 Diabetes Animal Model

Duodenal Dual-Wavelength Photobiomodulation Improves Hyperglycemia and Hepatic Parameters with Alteration of Gut Microbiome in Type 2 Diabetes Animal Model

Photobiomodulation and Sports: Results of a Narrative Review

Photobiomodulation: a potential adjunctive obesity intervention a review

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